Background: Dysfunctional spinal circuit may play a role in the pathophysiology ofarnyotrophic lateral sclerosis (ALS). The purpose of this study was to use F waves for assessment of segmental motoneuronal excitabi...
supported by Direct Grant (Project No.2030392) of the Chinese University of Hong Kong;HK Spinal Cord Injury Foundation;National Key Basic Research Support Foundation (973 Project: 2011CB504402)
The neurotrophin receptor (p75) activates the c-Jun N-terminal kinase (JNK) pathway. Activation of JNK and its substrate c-Jun can cause apoptosis. Here we evaluate the role of p75 in spinal motoneurons by compari...