funded by the National Natural Science Foundation of China(No.U2002218,32270170 and 81902070);the Fund of Hunan University(521119400156);the Science and Technology Innovation Program of Hunan Province(2024RC1028).
Histone mimicry(HM)refers to the presence of short linear motifs in viral proteins that mimic critical regions of host histone proteins.These motifs have the potential to interfere with host cell epigenome and counter...
supported by the National Natural Science Foundation of China(31830045,32025005,32100429)。
Lariat RNA is concomitantly produced by excised intron during RNA splicing,which is usually debranched by DBR1,an RNA debranching enzyme.However,increasing evidence showed that some lariat RNA could escape debranching...
funded by the Wellcome Trust and the Royal Society(Grant Number 222623/Z/21/Z);KDJ is a Post-Doctoral Fellow supported by an MRC Programme Grant(MR/T029765/1)awarded to Professor Graham Anderson.
The thymus is the primary production site for a functional and self-tolerant T-cell repertoire.The establishment of immune tolerance is mediated by the generation and presentation of tissue-restricted self-antigens(TR...
Supported by CAMS Innovation Fund for Medical Sciences,No.2020-I2M-C&T-A-004;National High Level Hospital Clinical Research Funding,No.2022-PUMCH-A-210,No.2022-PUMCH-B-041,and No.2022-PUMCH-C-025;and National Key R&D Program of China,No.2020YFE0201600.
Wound repair is a complex challenge for both clinical practitioners and researchers.Conventional approaches for wound repair have several limitations.Stem cell-based therapy has emerged as a novel strategy to address ...
supported by a 2-Year Research Grant of Pusan National University(to SIA).
Neurological disorders including neurodegenerative diseases,brain tumors,and stroke are the second leading cause of death and the greatest cause of disability worldwide.However,it remains challenging to achieve effect...
funded by the National Natural Science Foundation of China(Grant Nos.:82004081 and 52073145);the National Natural Science Foundation of Nanjing University of Chinese Medicine,China(Grant No.:NZY82004081).
The treatment of non-small cell lung cancer(NSCLC)remains a challenge due to tumor evolution during anti-angiogenesis therapies,in which the mechanism of vascular mimicry(VM)is believed to result in ineffective treatm...
Pathogens have developed an extensive array of proteins during the co-evolutionary arms race with their hosts.This is particularly true for Phytophthora,a genus that causes significant damage to agriculture and forest...
supported in part by National Key R&D Plan(2022YFB3102901)
Recent advances in deep learning have led to disruptive breakthroughs in artificial intelligence(AI),fueling the jump in ChatGPT-like large language models(LLMs).As with any emerging technology,it is a two-sided coin,...
Organoseleniums are a class of compounds attracting attention across the globe owing to their Glutathione peroxidase(GPx)mimicry,which confers on them a strong antioxidant activity.Diphenyl diselenide(DPDS)is an Organ...
Background:Mistletoes are the most successful group of obligatory hemi-parasitic flowering plants that attach to the host via haustorium for obtaining water and minerals.This review aims to assess the current knowledg...