XLMR

作品数：2被引量：22H指数：2
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相关领域：医药卫生更多>>
相关作者：张靖更多>>
相关机构：中国科学院大学西北大学辽宁大学更多>>
相关期刊：《Cell Research》更多>>
相关基金：国家重点基础研究发展计划更多>>
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The X-linked mental retardation gene PHF8 is a histone demethylase involved in neuronal differentiation被引量：16
《Cell Research》2010年第8期908-918,共11页Jihui Qiu Guang Shi Yuanhui Jia Jing Li Meng Wu Jiwen Li Shuo Dong Jiemin Wong 
Recent studies have identified mutations in PHF8, an X-linked gene encoding a JmjC domain-containing protein, as a causal factor for X-linked mental retardation （XLMR） and cleft lip/cleft palate. However, the underl...
关键词：PHF8 histone demethylase COACTIVATOR XLMR neuronal differentiation 
Structural insights into a novel histone demethylase PHF8被引量：11
《Cell Research》2010年第2期166-173,共8页Lin Yu Yang wang Shuo Huang Jianjun Wang Zengqin Deng Qi Zhang Wei Wu Xingliang Zhang Zhao Liu Weimin Gong Zhongzhou Chen 
Supplementary information is linked to the online version of the paper on the Cell Research website.Acknowledgments We thank Dr Dawei Li （China Agricultural University） for generously providing us with the experimental conditions during the early stages of this project. We thank Dr Ruiming Xu （Institute of Biophysics, Chinese Academy of Sciences） for critical reading of this manuscript and advice. We thank Dr Pinchao Mei （Chinese Academy of Medical Sciences and Peking Union Medical College）, Xinqi Liu （Nankai University） and Jiemin Wong （East China Normal University） for discussions and advice. The synchrotronradiation experiments were performed at Shanghai Synchrotron Radiation Facility （SSRF） and NE3A in the Photon Factory. Z.C. is supported by the National Basic Research Program of China （973 Program, 2009CB825501）, the National Natural Science Foundation of China （30870494 and 90919043）, the New Century Excellent Talents in University （NCET-07-0808） and the Innovative Project of SKLAB. S. H. is supported by the National Key Laboratory Special Fund 2060204. Z. D. is supported by the National Natural Science Foundation of China （J0730639）.
Dynamic regulation of histone methylation/demethylation plays an important role during development. Mutations and truncations in human plant homeodomain （PHD） finger protein 8 （PHF8） are associated with X-linked m...
关键词：PHF8 （PHD finger protein 8） histone demethylase chromatin modification methylated H3K9 crystal structure X-linked mental retardation （XLMR） facial anomalies 
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