CHROMODOMAIN

作品数：8被引量：11H指数：2
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相关领域：生物学医药卫生更多>>
相关作者：王伟许静张磊张理光王涛更多>>
相关机构：山西大学中国科学技术大学华中师范大学更多>>
相关期刊：《Pediatric Investigation》《中国生物化学与分子生物学报》《Acta Pharmacologica Sinica》《Protein & Cell》更多>>
相关基金：国家自然科学基金山西省自然科学基金山西省回国留学人员科研经费资助项目更多>>
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Chromodomain Y‐like(CDYL)inhibition ameliorates acute kidney injury in mice by regulating tubular pyroptosis
《Acta Pharmacologica Sinica》2024年第12期2598-2610,共13页Ting Xiang Ling-zhi Li Jin-xi Li Xin-yun Chen Fan Guo Jing Liu Yi-ting Wu Lin Lin Rui-han Xu Hui-ping Wang Liang Ma Ping Fu 
supported by the National Natural Science Foundation of China(82370737 to LM and 82100775 to LL);the 1.3.5 project for disciplines of excellence from West China Hospital of Sichuan University(ZYGD23015 to PF).
Acute kidney injury(AKI)is a common disease,but lacking effective drug treatments.Chromodomain Y‐like(CDYL)is a kind of chromodomain protein that has been implicated in transcription regulation of autosomal dominant ...
关键词：acute kidney injury tubular epithelial cell chromodomain Y‐like PYROPTOSIS fatty acid-binding protein 4 benzo[d]oxazol-2(3H)-one 
Long non-coding RNA DPP10-AS1 represses the proliferation and invasiveness of glioblastoma by regulating miR-24-3p/CHD5 signaling pathway被引量：3
《BIOCELL》2023年第12期2721-2733,共13页JIWEI SUN LIANG XU YESEN ZHANG HAORAN LI JIE FENG XUEFENG LU JUN DONG 
supported through the Natural Science Foundation of Jiangsu Province(No.BK20201172);the Key Project of the Jiangsu Health Commission(No.ZDB2020016);the Jiangsu Province Key Research and Development Program:Social Development Project(No.BE2021653).
This investigation aimed to unveil new prospective diagnosis-related biomarkers together with treatment targets against glioblastoma.Methods:The expression levels of long non-coding RNA(lncRNA)DPP10-AS1 were assessed ...
关键词：GLIOBLASTOMA lncRNA DPP10-AS1 miR-24-3p Chromodomain helicase DNA binding protein 5 
Variant analysis of the chromodomain helicase dNA-binding protein 7 in pediatric disorders of sex development
《Pediatric Investigation》2019年第1期31-38,共8页Beibei Zhang Yanning Song Wei Li Chunxiu Gong 
Importance:This study investigated the role of the chromodomain helicase DNA-binding protein 7(CHD7)in disorders of sex development(DSD).Objective:We aimed to present the potential pathogenicity of CHD7 variants in pe...
关键词：Disorders of sex development CHD7 variants Genital abnormalities 
嗜热四膜虫异染色质蛋白Tcd1磷酸化位点的突变分析
《中国生物化学与分子生物学报》2018年第5期502-509,共8页凌晨 许静 王伟 
国家自然科学基金项目(No.31471999;No.31572253);山西省回国留学人员科研资助项目(No.2015-008)资助~~
四膜虫异染色质蛋白Tcd1在有性生殖时期特异表达,在大核基因组重排以及修复过程中发挥作用。磷酸化蛋白质组学分析表明,Tcd1存在3个磷酸化位点:S301,S303和S535。然而,Tcd1磷酸化修饰与其功能的关系并不清楚。本研究对TCD1基因的3个磷...
关键词：嗜热四膜虫 四膜虫chromodomain蛋白1(Tcd1) 磷酸化 突变 细胞定位 
Structural studies on MRG701 chromodomain reveal a novel dimerization interface of MRG proteins in green plants被引量：1
《Protein & Cell》2016年第11期792-803,共12页Yanchao Liu Hong Wu Yu Yu Ying Huang 
MRG proteins are conserved during evolution in fungi, flies, mammals and plants, and they can exhibit diversified functions. The animal MRGs were found to form various complexes to activate gene expression. Plant MRGI...
关键词：MRG701 CHROMODOMAIN HOMODIMER 
嗜热四膜虫Tcd1蛋白功能结构域的突变分析被引量：4
《中国生物化学与分子生物学报》2016年第5期528-535,共8页袁亚静 许静 王伟 
国家自然科学基金(No.31471999,No.315672253);山西省国际合作计划项目(No.2015081032);山西省自然科学基金(No.2015011178)资助
有性生殖过程特异表达的Tcd1在四膜虫大核基因组重排和修复中起到重要调节作用,Tcd1含有进化中保守的chromodomain(CD)结构域以及chromo shadow domain(CSD)结构域,然而不同结构域的具体功能并不清楚。本研究首先鉴定了TCD1基因仅含有1...
关键词：嗜热四膜虫 CHROMODOMAIN chromo SHADOW domain 突变 细胞定位 
Chromodomain-helicase-DNA binding protein 5, 7 and pronecrotic mixed lineage kinase domain-like protein serve as potential prognostic biomarkers in patients with resected pancreatic adenocarcinomas被引量：2
《World Journal of Gastrointestinal Oncology》2016年第4期358-365,共8页Crystal S Seldon Lauren E Colbert William A Hall Sarah B Fisher David S Yu Jerome C Landry 
Supported by The National Center for Advancing Translational Sciences of the National Institutes of Health under award numbers ULl TR000454 previously awarded to Dr.Colbert and Dr.Fisher and TLlT R000456 to Dr.Colbert;Pancreatic Cancer Action Network(Pan-CAN)&sol American Association for Cancer Research(AACR)award 16982;Department of Defense(DOD)/Peer Reviewed Cancer Research Program(PRCRP)award CA110535;Georgia Cancer Coalition award 11072,all to Dr.Yu
Pancreatic cancer is one of the deadliest cancers with a very poor prognosis. Recently, there has been a significant increase in research directed towards identifying potential biomarkers that can be used to diagnose ...
关键词：Chromodomain-helicase-DNA BINDING PROTEIN 5 Chromodomain-helicase-DNA BINDING PROTEIN 7 Mixed lineage kinase domain-like PROTEIN Pancreatic adenocarcinoma Biomarker 
Chromodomain蛋白在表观遗传调控中的功能被引量：1
《中国生物化学与分子生物学报》2016年第4期359-364,共6页袁亚静 许静 王伟 
国家自然科学基金项目(No.31471999;No.315672253);山西省国际合作计划项目(No.2015081032);山西省自然科学基金(No.2015011178)资助~~
克罗莫结构域(chromatin organization modifier domain,chromodomain)是与染色质结构相关的进化上保守的蛋白质模体。Chromodomain中芳香族氨基酸残基组成保守的疏水"box"结构与"组蛋白密码"中的二甲基或三甲基修饰的H3K9和H3K27结合,...
关键词：克罗莫结构域 染色质 组蛋白甲基化 
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