MICROARRAY

作品数：440被引量：1533H指数：15
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  • 期刊=Genomics, Proteomics & Bioinformaticsx
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MSIsensor-RNA:Microsatellite Instability Detection for Bulk and Single-cell Gene Expression Data
《Genomics, Proteomics & Bioinformatics》2024年第3期85-90,共6页Peng Jia Xuanhao Yang Xiaofei Yang Tingjie Wang Yu Xu Kai Ye 
supported by the National Natural Science Foundation of China(Grant Nos.32070663,32125009,and 62172325);the National Key R&D Program of China(Grant No.2022YFC3400300);the Fundamental Research Funds for the Central Universities,China(Grant No.xzy012020012);the Natural Science Basic Research Program of Shaanxi,China(Grant No.2021GXLH-Z-098)to Kai Ye and Xaiofei Yang.
Microsatellite instability(MSI)is an indispensable biomarker in cancer immunotherapy.Currently,MSI scoring methods by high-throughput omics methods have gained popularity and demonstrated better performance than the g...
关键词：Microsatellite instability Gene expression Single-cell RNA-seq RNA-SEQ MICROARRAY 
JAX-CNV:A Whole-genome Sequencing-based Algorithm for Copy Number Detection at Clinical Grade Level
《Genomics, Proteomics & Bioinformatics》2022年第6期1197-1206,共10页Wan-Ping Lee Qihui Zhu Xiaofei Yang Silvia Liu Eliza Cerveira Mallory Ryan Adam Mil-Homens Lauren Bellfy Kai Ye Charles Lee Chengsheng Zhang 
supported in part by the operational funds from The First Affiliated Hospital of Xi’an Jiaotong University, China;supported by the National Institutes of Health, USA (Grant Nos. U24AG041689 and U54AG052427);supported by the National Natural Science Foundation of China (Grant Nos. 61702406 and 31671372);the National Science and Technology Major Project of China (Grant No. 2018ZX10302205);the National Key R&D Program of China (Grant Nos. 2018YFC0910400 and 2017YFC0907500);the General Financial Grant from the China Postdoctoral Science Foundation (Grant No. 2017M623178);supported in part by the Ewha Womans University Research, South Korea (Grant No. 2018-2019);supported in part by the Connecticut Bio-Innovative Fund, USA
We aimed to develop a whole-genome sequencing(WGS)-based copy number variant(CNV)calling algorithm with the potential of replacing chromosomal microarray assay(CMA)for clinical diagnosis.JAX-CNV is thus developed for ...
关键词：Copy number variant Chromosomal microarray assay Whole-genome sequencing JAX-CNV Genetic testing 
rePROBE:Workflow for Revised Probe Assignment and Updated Probe-set Annotation in Microarrays
《Genomics, Proteomics & Bioinformatics》2021年第6期1043-1049,共7页Frieder Hadlich Henry Reyer Michael Oster Nares Trakooljul Eduard Muráni Siriluck Ponsuksili Klaus Wimmers 
partly funded by the Leibniz Science Campus Phosphorus Research Rostock;funding from the European Research Area Network on Sustainable Animal Production (ERA-NET Sus An) as part of the PEGa Sus project (Grant No. 2817ERA02D);The Research Institute for Farm Animal Biology (FBN) provided own matched funding
Commercial and customized microarrays are valuable tools for the analysis of holistic expression patterns,but require the integration of the latest genomic information.This study provides a comprehensive workflow impl...
关键词：Mapping MICROARRAY Probe assignment Probe-set annotation Genomic database 
The Immunome of Colon Cancer: Functional In Silico Analysis of Antigenic Proteins Deduced from IgG Microarray Pro?ling被引量：2
《Genomics, Proteomics & Bioinformatics》2018年第1期73-84,共12页Johana A. Luna Coronell Khulan Sergelen Philipp Hofe Istvan Gyurjan Stefanie Brezina Peter Hettegger Gernot Leeb Karl Mach Andrea Gsur Andreas Weinhausel 
supported by the Life Science Krems Fund (Project No. 30);Jubilumsfonds of the Austrian National Bank (Project No. 15192);Vienna Science and Technology Fund (Project No LS11-026) of Austria
Characterization of the colon cancer immunome and its autoantibody signature from differentially-reactive antigens （DIRAGs） could provide insights into aberrant cellular mechanisms or enriched networks associated wi...
