IMRECOXIB

作品数：3被引量：20H指数：2
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相关领域：医药卫生更多>>
相关作者：张玉峰钟大放曹建刚徐海燕孔璋更多>>
相关机构：沈阳药科大学天津医科大学河北医科大学更多>>
相关期刊：《Acta Pharmacologica Sinica》更多>>
相关基金：国家自然科学基金国家高技术研究发展计划更多>>
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Formation of 4'-carboxyl acid metabolite of imrecoxib by rat liver microsomes被引量：4
《Acta Pharmacologica Sinica》2006年第4期506-512,共7页Hai-yan XU Peng ZHANG Ai-shen GONG Yu-ming SUN Feng-ming CHU Zong-m GUO Da-fang ZHONG 
Project supported by the National High Technology Research and Development Program of China(№2003AA2Z347C).
Aim： Imrecoxib is a novel and moderately selective COX-2 inhibitor. The aim of the present in vitro investigation was to study the formation of the major metabolite 4^1-carboxylic acid imrecoxib （M2） and identify t...
关键词：IMRECOXIB cytochrome P450 METABOLISM liver microsomes RATS 
Role of rat liver cytochrome P450 3A and 2D in metabolism of imrecoxib被引量：2
《Acta Pharmacologica Sinica》2006年第3期372-380,共9页Hai-yan XU Zhi-yong XIE Peng ZHANG Jin SUN Feng-ming cno Zong-ru GUO Da-fang ZHONG 
Project supported by a grant from the "863"program of China(№2003AA2Z347C).
Aim： To investigate the in vitro metabolism of imrecoxib in rat liver microsomes and to identify the cytochrome P450 （CYP） forms involved in its metabolism. Methods： Liver microsomes of Wistar rats were prepared u...
关键词：IMRECOXIB cytochrome P450 METABOLISM liver microsomes 
Imrecoxib: a novel and selective cyclooxygenase 2 inhibitor with anti-inflammatory effect被引量：18
《Acta Pharmacologica Sinica》2004年第7期927-931,共5页Xiao-hongCHEN Jin-yeBAI FangSHEN Ai-pingBAI Zong-ruGUO Gui-fangCHENG 
Project supported by National Natural Science Foundation of China (No 20072057).
AIM: To investigate the inhibitory effect of imrecoxib, a synthetic compoundof completely new structure, on cyclooxygenase 1 (COX-1) and 2 (COX-2) and its anti-inflammatoryeffect in vivo. METHODS: The inhibitory effec...
关键词：IMRECOXIB cyclooxygenase 1 cyclooxygenase 2 cyclooxygenase inhibitors INFLAMMATION 
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