supported by grants from the National Natural Science Foundation of China(No.82170342);Shanghai Engineering Research Center of Interventional Medicine(No.19DZ2250300);National Key R&D Program of China(No.2021YFA1201300);Chinese Academy of Medical Sciences(Nos.2019-I2M-5-060 and 2020-JKCS-0154020);the Fellowship of the China National Postdoctoral Program for Innovative Talents(No.BX20220094);China Postdoctoral Science Foundation(No.2022M710776);Shanghai Shenkang Hospital Development Center(No.SHDC2020CR3023B).
Background:Hypothermia therapy has been suggested to attenuate myocardial necrosis;however,the clinical implementation as a valid therapeutic strategy has failed,and new approaches are needed to translate into clinica...
supported by a grant from the Major Engineering Projects from Tianjin Science and Technology Committee(No.16ZXMJSY00150)。
Background:Various experimental and clinical studies have reported on coronary microcirculatory dysfunction("no-reflow"phenomenon).Nevertheless,pathogenesis and effective treatment are yet to be fully elucidated.This ...
The study was supported by grants from the Shanghai Science and Technology Foundation (No. 05DZ19503) and the National Natural Science Foundation of China (No. 30900589) Conflict of interest: None
Background No randomized trial has been performed to compare the efficacy of an intracoronary bolus of tirofiban versus urokinase during primary percutaneous coronary intervention (PCI).We investigated whether the e...
ST-segment elevation myocardial infarction (STEMI) is usually caused by acute occlusion of an infarct-related coronary artery (IRA), resulting from rupture or erosion of an atherosclerotic plaque and subsequent pl...
Background Transplantation of adult bone marrow-derived mesenchymal stem cells (MSCs) has been proposed as a strategy for cardiac repair following myocardial damage. However cell transplantation strategies to replac...
Background No-reflow phenomenon during percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI) is a predictive factor of continuous myocardial ischemia, ventricular remodeling and cardiac dy...
Background Myocardial perfusion associates with clinical syndromes and prognosis. Adenosine could improve myocardial perfusion of acute myocardial infarction within 6 hours, but few data are available on late perfusio...
Background Early local platelet activation after coronary intervention identifies patients at increased risk of acute stent thrombosis (AST). However, early changes in platelet activation in coronary circulation fol...
This project was supported by a grant from the Natural Science Foundation of Hebei Province (No. C0303020).
Background Many basic and clinical studies have proved that anisodamine can produce significant effect on relieving microvascular spasm, improving and dredging the coronary microcirculation. It may be beneficial to th...
Objective To observe the immediate angiographic and intravascular ultrasound (IVUS) results and their effects on one month clinical outcomes in forty one patients who submitted to coronary stent deployment with IVUS...