CELASTROL

作品数：55被引量：194H指数：9
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相关领域：医药卫生更多>>
相关作者：于小龙戴闽周鑫付长林王强更多>>
相关机构：南昌大学第一附属医院中山大学南京师范大学广州医科大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划高等学校学科创新引智计划广东省自然科学基金更多>>
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Ferroptosis inhibitors reduce celastrol toxicity and preserve its insulin sensitizing effects in insulin resistant HepG2 cells
《Journal of Integrative Medicine》2024年第3期286-294,共9页Jia-jia Liu Xue Zhang Bang-lan Cai Man-man Qi Yong-bin Chi Bin Peng Deng-hai Zhang 
Objective:Research has shown that celastrol can effectively treat a variety of diseases,yet when passing a certain dosage threshold,celastrol becomes toxic,causing complications such as liver and kidney damage and ery...
关键词：CELASTROL Insulin resistance Ferroptosis N-ACETYLCYSTEINE Palmitic acid Molecular docking 
Celastrol targets IRAKs to block Toll-like receptor 4-mediated nuclear factor-κB activation被引量：9
《Journal of Integrative Medicine》2016年第3期203-208,共6页Yu-fan Shen Xue Zhang Ying Wang Fan-fan Cao Georges Uzan Bin Peng Deng-hai Zhang 
the Shanghai Gongli Hospital Youth Project (No. 2014GLQN16 for YS and No. 2012GLQN09 for XZ);the Shanghai Pudong District Science and Technology Innovation Project (No. PKJ2013-Y03 for YW);the Shanghai Pudong Youth Talent Project in Medicine (No. PWRq2013-11 for FC);the Shanghai Yang Fan Project (No. 15YF1410800 for FC);the International Science & Technology Cooperation Project of China (Grant 2011DFB30010 for GU);the National Natural Science Foundation of China (No. 81102349 for BP and No. 81400793 for YW);the Shanghai Excellent Academic Leader in Medicine (No. XBR2011054 for DZ);the Shanghai Traditional Chinese Medicine Content Construction Innovation Project (No. ZY3-CCCX-3-7001 for DZ)
OBJECTIVE： Celastrol has been established as a nuclear factor-κB（NF-κB） activation inhibitor; however, the exact mechanism behind this action is still unknown. Using text-mining technology, the authors predicted ...
关键词：CELASTROL interleukin-1 receptor-associated kinases nuclear factor-kappa B Toll-like receptor 4 HEPATOCYTES 
Pristimerin enhances recombinant adeno-associated virus vector-mediated transgene expression in human cell lines in vitro and murine hepatocytes in vivo被引量：8
《Journal of Integrative Medicine》2014年第1期20-34,共15页Li-na Wang Yuan Wang Yuan Lu Zi-fei Yin Yuan-hui Zhang George V.Aslanidi Arun Srivastava Chang-quan Ling Chen Ling 
supported in part by the Alex's Lemonade Foundation,and Bankhead-Coley Cancer Research Program,Florida Department of Health(to CL), Public Health Service grants R01 HL-097088 and R21 EB-015684 from the National Institutes of Health,and an institutional grant from the Children's Miracle Network (to AS,CL and GA);supported in part by the state-sponsored program for Graduate Students from China Scholarship Council,Government of China, and the National Natural Science Foundation of China (No.30730114)
OBJECTIVE： In the present study, we systemically evaluated the ability of two bioactive compounds from traditional Chinese medicine, celastrol and pristimerin, to enhance recombinant adeno-associated virus （rAAV） s...
关键词：CELASTROL pristimerin adeno-associated viral vector proteosomal inhibitor gene therapy 
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