HOMODIMER

作品数：9被引量：11H指数：2
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Non-affinity platform for processing knob-into-hole bispecific antibody
《Bioresources and Bioprocessing》2024年第1期1447-1457,共11页Xiaoyang Wang Min Li Mengting Li Huoyan Hong Kai Gao Puya Zhao 
Bispecific antibodies hold significant potential as next-generation biotherapeutics owing to their ability to simultaneously bind to two targets.However,the development of bispecific antibodies as biotherapeutics has ...
关键词：Bispecific antibodies Non-protein A purification BYPRODUCTS HOMODIMER 
Arabidopsis ABCG14 forms a homodimeric transporter for multiple cytokinins and mediates long-distance transport of isopentenyladeninetype cytokinins被引量：1
《Plant Communications》2023年第2期179-192,共14页Jiangzhe Zhao Xiaojuan Deng Jiayun Qian Ting Liu Min Ju Juan Li Qin Yang Xiaoxian Zhu Weiqiang Li Chang-Jun Liu Zhigang Jin Kewei Zhang 
the National Natural Science Foundation of China(31470370 to K.Z.and 32100270 to J.Z.);the Natural Science Foundation of Zhejiang Province(LY22C020003 to J.Z.);C.-J.L.was supported by the DOE Office of Basic Energy Sciences,specifically through the Physical Biosciences Program of the Chemical Sciences,Geosciences and Biosciences Division,under contract DESC0012704.
Cytokinins(CKs),primarily trans-zeatin(tZ)and isopentenyladenine(iP)types,play critical roles in plant growth,development,and various stress responses.Long-distance transport of tZ-type CKs meidated by Arabidopsis ATP...
关键词：half-size ABC transporter HOMODIMER isopentenyladenine-type cytokinins long-distance transport circular transport 
Amphibian-derived peptide homodimer OA-GL17d promotes skin wound regeneration through the miR-663a/TGF-β1/Smad axis被引量：2
《Burns & Trauma》2022年第1期416-431,共16页Yue Zhang Ying Wang Lin Zeng Yixiang Liu Huiling Sun Shanshan Li Siyu Wang Longjun Shu Naixin Liu Saige Yin Junsong Wang Dan Ni Yutong Wu Ying Yang Li He Buliang Meng Xinwang Yang 
supported by grants from the National Natural Science Foundation of China(81760648,32060212 and 82160159);Yunnan Applied Basic Research Project Foundation(2019FB128);Project of Yunnan Applied Basic Research Project-Kunming Medical University Union Foundation(202101AY070001-006 and 2019FE001(-183));Program for Innovative Research Team in Ministry of Education of China(IRT17-R49);Science and Technology Leadership Talent Project in Yunnan China(2017HA010);Endocrine Clinical Medical Center of Yunnan Province(ZX2019-02-02);the Innovative Team of Precise Prevention and Treatment against Metabolic Diseases of Yunnan University,Scientific Research Fund Projects from the Department of Education of Yunnan Province(2021 J0205).
Background:Amphibian-derived peptides exhibit considerable potential in the discovery and development of new therapeutic interventions for clinically challenging chronic skin wounds.MicroRNAs(miRNAs)are also considere...
关键词：MicroRNA miR-663a Wound healing Peptide AMPHIBIAN Human keratinocytes OA-G17d Chronic wound Skin Transforming growth factor-β1 Smad 
Bis-isatin derivatives: design, synthesis, and biological activity evaluation as potent dimeric DJ-1 inhibitors被引量：3
《Acta Pharmacologica Sinica》2021年第7期1160-1170,共11页Xiao-bing Chen Hai-ying Zhu Kun Bao Li Jiang Hong Zhu Mei-dan Ying Qiao-jun He Bo Yang Rong Sheng Ji Cao 
This work was supported by grants from the National Natural Science Foundation of China(No.81773757 to MDY,No.81402951 to JC);the National Science Technology Major Project"Key New Drug Creation and Manufacturing Program/China(2018ZX09711002-003-008 to HZ);and the Zhejiang Provincial Natural Science Foundation(No.Y18H310005 to JC).
