supported by the National Natural Science Foundation of China(82273941,81973340,82204427,81803566,82003796,81773758);Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(2017BT01Y036,China);Natural Science Foundation of Guangdong Province(2022A1515011813,2021A1515110242,2020A1515010071,2019A1515010144,2019A1515110543,2019A1515011934,China);Ministry of Science and Technology of China(2018ZX09711001-008-008);National high-level personnel of special support program(Zhang Dongmei),National Key R&D Program of China(2017YFC 1703800);Technology Key Project of Guangdong Province(2020B1111110004,China);Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research,College of Pharmacy(2020B1212060076,China);Special Funds for the Cultivation of Guangdong College Students’Scientifc and Technological Innovation(“Climbing Program”Special Funds)(pdjh2021a0052,China);Science and Technology Projects in Guangzhou(2023A03J0602,202201010173,202102070001,202002030010,China);Young S&T Talent Training Program of Guangdong Provincial Association for S&T,China(SKXRC202216);Clinical Frontier Technology Program of the First Affiliated Hospital of Jinan University(JNU1AF-CFTP-2022-a01227,China);China Postdoctoral Science Foundation(2022M 711345,China).
Lymphatic metastasis is the main metastatic route for colorectal cancer, which increases the risk of cancer recurrence and distant metastasis. The properties of the lymph node metastatic colorectal cancer(LNM-CRC) cel...
This study was supported by the National Natural Science Foundation of China(81773219);National Basic Research Program of China(2015CB553906);the Digestive Medical Coordinated Development Center of Beijing Hospitals Authority(XXT21,China);Clinical Medicine Plus X-Young Scholars Project,Peking University;the Fundamental Research Funds for the Central Universities(PKU2022LCXQ021);the PKU-Baidu Fund(2019BD015,China)。
The high incidence of lymphatic metastasis is closely related to poor prognosis and mortality in cancers.Potent inhibitors to prevent pathological lymphangiogenesis and lymphatic spread are urgently needed.The VEGF-C-...
AIM: To clarify whether perimuscular connective tissue contains more lymphatic vessels than the shallower layers in human gallbladders. METHODS: Lymphatic vessels were stained immunohistochemically with monoclonal a...