CELASTROL

作品数：55被引量：194H指数：9
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相关作者：于小龙戴闽周鑫付长林王强更多>>
相关机构：南昌大学第一附属医院中山大学南京师范大学广州医科大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划高等学校学科创新引智计划广东省自然科学基金更多>>
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  • 期刊=Chinese Journal of Natural Medicinesx
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Activation of NRF2 by celastrol increases antioxidant functions and prevents the progression of osteoarthritis in mice被引量：2
《Chinese Journal of Natural Medicines》2024年第2期137-145,共9页LIU Mingming GUO Jiatian ZHAO Jing LI Hongye FENG Xiaoxiao LIU Haojun ZHANG Hao JIA Xuejun WEI Rushuai LI Fang CHEN Chong HOU Mingzhuang LV Nanning XU Haiyan 
supported by the Key Research and Development Plan of Jiangsu Province(Social Development Project,No.BE2021679);the National Natural Science Foundation Project(No.82171762).
Excessive oxidative stress impairs cartilage matrix metabolism balance,significantly contributing to osteoarthritis(OA)development.Celastrol(CSL),a drug derived from Tripterygium wilfordii,has recognized applications ...
关键词：OSTEOARTHRITIS CELASTROL Articular cartilage Extracellular matrix NRF2 
Identification of a cytochrome P450 from Tripterygium hypoglaucum(Levl.)Hutch that catalyzes polpunonic acid formation in celastrol biosynthesis被引量：2
《Chinese Journal of Natural Medicines》2022年第9期691-700,共10页CHEN Xiao-Chao LU Yun LIU Yuan ZHOU Jia-Wei ZHANG Yi-Feng GAO Hai-Yun LIDan GAO Wei 
supported by the National Key R&D Program of China(No.2020YFA0908000);the National Natural Science Foundation of China(Nos.81773830 and 81973418);the Key Project at Central Government Level:the ability establishment of sustainable use for valuable Chinese medicine resources(No.2060302-1806-03),and the National Program for Special Support of Eminent Professionals.
Tripterygium hypoglaucum(Levl.)Hutch,a traditional Chinese medicinal herb with a long history of use,is widely distributed in China.One of its main active components,celastrol,has great potential to be developed into ...
关键词：Tripterygium hypoglaucum Cytochrome P450 Polpunonic acid CELASTROL BIOSYNTHESIS 
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