HEPATOCELLULAR

作品数：1273被引量：7979H指数：37
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相关作者：张福君张亮吴沛宏顾仰葵赵明更多>>
相关机构：第二军医大学中山大学中国人民解放军总医院广州军区广州总医院更多>>
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  • 期刊=Signal Transduction and Targeted Therapyx
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Envafolimab plus lenvatinib and transcatheter arterial chemoembolization for unresectable hepatocellular carcinoma:a prospective,single-arm,phase II study被引量：1
《Signal Transduction and Targeted Therapy》2024年第11期5183-5192,共10页Yiwen Chen Junlei Zhang Wendi Hu Xiang Li Ke Sun Yan Shen Min Zhang Jian Wu Shunliang Gao Jun Yu Risheng Que Yun Zhang Fuchun Yang Weiliang Xia Aibin Zhang Xiaofeng Tang Xueli Bai Tingbo Liang 
supported by grants from the National Natural Science Foundation of China(No.82172859,82071916,U20A20378,and 82188102);the Joint Fund for Regional Innovation and Development of National Natural Science Foundation of China(No.U23A20462).
Evidences regarding the feasibility of transcatheter arterial chemoembolization(TACE)-based therapy for unresectable hepatocellular carcinoma(uHCC)remains limited.This study aimed to investigate the efficacy and safet...
关键词：TRANSCATHETER HEPATOCELLULAR ARTERIAL 
The p-MYH9/USP22/HIF-1α axis promotes lenvatinib resistance and cancer stemness in hepatocellular carcinoma被引量：1
《Signal Transduction and Targeted Therapy》2024年第10期4614-4627,共14页Qiaonan Shan Lu Yin Qifan Zhan Jiongjie Yu Sheng Pan Jianyong Zhuo Wei Zhou Jiaqi Bao Lincheng Zhang Jiachen Hong Jianan Xiang Qingyang Que Kangchen Chen Shengjun Xu Jingrui Wang Yangbo Zhu Bin He Jingbang Wu Haiyang Xie Shusen Zheng Tingting Feng Sunbin Ling Xiao Xu 
National Key Research and Development Program of China(2022YFA1106800),National Natural Science Foundation of China(82203070,82200726,82200727,92159202 and 82273270);Project of Medical and Health Technology Program in Zhejiang Province(2024KY853).
Lenvatinib is a targeted drug used for first-line treatment of hepatocellular carcinoma(HCC).A deeper insight into the resistance mechanism of HCC against lenvatinib is urgently needed.In this study,we aimed to dissec...
关键词：USP22 HEPATOCELLULAR diagnosis 
Hypoxia-induced nuclear localization of ubiquinol-cytochrome-c reductase complex assembly factor 3(UQCC3)in hepatocellular carcinoma
《Signal Transduction and Targeted Therapy》2024年第8期3173-3175,共3页Yun Yang Yinhao Wei Yiying Sun Yong Zhou Hanshuo Yang 
This work was supported by grants from National Natural Science Foundation of China(81572402);Discipline Excellence Development 1-3-5 Project of West China Hospital,Sichuan University(ZYJC21031);Transfer Payment Project of Tianfu Laboratory under Sichuan Science and Technology Plan(JH2022001);the 70th batch of general funding list of China Postdoctoral Science Foundation(2021M702327);the Sichuan University postdoctoral interdisciplinary innovation Fund.
Dear Editor,The mitochondrion plays crucial roles in cellular energy generation and signaling transduction.Increasing studies have shown that nuclear-encoded mitochondrial proteins translocate into the nucleus to regu...
