HOMODIMER

作品数：9被引量：11H指数：2
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相关领域：生物学医药卫生更多>>
相关机构：四川大学更多>>
相关期刊：《Acta Pharmacologica Sinica》《Plant Communications》《Bioresources and Bioprocessing》《Acta Biochimica et Biophysica Sinica》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划更多>>
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Amphibian-derived peptide homodimer OA-GL17d promotes skin wound regeneration through the miR-663a/TGF-β1/Smad axis被引量：2
《Burns & Trauma》2022年第1期416-431,共16页Yue Zhang Ying Wang Lin Zeng Yixiang Liu Huiling Sun Shanshan Li Siyu Wang Longjun Shu Naixin Liu Saige Yin Junsong Wang Dan Ni Yutong Wu Ying Yang Li He Buliang Meng Xinwang Yang 
supported by grants from the National Natural Science Foundation of China(81760648,32060212 and 82160159);Yunnan Applied Basic Research Project Foundation(2019FB128);Project of Yunnan Applied Basic Research Project-Kunming Medical University Union Foundation(202101AY070001-006 and 2019FE001(-183));Program for Innovative Research Team in Ministry of Education of China(IRT17-R49);Science and Technology Leadership Talent Project in Yunnan China(2017HA010);Endocrine Clinical Medical Center of Yunnan Province(ZX2019-02-02);the Innovative Team of Precise Prevention and Treatment against Metabolic Diseases of Yunnan University,Scientific Research Fund Projects from the Department of Education of Yunnan Province(2021 J0205).
Background:Amphibian-derived peptides exhibit considerable potential in the discovery and development of new therapeutic interventions for clinically challenging chronic skin wounds.MicroRNAs(miRNAs)are also considere...
关键词：MicroRNA miR-663a Wound healing Peptide AMPHIBIAN Human keratinocytes OA-G17d Chronic wound Skin Transforming growth factor-β1 Smad 
Bis-isatin derivatives: design, synthesis, and biological activity evaluation as potent dimeric DJ-1 inhibitors被引量：3
《Acta Pharmacologica Sinica》2021年第7期1160-1170,共11页Xiao-bing Chen Hai-ying Zhu Kun Bao Li Jiang Hong Zhu Mei-dan Ying Qiao-jun He Bo Yang Rong Sheng Ji Cao 
This work was supported by grants from the National Natural Science Foundation of China(No.81773757 to MDY,No.81402951 to JC);the National Science Technology Major Project"Key New Drug Creation and Manufacturing Program/China(2018ZX09711002-003-008 to HZ);and the Zhejiang Provincial Natural Science Foundation(No.Y18H310005 to JC).
The PARK7 gene (encode DJ-1 protein) was first discovered as an oncogene and later found to be a causative gene for autosomal recessive early onset Parkinson’s disease. DJ-1 has been proposed as a potential therapeut...
关键词：DJ-1 inhibitor DM10 isatin derivatives HOMODIMER anticancer therapy apoptosis ferroptosis STK793590 
Crystal structures of NAC domains of human nascent polypeptide-associated complex (NAC) and its αNAC subunit被引量：1
《Protein & Cell》2010年第4期406-416,共11页Lanfeng Wang Wenchi Zhang Lu Wang Xuejun C.Zhang Xuemei Li Zihe Rao 
This work was supported by the National Natural Science Foundation of China(grant No.30730022);the National Basic Research Program(973 Program)(grant Nos.2006CB806503 and 2007CB914304);the National Programs for High Technology Research and Development Program(863 Program)(grant Nos.2006AA02A322 and 2006AA020502);the CAS(China)grant KSCX2-YW-R-05 to Z.R.
Nascent polypeptide associated complex(NAC)and its two isolated subunits,αNAC and βNAC,play important roles in nascent peptide targeting.We determined a 1.9Åresolution crystal structure of the interaction core of NA...
关键词：nascent polypeptide-associated complex αNAC homodimer βNAC crystal structure 
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