云南高校图书馆联盟文献共享服务平台- CULLIN

CULLIN: 作品数：49被引量：111H指数：7; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：孙毅俞卿曹璐李圣陶王大燕更多>>; 相关机构：浙江大学山东大学浙江大学医学院附属儿童医院上海交通大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划卫生部科学研究基金更多>>

A Cullin 5-based complex serves as an essential modulator of ORF9b stability in SARS-CoV-2 replication: 《Signal Transduction and Targeted Therapy》2024年第7期3112-3129,共18页Yuzheng Zhou Zongpeng Chen Sijie Liu Sixu Liu Yujie Liao Ashuai Du Zijun Dong Yongxing Zhang Xuan Chen Siyi Tao Xin Wu Aroona Razzaq Gang Xu De-an Tan Shanni Li Youwen Deng Jian Peng Shuyan Dai Xu Deng Xianwen Zhang Taijiao Jiang Zheng Zhang Gong Cheng Jincun Zhao Zanxian Xia; supported by the National Key Research and Development Program of China(2021YFC2300103);the National Natural Science Foundation of China(U21A20384 and 82072293);the Natural Science Foundation of Hunan Province,China(2022JJ30692);the China Postdoctoral Science Foundation(2023M731520).; The ORF9b protein,derived from the nucleocapsid’s open-reading frame in both SARS-CoV and SARS-CoV-2,serves as an accessory protein crucial for viral immune evasion by inhibiting the innate immune response.Despite it...; 关键词：STABILITY MODULATOR offering

How “rock-and-roll” solved the cullin supply chain problem: 《Cell Research》2023年第10期741-742,共2页Sheena Faye Garcia Michele Pagano; In a recent study published in Cell,Baek et al.used cryoelectron microscopy to capture transitional conformations of Cand1,a regulator of SCF ubiquitin ligases,depicting its utilization of a“rock-and-roll”mechanism ...; 关键词：ROCK CONFORMATION CATALYTIC

Cullin 4B-RING E3 ligase complex in immune cell differentiation and function: 《Cellular & Molecular Immunology》2023年第10期1254-1256,共3页Yu Song Shiqi Jin Gongping Sun Yaoqin Gong; supported by the National Natural Science Foundation of China(82171851)to YG.; CUL4B,which encodes the scaffold protein in the CRL4B complex,is a commonly mutated gene in X-linked intellectual disability[10,11].In addition to intellectual disability,patients with CUL4B mutations present with an ...; 关键词：GSK3Β ELEVATED STIMULATION

微小RNA-455靶向调控泛素连接酶Cullin3活化核转录因子-κB在炎性神经痛中的作用及其机制: 《中华实验外科杂志》2023年第9期1804-1807,共4页赵伟周思怡徐大伟; 江苏省"333工程"项目(BRA2020204);江苏省六大人才高峰高层次人才(WSW-277)。; 目的探讨微小RNA(miRNA,miR)-455靶向调控泛素连接酶Cullin3(CUL3)活化核转录因子-κB(NF-κB)在炎性神经痛中的作用及其机制。方法培养施万细胞(SCs),过表达miR-455、CUL3和反义miR-455以及慢病毒CUL3-短发卡RNA(shRNA)质粒沉默CUL3表...; 关键词：神经痛施万细胞微小RNA 泛素连接酶Cullin 3 核转录因子-ΚB

Arctigenin impairs UBC12 enzyme activity and cullin neddylation to attenuate cancer cells被引量：1: 《Acta Pharmacologica Sinica》2023年第3期661-669,共9页Yi-fan Chen Run-zhi Liu Wen-wen Ying Yue-ning Yang Sen-feng Xiang Xue-jing Shao Ji Cao Yan-qi Zhang Bo Yang Qiao-jun He Mei-dan Ying; the Zhejiang Provincial Natural Science Foundation of China(No.LD21H310001);the Fundamental Research Funds for the Central Universities(No.2021XZZX037);the Zhejiang Science and Technology Program of Traditional Chinese Medicine(No.2022zQ064);Westlake Laboratory(Westlake Laboratory of Life Sciences and Biomedicine);Leading Talent of"Ten Thousand Plan"-National High-Level Talents Special Support Plan.; Neddylation is a type of posttranslational protein modification that has been observed to be overactivated in various cancers.UBC12 is one of two key E2 enzymes in the neddylation pathway.Reports indicate that UBC12 d...; 关键词：UBC12 ARCTIGENIN NEDDYLATION cancer therapy PDCD4

