NANO-LC

作品数：7被引量：14H指数：2
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相关领域：医药卫生生物学更多>>
相关作者：杜明贾滨于翠平徐献兵杨芃原更多>>
相关机构：澳门科技大学大连工业大学复旦大学江西中医药大学更多>>
相关期刊：《Journal of Ocean University of China》《Chinese Journal of Natural Medicines》《中国实验方剂学杂志》《Journal of Pharmaceutical Analysis》更多>>
相关基金：国家自然科学基金国家高技术研究发展计划江西省自然科学基金国家重点基础研究发展计划更多>>
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基于NANO-LC-MS/MS和生物信息学的抗特发性肺纤维化靶点的筛选与验证
《中国药学杂志》2022年第20期1733-1741,共9页宋蔚 吴柳莹 张文婷 胡晓艺 杜晓月 王梦雅 郑雪瑶 左佩文 彭志红 
药物高通量筛选技术国家地方联合工程研究中心开放基金项目资助(M20202006;K20202001)。
目的利用生物信息技术检索特发性肺纤维化(idiopathic pulmonary fibrosis,IPF)基因芯片数据,并结合体外实验,筛选与验证IPF相关的蛋白,为该疾病的药物开发提供潜在的作用靶点。方法采用基因表据库(Gene Expression Omnibus,GEO)检索“...
关键词：特发性肺纤维化 生物信息技术 细胞外基质 纳升级液质联用 
Recent Advances on Chiral Mobile Phase Additives: A Critical Review被引量：1
《Journal of Analysis and Testing》2022年第2期129-162,共34页Yuan Li Xiao-Ning Jin Yue Cheng Xiao-Fei Ma Yong Wang 
financially funded by the National Key R&D Program of China(2019YFC1905500);the National Natural Science Foundation of China(21922409,21976131);Tianjin Research Program of Application Foundation and Advanced Technology(18JCZDJC37500)
Chirality is one of the fundamental attributes of nature, which exists in different or even completely opposite metabolic,toxicological and pharmacological properties in organisms. Consequently, obtaining enantiomeric...
关键词：Chiral mobile phase additives High-performance liquid chromatography(HPLC) Capillary electrophoresis(CE) Countercurrent chromatography(CCC) Nano-liquid chromatography(Nano-LC) 
Determination of L-norvaline and L-tryptophan in dietary supplements by nano-LC using an O-[2-(methacryloyloxy)-ethylcarbamoyl]-10,11- dihydroquinidine-silica hybrid monolithic column被引量：1
《Journal of Pharmaceutical Analysis》2020年第1期70-77,共8页Dongsheng Xu Elena Sanchez-Lopez Qiqin Wang Zhengjin Jiang María Luisa Marina 
An analytical methodology based on an O-[2-(methacryloyloxy)-ethylcarbamoyl]-10,11-dihydroquinidine(MQD)-silica hybrid monolithic column was developed for the enantioseparation of 9-fluorenylmethoxycarbonyl(FMOC)deriv...
关键词：9-Fluorenylmethoxycarbonyl Amino acids Chiral separation NANO-LC Quinidine-silica hybrid monolithic column 
基于nano-LC-LTQ/Orbitrap-MS筛选黄芩-黄连药对干预2型糖尿病KKAy小鼠的骨骼肌差异表达蛋白被引量：9
《中国实验方剂学杂志》2018年第17期126-131,共6页刘彤彤 肖琴 盛军庆 涂秀英 孙军 魏学鑫 于梅 章常华 
国家自然科学基金项目(81460622,81774194,81260660);江西省自然科学基金项目(20171BAB205095,20151BAB205079,20151BAB205077);江西省卫生计生委科研计划项目(2016A024)
目的采用nano-LC-LTQ／Orbitrap．MS鉴定2型糖尿病KKAy小鼠模型组与给药组的骨骼肌差异表达蛋白，推测黄芩-黄连药对（sc）防治2型糖尿病的作用机制。方法：取20只8-10周龄的雄性KKAy小鼠，给予全价高脂饲料，随机等分为2组，分别为黄芩...
关键词：黄芩一黄连 药对 KKAY小鼠 蛋白质组学 差异表达蛋白 
Characterization of Angiotensin-? Converting Enzyme Inhibiting Peptide from Venerupis philippinarum with Nano-Liquid Chromatography in Combination with Orbitrap Mass Spectrum Detection and Molecular Docking被引量：2
《Journal of Ocean University of China》2017年第3期473-478,共6页SHI Lei WU Tizhi SHENG Naijuan YANG Li WANG Qian LIU Rui WU Hao 
supported by the Public Science and Technology Research Funds (Projects of Ocean);State Ocean Administration of P. R. China (Nos. 201305007 and 201405017);National High Technology Research and Development Program of China (No. 2013AA093003);the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD);Jiangsu Qinglan Project;Jiangsu 333 Project
The complexity and diversity of peptide mixture from protein hydrolysates make their characterization difficult. In this study, a method combining nano LC-MS/MS with molecular docking was applied to identifying and ch...
关键词：ACE-I inhibitor ACE-I inhibiting peptide CHARACTERIZATION nano-LC-MS/MS molecular docking Venerupis philippinarum 
Nano-LC-ESI MS/MS analysis of proteins in dried sea dragon Solenognathus hardwickii and bioinformatic analysis of its protein expression profiling被引量：1
《Chinese Journal of Natural Medicines》2016年第9期709-713,共5页ZHANG Dong-Mei FENG Li-Xing LI Lu LIU Miao JIANG Bao-Hong YANG Min LI Guo-Qiang WU Wan-Ying GUO De-An LIU Xuan 
supported in part by the National High Technology Research and Development Program of China(No.2013AA093002);Shanghai Science&Technology Support Program(No.13431900401);Shanghai Science&Technology Innovation Action Program(No.15140904800);the National Nature Science Foundation of China(No.81373964);the National Science&Technology Major Project of China(No.2014ZX09301-306-03)
The sea dragon Solenognathus hardwickii has long been used as a traditional Chinese medicine for the treatment of various diseases, such as male impotency. To gain a comprehensive insight into the protein components o...
关键词：Sea dragon Solenognathus hardwickii Mass-spectrometry-based proteomics Bioinformatic analysis 
Particulate capillary precolumns with double-end polymer monolithic frits for on-line peptide trapping and preconcentration
《Chinese Chemical Letters》2015年第9期1068-1072,共5页Si-Min Xia Hui-Ming Yuan Zheng Liang Li-Hua Zhang Yu-Kui Zhang 
the financial support from National Basic Research Program of China(No.2012CB910604);National Natural Science Foundation of China(No.20935004);the Creative Research Group Project by NSFC(No.21321064);National High Technology Research and Development Program of China (No.2012AA020202)
In this work,a novel kind of particulate capillary precolumns with double-end polymer monolithic frits has been developed.Firstly,the polymer monolithic frit at one end was prepared via photo-initiated polymerization ...
关键词：Capillary precolumn Double-end frits Peptide trapping 2D nano-LC 
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