COACTIVATOR

作品数：63被引量：219H指数：8
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相关领域：医药卫生更多>>
相关作者：周度金王峰刘坤王薇李文岗更多>>
相关机构：第三军医大学中山大学附属第一医院中山大学厦门大学更多>>
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相关基金：国家自然科学基金重庆市自然科学基金中国博士后科学基金国家重点基础研究发展计划更多>>
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Electroacupuncture alleviates diabetic peripheral neuropathy through modulating mitochondrial biogenesis and suppressing oxidative stress
《World Journal of Diabetes》2025年第2期133-150,共18页Chong-Xi Yuan Xuan Wang Yun Liu Tian-Cheng Xu Zhi Yu Bin Xu 
National Natural Science Foundation of China,No.82074532,No.82374577,No.82305375,No.82305376,and No.82405567;The Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD).
BACKGROUND Peripheral neuropathy caused by diabetes is closely related to the vicious cycle of oxidative stress and mitochondrial dysfunction resulting from metabolic abnormalities.The effects mediated by the silent i...
关键词：ELECTROACUPUNCTURE Type 2 diabetic peripheral neuropathy Silent matching type information regulation 2 homolog-1/peroxisome proliferator-activated receptor-gamma coactivator-1αaxis Mitochondria biogenesis Oxidative stress 
Transcription coactivator YAP1 promotes CCND1/CDK6 expression,stimulating cell proliferation in cloned cattle placentas
《Zoological Research》2025年第1期122-138,共17页Shan-Shan Wu Xiao-Yu Zhao Lei Yang Chao Hai Di Wu Xue-Fei Liu Li-Shuang Song Chun-Ling Bai Guang-Hua Su Guang-Peng Li 
supported by the National Natural Science Foundation of China (32060755);Natural Science Foundation of Inner Mongolia (2024MS03001);Inner Mongolia Autonomous Region Open Competition Projects (2022JBGS0018);Program for Young Talents of Science and Technology in Universities of Inner Mongolia Autonomous Region (NJYT23090);Inner Mongolia Autonomous Region Science and Technology Leading Team (2022LJRC0006);Inner Mongolia Autonomous Region Science and Technology Major Project (2021ZD0009);Major Agricultural Science and Technology Project of the Ministry of Agriculture and Rural Affairs (NK2022130203);Central Government Guides Local Science and Technology Development Funds (2022ZY0212);Inner Mongolia Autonomous Region High-level Talent Support Program;Inner Mongolia University Chief Scientist Program。
Somatic cell nuclear transfer(SCNT)has been successfully employed across various mammalian species,yet cloned animals consistently exhibit low pregnancy rates,primarily due to placental abnormalities such as hyperplas...
关键词：Somatic cell nuclear transfer Cloned cattle Placental hypertrophy Cell proliferation CCND1-CDK6 YAP1 
Coactivator-independent vitamin D receptor signaling causes severe rickets in mice,that is not prevented by a diet high in calcium,phosphate,and lactose
《Bone Research》2024年第3期648-660,共13页Stefanie Doms Lieve Verlinden Iris Janssens Justine Vanhevel Roy Eerlings RenéHoutman Shigeaki Kato Chantal Mathieu Brigitte Decallonne Geert Carmeliet Annemieke Verstuyf 
the University of Leuven (C16/18/006);the Flanders Research Foundation (FWO;G0D0120N,G0D4217N and G081723N)。
The vitamin D receptor(VDR)plays a critical role in the regulation of mineral and bone homeostasis.Upon binding of 1α,25-dihydroxyvitamin D_(3) to the VDR,the activation function 2(AF2)domain repositions and recruits...