Cullin家族通过UPS途径响应小麦生长发育及非生物胁迫进程被引量：1: 《分子植物育种》2022年第21期7071-7081,共11页赵梦伊魏春茹范润侨杨一鸣杨近炳孟妍君赵伟全于秀梅; 河北省自然科学基金项目(C2020204050);河北省高等学校科学技术研究项目(ZD2019086);河北省研究生创新项目(CXZZBS2021046)共同资助。; Cullin作为泛素-蛋白酶体系统(ubiquitin-proteasome system,UPS)中多亚基E3泛素连接酶的骨架蛋白,与泛素结合酶E2相互作用,将泛素分子连接到待降解底物上,使底物携带泛素链标记,进而被26S蛋白酶体识别并降解。Cullin家族成员在植物体...; 关键词：小麦Cullin家族基因组鉴定进化分析染色体分布蛋白互作

Lentivirus-mediated short hairpin RNA interference of CENPK inhibits growth of colorectal cancer cells with overexpression of Cullin 4A被引量：2: 《World Journal of Gastroenterology》2022年第37期5420-5443,共24页Xian Li Yi-Ru Han Xuefeng Xuefeng Yong-Xiang Ma Guo-Sheng Xing Zhi-Wen Yang Zhen Zhang Lin Shi Xin-Lin Wu; the National Natural Science Foundation of China,No.81860416 and No.22168028;Inner Mongolia Autonomous Region Grassland Talent Innovation Talent Team Fund,No.2019;Inner Mongolia Natural Science Fund,No.2021MS02005.; BACKGROUND Colorectal cancer(CRC)is one of the most common malignant tumors worldwide.The identification of novel diagnostic and prognostic biomarkers for CRC is a key research imperative.Immunohistochemical analysis ...; 关键词：Colorectal cancer Centromere protein K Bioinformatics analysis Lentivirus-mediated short hairpin RNA interference Cullin 4A

Targeting the COP9 signalosome for cancer therapy被引量：2: 《Cancer Biology & Medicine》2022年第5期573-590,共18页Wenqi Du Ruicheng Zhang Bilal Muhammad Dongsheng Pei; This work was supported by the National Natural Science Foundation of China(Grant No.81872080);Jiangsu Provincial Medical Talent(Grant No.ZDRCA 2016055);the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD).; The COP9 signalosome(CSN)is a highly conserved protein complex composed of 8 subunits(CSN1 to CSN8).The individual subunits of the CSN play essential roles in cell proliferation,tumorigenesis,cell cycle regulation,DNA...; 关键词：COP9 signalosome UBIQUITIN cullin-RING ligases cell proliferation TUMORIGENESIS

Overexpressed NEDD8 as a potential therapeutic target in esophageal squamous cell carcinoma: 《Cancer Biology & Medicine》2022年第4期504-517,共14页Jingrong Xian Shiwen Wang Yanyu Jiang Lihui Li Lili Cai Ping Chen Yue Liu Xiaofei Zeng Guoan Chen Chen Ding Robert MHoffman Lijun Jia Hu Zhao Yanmei Zhang; This work was supported by grants from the National Natural Science Foundation of China(Grant Nos.81602072,81902380,81820108022,and 81625018);Innovation Program of Shanghai Municipal Education Commission(Grant No.2019-01-07-00-10-E00056);Program of Shanghai Academic/Technology Research Leader(Grant No.18XD1403800);National High Technology Research and Development Program of China(Grant No.2015AA021107-019);Scientific Research Project of Shanghai Science and Technology Commission(Grant No.18411960600);Shanghai Technological Innovation Action Projects(Grant No.18411950800);Shanghai‘Rising Stars of Medical Talent’Youth Development Program,Outstanding Youth Medical Talents,2018;the Shanghai Sailing Program(Grant No.17YF1405000).; Objective:The hyperactivated neddylation pathway plays an important role in tumorigenesis and is emerging as a promising anticancer target.We aimed to study whether NEDD8(neural precursor cell expressed,developmentall...; 关键词：NEDD8 esophageal squamous cell carcinoma cullin-RING E3 ubiquitin ligases APOPTOSIS anticancer target

SAG E3泛素连接酶:生物学功能、作用机理及其相关的人类疾病: 《中国细胞生物学学报》2022年第4期648-662,共15页俞卿孙毅; 国家重点研发计划(批准号:2021YFA1101000,2016YFA0501800,项目负责人:孙毅);国家自然科学基金(批准号:82102749,项目负责人:俞卿);浙江省自然科学基金(批准号:LD22H300003,项目负责人:孙毅)资助的课题。; 凋亡敏感基因蛋白(Sensitive to Apoptosis Gene,SAG)是一种结构上进化保守的锌环指蛋白(zinc RING finger protein),1997年由该文笔者的实验室首次克隆,并于1999年发表。大量研究先后证实SAG不仅是一个具有抗氧化能力、可抑制金属离子...; 关键词：SAG Cullin-5 E3泛素连接酶泛素化拟素化抗肿瘤

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