关键词：HEPATOCELLULAR RETROGRADE communicate 
Semaphorin 3C (Sema3C) reshapes stromal microenvironment to promote hepatocellular carcinoma progression被引量：1
《Signal Transduction and Targeted Therapy》2024年第8期3429-3448,共20页Hao Peng Meng Yang Kun Feng Qingpeng Lv Yewei Zhang 
This study was supported by the National Natural Science Foundation of China(Nos.62331016,62227803,U22A2023,62325112);the Leading-edge Technology Programme of Jiangsu Natural Science Foundation:BE2022812,BK20212021。
More than 90% of hepatocellular carcinoma(HCC)cases develop in the presence of fibrosis or cirrhosis,making the tumor microenvironment(TME)of HCC distinctive due to the intricate interplay between cancer-associated fi...
关键词：SEMA HEPATOCELLULAR thereby 
A novel engineered IL-21 receptor arms T-cell receptor-engineered T cells(TCR-T cells)against hepatocellular carcinoma被引量：3
《Signal Transduction and Targeted Therapy》2024年第5期2215-2230,共16页Wei Zhu Zhiming Zhang Jinzhang Chen Xiaolan Chen Lei Huang Xiaoyong Zhang Xuan Huang Na Ma Weikang Xu Xuan Yi Xinyu Lu Xin Fu Siwei Li Guoheng Mo Yiyue Wang Guosheng Yuan Mengya Zang Qi Li Xiaotao Jiang Yajing He Sha Wu Yukai He Yongyin Li Jinlin Hou 
The study was sponsored by the National Key Research and Development Program of China(No.2022YFC2303600);the National Natural Science Foundation of China(82073360 and 81802449);the Guangdong Basic and Applied Basic Research Foundation(2023A1515012169,2021A1515220100,2020A1515011313);the Outstanding Youth Development Scheme of Nanfang Hospital,Southern Medical University(2020J004).
Strategies to improve T cell therapy efficacy in solid tumors such as hepatocellular carcinoma(HCC)are urgently needed.The common cytokine receptorγchain(γc)family cytokines such as IL-2,IL-7,IL-15 and IL-21 play fu...
关键词：HEPATOCELLULAR TCR utilize 
Retraction Note:Dickkopf-1 contributes to hepatocellular carcinoma tumorigenesis by activating the Wnt/β-catenin signaling pathway被引量：1
《Signal Transduction and Targeted Therapy》2023年第6期3188-3188,共1页Rui Zhang Hao-Ming Lin Ruth Broering Xiang-de Shi Xian-huan Yu Lei-bo Xu Wen-rui Wu Chao Liu 
Retraction to:Signal Transduction and Targeted Therapy https://doi.org/10.1038/s41392-019-0082-5,published online 06 December 2019 The authors have retracted this article.After publication,concerns were raised regardi...
关键词：Therapy HEPATOCELLULAR raised 
ALYREF mediates RNA m^(5)C modification to promote hepatocellular carcinoma progression被引量：5
《Signal Transduction and Targeted Therapy》2023年第4期1375-1377,共3页Chen Xue Xinyu Gu Qiuxian Zheng Qingmiao Shi Xin Yuan Yuanshuai Su Junjun Jia Jianwen Jiang Juan Lu Lanjuan Li 
the National Key Research and Development Program of China(81790631);Zhejiang Province Health Department Program(2021KY657).
Dear Editor,The incidence of hepatocellular carcinoma(HCC)is increasing in many countries due to hepatic virus infection and unhealthy diet habits,and the unsatisfactory overall survival rate calls for novel treatment...
关键词：HEPATOCELLULAR diagnosis LIKELY 
Combating inconsistent evaluation of intra-tumor immune status by a novel transcriptomic signature in hepatocellular carcinoma
《Signal Transduction and Targeted Therapy》2023年第3期895-897,共3页Linmeng Zhang Ning Tang Chen Yang Haigang Geng Hualian Hang Wenxin Qin Cun Wang 
This work was supported by the National Natural Science Foundation of China(81920108025,81874229,82072633,and 82122047);the Innovative Research Team of High-level Local Universities in Shanghai(SHSMU-ZLCX20211602);Shanghai Natural Science Foundation(22ZR1480900).
Dear Editor,Harnessing the power of the immune system via immune checkpoint inhibition has revolutionized the treatment paradigm of many malignancies,including hepatocellular carcinoma(HCC).1 Despite encouraging effic...