关键词：VITAMIN HOMEOSTASIS POSITIONS 
Transcription factor EHF interacting with coactivator AJUBA aggravates malignancy and acts as a therapeutic target for gastroesophageal adenocarcinoma
《Acta Pharmaceutica Sinica B》2024年第5期2119-2136,共18页Li Peng Yanyi Jiang Hengxing Chen Yongqiang Wang Qiusheng Lan Shuiqin Chen Zhanwang Huang Jingyuan Zhang Duanqing Tian Yuntan Qiu Diankui Cai Jiangyun Peng Daning Lu Xiaoqing Yuan Xianzhu Yang Dong Yin 
This work was supported by grants from the National Key Research and Development Program of China(2021YFA0909300 to Dong Yin);the National Natural Science Foundation of China(82372617,81972658 and 81802812 to Li Peng,81803636 to Xiaoqing Yuan,82073067 and 81872140 to Dong Yin);Guangdong Basic and Applied Basic Research Foundation(2024B1515020090,2023A1515012683,2019A1515012114 and 2018A030313129 to Li Peng,2024A1515030038 to Xiaoqing Yuan,2021A0505030084 and 2019B020226003 to Dong Yin);Basic and Applied Basic Research of Guangzhou Municipal Basic Research Plan(2024A03J0845 and 2023A04J2098 to Li Peng);National Postdoctoral Program for Innovation Talents(grant no.BX20190395 to Li Peng);China Postdoctoral Science Foundation(grant no.2019M663254 to Li Peng);the Fundamental Research Funds for the Central Universities(grant no.20ykpy105 to Li Peng);the Science and Technology Planning Project of Guangdong Province(2023B1212060013 and 2020B1212030004).
Transcriptional dysregulation of genes is a hallmark of tumors and can serve as targets for cancer drug development.However,it is extremely challenging to develop small-molecule inhibitors to target abnormally express...
关键词：EHF AJUBA KRAS pathway Enhancer Core transcriptional regulatory circuitry Gastroesophageal adenocarcinoma Gastric adenocarcinoma Esophageal adenocarcinoma Transcription factor COACTIVATOR Lipid nanoparticles 
Mechanism of acupuncture in attenuating cerebral ischaemia-reperfusion injury based on nuclear receptor coactivator 4 mediated ferritinophagy被引量：3
《Journal of Traditional Chinese Medicine》2024年第2期345-352,共8页ZHANG Xinchang HUANG Zheng HUANG Peiyan YANG Mengning ZHANG Zhihui NI Guangxia 
the National Natural Science Foundation of China:Mechanism of Acupuncture in Extending Thrombolytic Time Window of Cerebral Infarction Based on Nuclear Receptor Coactivator 4 Mediated Ferritinophagy(No.82205238);National Natural Science Foundation of China:Exploring the Mechanism of Acupuncture Improving Thrombolytic Safety in Cerebral Infarction through the ERK1/2-mTOR Pathway Based on Autophagy Apoptosis Interaction(No.82074525);Natural Science Foundation of Jiangsu Province:Experimental Study on Acupuncture Regulation of Ferroptosis-NLRP3 Inflammasome Pathway to Reduce Hemorrhagic Transformation after Thrombolysis in Cerebral Infarction(No.BK20210689);Traditional Chinese Medicine Science and Technology Development Plan Project of Jiangsu Province:Clinical and Experimental Study on Acupuncture Improving the Safety of rt-PA Intravenous Thrombolysis in Cerebral Infarction(No.YB2020005)。
OBJECTIVE:To explore the effect of acupuncture treatment on cerebral ischaemia-reperfusion injury(CIRI)and reveal the underlying mechanism of the effect based on nuclear receptor coactivator 4(NCOA4)mediated ferritino...
关键词：ACUPUNCTURE ferritinophagy ferroptosis FERRITIN nuclear receptor coactivator 4 cerebral ischaemia-reperfusion injury 
Peroxisome proliferator-activated receptor gamma coactivator-1(PGC-1)family in physiological and pathophysiological process and diseases被引量：7
《Signal Transduction and Targeted Therapy》2024年第4期1249-1292,共44页Lu Qian Yanli Zhu Chao Deng Zhenxing Liang Junmin Chen Ying Chen Xue Wang Yanqing Liu Ye Tian Yang Yang 
supported by the National Natural Science Foundation of China (82360716,82070422,and 82200330);China Postdoctoral Science Foundation (2023T160526 and 2022M722571);Research Plan Project of Shaanxi Institute of Basic Science (22JHQ053);High-end Foreign Expert Introduction Program of National Science and Technology (G2022040014L);Qinchuangyuan Traditional Chinese Medicine Innovation Research and Development Transformation Project (2022-QCYZH-036).
