the National Natural Science Foundation of China (Nos.81672724, 8187191 & and 81472573);the Supporting Programs of Shanghai Science and Technology Innovation Action Plan (No.18431902900);the Grant from the State Key Laboratory of Oncogenes and Related Genes (No.91-17-17);the Shanghai Municipal Commission of Health and Family Planning (No.201540213).
Colorectal cancer (CRC) is a common malignant tumor in the digestive tract, and 30%—85% of CRCs express epidermal growth factor receptors (EGFRs). Recently, treatments using cetuximab, also named C225, an anti-EGFR m...