关键词：HEPATOCELLULAR SIGNATURE inconsistent 
Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma(CHANCE001)被引量：57
《Signal Transduction and Targeted Therapy》2023年第3期1198-1207,共10页Hai-Dong Zhu Hai-Liang Li Ming-Sheng Huang Wei-Zhu Yang Guo-Wen Yin Bin-Yan Zhong Jun-Hui Sun Zhi-Cheng Jin Jian-Jian Chen Nai-Jian Ge Wen-Bin Ding Wen-Hui Li Jin-Hua Huang Wei Mu Shan-Zhi Gu Jia-Ping Li Hui Zhao Shu-Wei Wen Yan-Ming Lei Yu-Sheng Song Chun-Wang Yuan Wei-Dong Wang Ming Huang Wei Zhao Jian-Bing Wu Song Wang Xu Zhu Jian-Jun Han Wei-Xin Ren Zai-Ming Lu Wen-Ge Xing Yong Fan Hai-Lan Lin Zi-Shu Zhang Guo-Hui Xu Wen-Hao Hu Qiang Tu Hong-Ying Su Chuan-Sheng Zheng Yong Chen Xu-Ya Zhao Zhu-Ting Fang Qi Wang Jin-Wei Zhao Ai-Bing Xu Jian Xu Qing-Hua Wu Huan-Zhang Niu Jian Wang Feng Dai Dui-Ping Feng Qing-Dong Li Rong-Shu Shi Jia-Rui Li Guang Yang Hai-Bin Shi Jian-Song Ji Yu-E Liu Zheng Cai Po Yang Yang Zhao Xiao-Li Zhu Li-Gong Lu Gao-Jun Teng 
The study was supported by National Key Research and Development Program(2018YFA0704100,2018YFA0704104);National Natural Science Foundation of China(81827805,82130060);Jiangsu Provincial Special Program of Medical Science(BE2019750).The funding sources had no role in the writing of the report,or decision to submit the paper for publication.
There is considerable potential for integrating transarterial chemoembolization(TACE),programmed death-(ligand)1(PD-[L]1)inhibitors,and molecular targeted treatments(MTT)in hepatocellular carcinoma(HCC).It is necessar...
关键词：HEPATOCELLULAR TARGETED MATCHING 
O-GlcNAcylation of YTHDF2 promotes HBV-related hepatocellular carcinoma progression in an N^(6)-methyladenosine-dependent manner被引量：8
《Signal Transduction and Targeted Therapy》2023年第3期1208-1223,共16页Yang Yang Yu Yan Jiaxin Yin Ni Tang Kai Wang Luyi Huang Jie Hu Zhongqi Feng Qingzhu Gao Ailong Huang 
This work was supported by the China National Natural Science Foundation(grant no.82272975,U20A20392,82072286,82073251);the 111 Project(No.D20028);the Innovative and Entrepreneurial Team of Chongqing Talents Plan,the Natural Science Foundation Project of Chongqing(cstc2019jscx-dxwtBX0019,cstc2021jcyj-bsh0017);Chongqing Medical Scientific Research Project(Joint project of Chongqing Health Commission and Science and Technology Bureau,2023DBXM007);the Kuanren talents program of the second affiliated hospital of Chongqing Medical University,the Program for Youth Innovation in Future Medicine of Chongqing Medical University(W0036,W0101);the Science and Technology Research Program of Chongqing Municipal Education Commission(HZ2021006,KJZD-M202000401);the Postgraduate research and innovation projects of Chongqing Municipal Education Commission(CYB21174).
Hepatitis B virus(HBV)infection is a major risk factor for hepatocellular carcinoma(HCC),but its pathogenic mechanism remains to be explored.The RNA N^(6)-methyladenosine(m^(6)A)reader,YTH(YT521-B homology)domain 2(YT...
关键词：HEPATOCELLULAR markedly DF2 
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