Γ-SECRETASE

作品数：23被引量：59H指数：5
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相关领域：医药卫生更多>>
相关作者：殷莹曹鹏缪凤琴于春泳梁国标更多>>
相关机构：东南大学清华大学第二军医大学台湾大学更多>>
相关期刊：《National Science Review》《Advances in Bioscience and Biotechnology》《Acta Biochimica et Biophysica Sinica》《Medicinal Plant》更多>>
相关基金：国家自然科学基金World Health Organization更多>>
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Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease
《Neural Regeneration Research》2025年第1期174-180,共7页Yinglong Miao Michael S.Wolfe 
supported in part by Award 2121063 from National Science Foundation(to YM);AG66986 from the National Institutes of Health(to MSW).
γ-Secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the ...
关键词：Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics NOTCH 
Presenilin mutations and their impact on neuronal differentiation in Alzheimer’s disease
《Neural Regeneration Research》2022年第1期31-37,共7页Mercedes A.Hernández-Sapiéns Edwin E.Reza-Zaldívar Ana L.Márquez-Aguirre Ulises Gómez-Pinedo Jorge Matias-Guiu Ricardo R.Cevallos Juan C.Mateos-Díaz Víctor J.Sánchez-González Alejandro A.Canales-Aguirre 
supported by the Consejo Nacional de Ciencia y Tecnología Scholarship 711893(to MAH)and 711874(to EER)。
The presenilin genes(PSEN1 and PSEN2)are mainly responsible for causing early-onset familial Alzheimer’s disease,harboring~300 causative mutations,and representing~90%of all mutations associated with a very aggressiv...
关键词：familial Alzheimer’s disease familial Alzheimer’s disease-induced pluripotent stem cells models induced pluripotent stem cells neurogenesis neuronal differentiation Notch presenilin 1 PSEN1 mutations γ-secretase complex 
Huannao Yicong Formula (还脑益聪方) Regulates γ-Secretase Activity through APH-1 and PEN-2 Gene Raguiation Pathways in Hippocampus of APP/PS1 Double Transgenic Mice被引量：5
《Chinese Journal of Integrative Medicine》2017年第4期270-278,共9页WANG Zhi-yong LIU Jian-gang WEI Yun LIU Mei-xia WANG Qi LIANG Lin YANG Hui-min LI Hao 
Supported by the National Natural Science Foundation of China(No.81173383 and No.81573819);Beijing Municipal Science and Technology Plan "Ten Disease and Ten Medicine"(No.Z141100002214003)
Objective To observe the effects of Huannao Yicong Formula (还脑益聪方, HYF) on learning and memory and it’s regulating effect on γ-secretase related anterior pharynx defective 1 (APH-1), presenilin enhancer-2 (PEN-...
关键词：Huannao Yicong Formula Alzheimer’s disease Γ-SECRETASE Β-AMYLOID 
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