BENZODIAZEPINE

作品数:42被引量:26H指数:3
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相关领域:医药卫生更多>>
相关作者:秦珅李庆云蒋为群王彦林莹妮更多>>
相关机构:台湾大学兰斯大学上海交通大学医学院附属瑞金医院河北师范大学更多>>
相关期刊:《Journal of Pharmaceutical Analysis》《Advances in Bioscience and Biotechnology》《Journal of Behavioral and Brain Science》《Journal of Biosciences and Medicines》更多>>
相关基金:国家自然科学基金国家重点基础研究发展计划更多>>
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  • 期刊=Chemical Research in Chinese Universitiesx
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Design,Synthesis and Biological Evaluation of Pyrrolo[2,1-c][1,4]benzodiazepine-3,11-dione Derivatives as Novel Neuroprotective Agents
《Chemical Research in Chinese Universities》2021年第3期647-654,共8页QUAN Jishun ZHANG Dongping ZHANG Zhuo WANG Jian MA Chao CHENG Maosheng 
This work was supported by the National Natural Science Foundation of China(No.21977074);the Science and Technology Projects from the Educational Department of Liaoning Province,China(No.2019LQN02).
A series of pyrrolo[2,1-c][1,4]benzodiazepine-3,11-dione derivatives was designed and synthesized,and their neuroprotective activity against SH-SY5Y cell injury induced by N-methyl-D-aspartic acid(NMDA)was evaluated.A...
关键词:Neuroprotective activity Ca^(2+)influx Western blotting NR2B-NMDA receptor Molecular docking 
Studies on the Activities of Electrophilic Sites on Benzene Ring of 4-Substituted Anilines and Their Acyl Compounds with Multiphilicity Descriptor被引量:5
《Chemical Research in Chinese Universities》2017年第5期773-778,共6页SHEN Xizhou HE Huajun YANG Bowen ZHAO Zhigang SHAO Kaiyuan HU Wenxiang 
In this paper, the activities of electrophilic sites on benzene ring of 4-substituted anilines and their acyl compounds were studied with the quantitative indicator of multiphilicity descriptor. Four substituents were...
关键词:Quantum chemical calculation Electrophilic site Multiphilicity descriptor BENZODIAZEPINE Electrophilic substitution reaction 
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