The PARK7 gene (encode DJ-1 protein) was first discovered as an oncogene and later found to be a causative gene for autosomal recessive early onset Parkinson’s disease. DJ-1 has been proposed as a potential therapeut...
关键词：DJ-1 inhibitor DM10 isatin derivatives HOMODIMER anticancer therapy apoptosis ferroptosis STK793590 
Structural characterizations of protonated homodimers of amino acids:Revealed by infrared multiple photon dissociation(IRMPD) spectroscopy and theoretical calculations被引量：3
《Chinese Chemical Letters》2018年第9期1333-1339,共7页Lifu Ma Juan Ren Ruxia Feng Kailin Zhang Xianglei Kong 
supported by the National Natural Science Foundation of China(Nos.21475065,21627801 and 11704280)
Infrared multiple photon dissociation （IRMPD） spectroscopic and theoretical studies of protonated homodimers of amino acids generated by electrospray ionization in the gas phase have been reviewed. Results show that...
关键词：Amino acid HOMODIMER IRMPD spectroscopy Proton affinity Charge-solvated Salt-bridged ESI mass spectrometry 
Structural studies on MRG701 chromodomain reveal a novel dimerization interface of MRG proteins in green plants被引量：1
《Protein & Cell》2016年第11期792-803,共12页Yanchao Liu Hong Wu Yu Yu Ying Huang 
MRG proteins are conserved during evolution in fungi, flies, mammals and plants, and they can exhibit diversified functions. The animal MRGs were found to form various complexes to activate gene expression. Plant MRGI...
关键词：MRG701 CHROMODOMAIN HOMODIMER 
Crystal structure of a novel non-Pfam protein PF2046 solved using low resolution B-factor sharpening and multi-crystal averaging methods
《Protein & Cell》2010年第5期453-458,共6页Jing Su Yang Li Neil Shaw Weihong Zhou Min Zhang Hao Xu Bi-Cheng Wang Zhi-Jie Liu 
This work was funded by the Ministry of Science and Technology of China(Grant Nos.2006AA02A316,2009DFB30310 and 2006CB910901);the National Natural Science Foundation of China(Grants Nos.30670427 and 30721003);the Ministry of Health of China(Grant No.2008ZX10404);CAS Research Grant(No.KSCX2-YW-R-127 and INFO-115-D01-2009).
Sometimes crystals cannot diffract X-rays beyond 3.0Åresolution due to the intrinsic flexibility associated with the protein.Low resolution diffraction data not only pose a challenge to structure determination,but als...
关键词：low resolution diffraction PF2046 Bfactor sharpening a homodimer of trimers 
Crystal structures of NAC domains of human nascent polypeptide-associated complex (NAC) and its αNAC subunit被引量：1
《Protein & Cell》2010年第4期406-416,共11页Lanfeng Wang Wenchi Zhang Lu Wang Xuejun C.Zhang Xuemei Li Zihe Rao 
This work was supported by the National Natural Science Foundation of China(grant No.30730022);the National Basic Research Program(973 Program)(grant Nos.2006CB806503 and 2007CB914304);the National Programs for High Technology Research and Development Program(863 Program)(grant Nos.2006AA02A322 and 2006AA020502);the CAS(China)grant KSCX2-YW-R-05 to Z.R.
Nascent polypeptide associated complex(NAC)and its two isolated subunits,αNAC and βNAC,play important roles in nascent peptide targeting.We determined a 1.9Åresolution crystal structure of the interaction core of NA...
关键词：nascent polypeptide-associated complex αNAC homodimer βNAC crystal structure 
Construction of fluorescence resonance energy transfer vectors and their application in study of structure and function of signal transducers and activators of transcription 1
《Acta Biochimica et Biophysica Sinica》2008年第11期934-942,共9页Fujun Han Yongfeng Luo Nanhai Ge Jun Xu 
Protein-protein interactions have been studied extensively by green fluorescent protein-based fluorescence resonance energy transfer （FRET）. The fluorescent proteins （FP） can be fused either to the N- or C-terminu...
关键词：signal transducers and activators of transcription 1 （STAT1） homodimer fluorescent proteinbased fluorescence resonance energy transfer （FRET） nucleocytoplasmic distribution 
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