Peroxisome proliferator-activated receptor gamma coactivator-1(PGC-1)family(PGC-1s),consisting of three members encompassing PGC-1a,PGC-1β,and PGC-1-related coactivator(PRC),was discovered more than a quarter-century...
关键词：DISEASES life PRECISE 
Activation of G-protein-coupled receptor 39 reduces neuropathic pain in a rat model被引量：2
《Neural Regeneration Research》2024年第3期687-696,共10页Longqing Zhang Xi Tan Fanhe Song Danyang Li Jiayi Wu Shaojie Gao Jia Sun Daiqiang Liu Yaqun Zhou Wei Mei 
supported by the National Notural Science Foundation of China,Nos.82071556 and 82271291 (both to WM)
Activated G-protein-coupled receptor 39(GPR39)has been shown to attenuate inflammation by interacting with sirtuin 1(SIRT1)and peroxisome proliferator-activated receptor-γcoactivator 1α(PGC-1α).However,whether GPR3...
关键词：G-protein-coupled receptor 39(GPR39) NEUROINFLAMMATION neuropathic pain nuclear respiratory factor 1(NRF1) peroxisome proliferator-activated receptor-γcoactivator 1α(PGC-1α) sirtuin 1(SIRT1) spinal cord mitochondrial transcription factor A(TFAM) 
Nuclear receptor coactivator 6 is a critical regulator of NLRP3 inflammasome activation and gouty arthritis被引量：1
《Cellular & Molecular Immunology》2024年第3期227-244,共18页Kang-Gu Lee Bong-Ki Hong Saseong Lee Naeun Lee Seung-Whan Kim Donghyun Kim Wan-Uk Kim 
supported by grants from the National Research Foundation of Korea(NRF)funded by the Ministry of Science and ICT(2015R1A3A2032927 and 2021R1A2C1008130).
Transcriptional coactivators regulate the rate of gene expression in the nucleus.Nuclear receptor coactivator 6(NCOA6),a coactivator,has been implicated in embryonic development,metabolism,and cancer pathogenesis,but ...
关键词：Nuclear receptor coactivator 6 Nuclear-to-cytoplasmic translocation NLRP3 inflammasome NACHT domain Gouty arthritis 
Peroxisome Proliferator-Activated Receptor-γCoactivator-1αin the Spotlight with Multiple Sclerosis
《Neuroscience Bulletin》2024年第2期268-272,共5页Ya-Na Yang Mao-Qing Zhang Feng-Lin Yu Bing Han Ming-Yue Bao Yan He Xing Li Yuan Zhang 
supported by the National Natural Science Foundation of China(92268118,82071396,82271199,and 31970771);the Shaanxi Provincial Key R&D Foundation(2021ZDLSF03-09);the Fundamental Research Funds for the Central Universities(GK202201013,GK202202006,and GK202105002);the Tian Jia Bing Scholar Program.
Multiple sclerosis(MS)is a chronic and incurable autoimmune disease of the central nervous system(CNS)that results in neuro-inflammation and demyelination.Current therapies for MS alleviate symptoms to some extent but...
关键词：INFLAMMATION MYELIN AUTOIMMUNE 
Irisin/BDNF signaling in the muscle-brain axis and circadian system: A review被引量：1
《The Journal of Biomedical Research》2024年第1期1-16,共16页Alexey N.Inyushkin Vitalii S.Poletaev Elena M.Inyushkina Igor S.Kalberdin Andrey A.Inyushkin 
supported by the Russian Science Foundation(Grant No.23-25-00152).
In mammals,the timing of physiological,biochemical and behavioral processes over a 24-h period is controlled by circadian rhythms.To entrain the master clock located in the suprachiasmatic nucleus of the hypothalamus ...
关键词：irisin brain-derived neurotrophic factor peroxisome proliferator-activated receptorγcoactivator 1α circadian rhythm circadian system muscle-brain axis 
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