关键词：Autoantibody tumorbiomarker Cancer immunology Colorectal cancer IMMUNOMICS Protein microarray 
Comparative Gene Expression Analysis of Mouse and Human Cardiac Maturation被引量：3
《Genomics, Proteomics & Bioinformatics》2016年第4期207-215,共9页Hideki Uosaki Y-h Taguchi 
supported by Maryland Stem Cell Research Fund, USA (Grant No. 2015-MSCRFF-1765);supported by the grants from the Ministry of Education, Science (grant No. KAKENHI 26120528) and Chuo University joint research grant
Understanding how human cardiomyocytes mature is crucial to realizing stem cell-based heart regeneration, modeling adult heart diseases, and facilitating drug discovery. However, it is not feasible to analyze human sa...
关键词：Cardiac maturation Comparative gene expressionanalysis Microarray meta analysis Principal component analysis Feature selection 
Autoantigen Microarray for High-throughput Autoantibody Profiling in Systemic Lupus Erythematosus被引量：6
《Genomics, Proteomics & Bioinformatics》2015年第4期210-218,共9页Honglin Zhu Hui Luo Mei Yan Xiaoxia Zuo Quan-Zhen Li 
supported by the National Natural Science Foundation of China(Grant No.81270852)
Systemic lupus erythematosus （SLE） is a complex autoimmune disease characterized by the production of autoantibodies to a broad range of self-antigens. Profiling the autoantibody repertoire using array-based technol...
关键词：Systemic lupus erythemato-sus（SLE） Autoantibody profiling Proteomic microarray BIOMARKER High-throughput assay 
Competing Risks Data Analysis with High-dimensional Covariates:An Application in Bladder Cancer被引量：3
《Genomics, Proteomics & Bioinformatics》2015年第3期169-176,共8页Leili Tapak Massoud Saidijam Majid Sadeghifar Jalal Poorolajal Hossein Mahjub 
funded by the Vice Chancellor for Research and Technology of Hamadan University of Medical Sciences (grant No.9210173382)
Analysis of microarray data is associated with the methodological problems of high dimension and small sample size. Various methods have been used for variable selection in high- dimension and small sample size cases ...
关键词：MICROARRAY Elastic net Lasso Competing risks Subdistribution hazard Cause-specific hazard 
Identification of Differentially-expressed Genes in Intestinal Gastric Cancer by Microarray Analysis被引量：4
《Genomics, Proteomics & Bioinformatics》2014年第6期276-283,共8页Shizhu Zang Ruifang Guo Rui Xing Liang Zhang Wenmei Li Min Zhao Jingyuan Fang Fulian Hu Bin Kang Yonghong Ren Yonglong Zhuang Siqi Liu Rong Wang Xianghong Li Yingyan Yu Jing Cheng Youyong Lu 
supported by grants from the National Program on Key Basic Research Project of China (Grant No. 2004CB518708);the National High-Tech R&D Program of China (863 Program; Grant Nos. 2001AA233061, 2012AA02A203 and 2012AA02A504)
Gastric cancer（GC） is one of the most frequent malignant tumors. In order to systematically characterize the cellular and molecular mechanisms of intestinal GC development,in this study, we used 22 K oligonucleotide...
关键词：Gastric cancer development MICROARRAY Gene expression profile 
iBIG:An Integrative Network Tool for Supporting Human Disease Mechanism Studies
《Genomics, Proteomics & Bioinformatics》2013年第3期166-171,共6页Jiya Sun Yuyun Pan Xuemei Feng Huijuan Zhang Yong Duan Hongxing Lei 
supported by research grants from National Institute of Health to YD(Grant No. GM79383 and GM67168);Natural Science Foundation of China to HL(Grant No.30870474);Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry to HL
Understanding the mechanism of complex human diseases is a major scientitic challenge. Towards this end, we developed a web-based network tool named iBIG （stands for integrative BioloGy）, which incorporates a variet...
关键词：NETWORK Functional module Disease mechanism MICROARRAY Web server 
Whole miRNome-wide Differential Co-expression of MicroRNAs被引量：1
《Genomics, Proteomics & Bioinformatics》2012年第5期285-294,共10页Cord F.Stehler Andreas Keller Petra Leidinger Christina Backes Anoop Chandran Jerg Wischhusen Benjamin Meder Eckart Meese 
Financial support was granted by HOMFOR,Deutsche Forschungsgemeinschaft (DFG,LE 2783/1-1),and Hed-wig-Stalter Foundation
Co-regulation of genes has been extensively analyzed, however, rather limited knowledge is available on co-regulations within the miRNome. We investigated differential co-expression of microRNAs （miRNAs） based on mi...
关键词：CO-EXPRESSION MICROARRAY MicroRNA Network analysis 
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