In a recent study published in Cell,Baek et al.used cryoelectron microscopy to capture transitional conformations of Cand1,a regulator of SCF ubiquitin ligases,depicting its utilization of a“rock-and-roll”mechanism ...
Mutations of the CUL4B ubiquitin ligase gene are causally linked to syndromic X-linked mental retardation (XLMR). However, the pathogenic role of CUL4B mutations in neuronal and developmental defects is not understo...