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  • 期刊=Signal Transduction and Targeted Therapyx
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Safety,immunogenicity and protective effect of sequential vaccination with inactivated and recombinant protein COVID-19 vaccine in the elderly:a prospective longitudinal study
《Signal Transduction and Targeted Therapy》2024年第6期2738-2747,共10页Hong-Hong Liu Yunbo Xie Bao-Peng Yang Huan-Yue Wen Peng-Hui Yang Jin-E Lu Yan Liu Xi Chen Meng-Meng Qu Yang Zhang Wei-Guo Hong Yong-Gang Li Junliang Fu Fu-Sheng Wang 
supported by Guangzhou Laboratory,Grant Award Number:EKPG21-30-4.
The safety and efficacy of COVID-19 vaccines in the elderly,a high-risk group for severe COVID-19 infection,have not been fully understood.To clarify these issues,this prospective study followed up 157 elderly and 73 ...
关键词：VACCINATION VACCINE doses 
Generation of inactivated IL2RG and RAG1 monkeys with severe combined immunodeficiency using base editing
《Signal Transduction and Targeted Therapy》2023年第10期4825-4837,共13页Xiao Zheng Chunhui Huang Yingqi Lin Bofeng Han Yizhi Chen Caijuan Li Jiawei Li Yongyan Ding Xichen Song Wei Wang Weien Liang Jianhao Wu Jiaxi Wu Jiale Gao Chengxi Wei Xudong Zhang Zhuchi Tu Sen Yan 
This work was supported by the National Key Research and Development Program of China(2021YFA0805300,2021YFA0805204);the National Natural Science Foundation of China(82171244,81922026,32170981);Guangzhou Key Research Program on Brain Science(202007030008).
Severe combined immunodeficiency(SCiD)encompasses a range of inherited disorders that lead to a profound deterioration of the immune system.Among the pivotal genes associated with SCID,RAG1 and IL2RG play crucial role...
关键词：IMMUNODEFICIENCY IMMUNITY RAG1 
Waning humoral immune responses to inactivated SARS-CoV-2 vaccines in patients with severe liver disease被引量：2
《Signal Transduction and Targeted Therapy》2022年第7期2138-2140,共3页Zhiwei Chen Yingzhi Zhang Rui Song Lu Wang Xiaoxiao Hu Hu Li Dachuan Cai Peng Hu Xiaofeng Shi Hong Ren 
supported by the National Science and Technology Major Project of China(2017ZX10202203-007,2017ZX10202203-008,2018ZX10302206-003);a pilot project of clinical cooperation between traditional Chinese and western medicine for significant and complicated diseases of National Administration of Traditional Chinese Medicine:hepatic fibrosis;support of the National Natural Science Foundation of China(81772198),Natural Science Foundation of Chongqing,China(cstc2020jcyj-msxmX0389).
Dear Editor,The Coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is still ongoing around the world.Patients with severe liver disease(SLD),such as compens...
关键词：PATIENTS vaccines PREVENTION 
Inactivated SARS-CoV-2 induces acute respiratory distress syndrome in human A CE2-transgenic mice
《Signal Transduction and Targeted Therapy》2022年第1期310-321,共12页Zhenfei Bi Weiqi Hong Haiying Que Cai He Wenyan Ren Jingyun Yang Tianqi Lu Li Chen Shuaiyao Lu Xiaozhong Peng Xiawei Wei 
This work is supported by the National Natural Science Foundation Regional Innovation and Development(No.U19A2003);National Major Scientific and Technological Special Project for"Significant New Drugs Development"(No.2018ZX09733001);the Excellent Youth Foundation of Sichuan Scientific Committee Grant in China(No.2019JDJQ008);the Development Program of China(No.2016YFA0201402).
The development of animal models for COVID-19 is essential for basic research and drug/vaccine screening.Previously reported COVID-19 animal models need to be established under a high biosafety level condition for the...
关键词：DISTRESS LUNG ROUTINE 
A novel inactivated whole-cell Pseudomonas aeruginosa vaccine that acts through the cGAS-STING pathway被引量：3
《Signal Transduction and Targeted Therapy》2021年第11期3256-3269,共14页Cuicui Ma Xiao Ma Boguang Jiang Hailong Pan Xueyuan Liao Li Zhang Wenfang Li Yingjie Luo Zhixue Shen Xingjun Cheng Mao Lian Zhenling Wang 
This study was supported by the Chinese Major Scientific and Technological Special Project for“Significant New Drugs Creation”,National Key Project(2019ZX09721-001-004-004);Key Technologies and Transformation Platform for Rapid Emergency Vaccine R&D for“the Sichuan Province Key R&D Program”(2020YFS0568).
Pseudomonas aeruginosa infection continues to be a major threat to global public health,and new safe and efficacious vaccines are needed for prevention of infections caused by P.aeruginosa.X-ray irradiation has been u...
关键词：VACCINE prevention utilized 
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