MICROCEPHALY

作品数：46被引量：50H指数：4
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相关机构：福州大学更多>>
相关期刊：《Chinese Medical Journal》《Advances in Microbiology》《Open Journal of Ophthalmology》《Acta Epileptologica》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划上海市自然科学基金更多>>
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Transfer of convalescent serum to pregnant mice prevents Zika virus infection and microcephaly in offspring被引量：2
《Cell Research》2017年第1期158-160,共3页Shuo Wang Shuai Hong Yong-Qiang Deng Qing Ye Ling-Zhai Zhao Fu-Chun Zhang Cheng-Feng Qin Zhiheng Xu 
This work was supported by the National Natural Science Foundation of China （31430037, 31271156, 81522025 and 81621005）, the National Basic Research Program （＂973＂ program;2014CB942801, 2013DFA31990 and 2012YQ03026006） and the National Key Research Program of China （2016YFD0500304）.
Zika virus （ZIKV） is spreading rapidly around the world in over 60 countries. There is a mounting concern over the association of ZIKV infection and devastating cases of fetal and newborn microcephaly cases [1]. The...
关键词：病毒感染 畸形 恢复期 后代 老鼠 怀孕 血清 胎脑组织 
TALEN-based generation of a cynomolgus monkey disease model for human microcephaly被引量：13
《Cell Research》2016年第9期1048-1061,共14页Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang 
Acknowledgments This work was supported by the National Basic Research Program of China （2012CBA01302）, the National Natural Science Foundation of China （81425016, 31301219 and 81570593）, the Fundamental Research Funds for the Central Universities （15ykjc01c）, PhD Programs Foundation of Ministry of Education of China （20130171120061）, the Key Scientific and Technological Projects of Guangdong Province （2014B020226002, 2014B020228003, 2014B020225007, 2015B020228002 and 2016B030229002）, Key Scientific and Technological Program of Guangzhou City （201400000003-3, 201508020262, 201300000089 and 2010U 1-E00551）, Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme （GDUPS, 2013） and Pearl River S＆T Nova Program of Guangzhou （2014J2200037）.
Gene editing in non-human primates may lead to valuable models for exploring the etiologies and therapeutic strategies of genetically based neurological disorders in humans. However, a monkey model of neurological dis...
关键词：MCPH1 MICROCEPHALY TALEN gene mutant cynomolgus monkey 
A distinct response to endogenous DNA damage in the development of Nbsl-deficient cortical neurons被引量：2
《Cell Research》2012年第5期859-872,共14页Rui Li Yun-Gui Yang Yunzhou Gao Zhao-Qi Wang Wei-Min Tong 
Microcephaly is a clinical characteristic for human nijmegen breakage syndrome （NBS, mutated in NBS1 gene）, a chromosomal instability syndrome. However, the underlying molecular pathogenesis remains elusive. In the ...
关键词：DNA damage response Nbsl MICROCEPHALY p53 Hzf 
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