ECTODOMAIN

作品数：9被引量：17H指数：2
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相关领域：医药卫生生物学更多>>
相关作者：汪炬更多>>
相关机构：暨南大学更多>>
相关期刊：《Theoretical & Applied Mechanics Letters》《Frontiers in Biology》《Virologica Sinica》《Chinese Medical Journal》更多>>
相关基金：国家自然科学基金国家高技术研究发展计划湖北省卫生厅科研基金更多>>
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Improving Cross-Protection against Influenza Virus Using Recombinant Vaccinia Vaccine Expressing NP and M2 Ectodomain Tandem Repeats被引量：2
《Virologica Sinica》2019年第5期583-591,共9页Wenling Wang Baoying Huang Xiuping Wang Wenjie Tan Li Ruan 
supported by grant from the National Key Plan for Scientific Research and Development of China (2016YFC1200200)
Conventional influenza vaccines need to be designed and manufactured yearly.However,they occasionally provide poor protection owing to antigenic mismatch.Hence,there is an urgent need to develop universal vaccines aga...
关键词：Influenza A virus(IAV) CROSS-PROTECTION Recombinant vaccinia virus Conserved antigen 
Growth suppression of colorectal cancer expressing S492R EGFR by monoclonal antibody CH12被引量：1
《Frontiers of Medicine》2019年第1期83-93,共11页Qiongna Dong Bizhi Shi Min Zhou Huiping Gao Xiaoying Luo Zonghai Li Hua Jiang 
the National Natural Science Foundation of China (Nos.81672724, 8187191 & and 81472573);the Supporting Programs of Shanghai Science and Technology Innovation Action Plan (No.18431902900);the Grant from the State Key Laboratory of Oncogenes and Related Genes (No.91-17-17);the Shanghai Municipal Commission of Health and Family Planning (No.201540213).
Colorectal cancer (CRC) is a common malignant tumor in the digestive tract, and 30%—85% of CRCs express epidermal growth factor receptors (EGFRs). Recently, treatments using cetuximab, also named C225, an anti-EGFR m...
关键词：S492R EGFR ECTODOMAIN mutation COLORECTAL cancer MAB CH12 immunnotherapy 
Quantification of the stiffness and strength of cadherin ectodomain binding with different ions被引量：3
《Theoretical & Applied Mechanics Letters》2014年第3期55-60,共6页Zhiyang Xu Dechang Li Baohua Ji 
supported by the National Natural Science Foundation of China(11025208,11221202,11372042,and 11202026);the Excellent Young Scholars Research Fund of Beijing Institute of Technology
The stiffness and strength of extracellular （EC） region of cadherin are proposed to be two important mechanical properties both for cadherin as a mechanotransductor and for the formation of cell-cell adhesion. In th...
关键词：cell-cell adhesion CADHERIN STIFFNESS STRENGTH molecular dynamic simulations 
Insulin receptor-like ectodomain genes and splice variants are found in both arthropods and human brain cDNA
《Journal of Systematics and Evolution》2013年第6期-,共7页(A)ke V(a)STERMARK Mathias RASK-ANDERSEN Rahul S.SAWANT Jill L.REITER Helgi B.SCHI(O)TH Michael J.WILLIAMS 
关键词：DROSOPHILA ECTODOMAIN INSR INSRR receptor L domain Tribolium castaneum 
Glycosylation of recombinant human thyroid peroxidase ectodomain of insect cell origin has little effect on recognition by serum thyroid peroxidase antibody被引量：7
《Chinese Medical Journal》2013年第15期2907-2911,共5页LILT Ming-ming LI Qing ZHAO Lan-lan GAO Ying HUANG You-yuan LU Gui-zhi GAO Yan-ming GUO Xiao-hui SHI Bing-yin 
Background Thyroid peroxidase （TPO） is an important autoantigen in Hashimoto＇s thyroiditis （HT）, and almost all epitopes are located in TPO ectodomain. The glycosylation of TPO might contribute to breaking self-t...
关键词：thyroid peroxidase baculovirus expression vector system sialic acid GALACTOSE FUCOSE 
Inhibitory role of TACE/ADAM17 cytotail in protein ectodomain shedding被引量：2
《World Journal of Biological Chemistry》2011年第11期246-251,共6页Liliana Pérez 
Supported by Grants from the National Institutes of Health,No.AG029859; the National Center of the American Heart Association,No.0330335N;the New Jersey Commission on Cancer Research(NJCCR703010)to Fan H
AIM:To determine if the cytotail of the principal sheddase tumor necrosis factor-α converting enzyme (TACE;ADAM17) controls protein ectodomain shedding.METHODS:Site-directed mutagenesis was performed to derive TACE v...
关键词：ADAM17 ECTODOMAIN SHEDDING L-SELECTIN Tumor NECROSIS factor-α converting enzyme 
Screening of Peptide Inhibitors of TACE from a Phage Display Random 15-Peptide Library by Recombinant TACE Ectodomain
《Frontiers in Biology》2006年第1期56-60,共5页Huang Wei Yang Yuzhen Wang Zhen Hang Ling 
supported by National Nature Science Foundation of China (No.30070722).
Tumor necrosis factor(TNF)-α-converting enzyme(TACE)is the major protease responsible for processing pro-TNF-αfrom membrane-anchored precursors to secreted TNF-α.In the present study,a 15-peptide library was used t...
关键词：TACE ECTODOMAIN phage display random peptide library peptide inhibitor 
Screening of TACE Peptide Inhibitors from Phage Display PeptideLibrary
《Journal of Huazhong University of Science and Technology(Medical Sciences)》2005年第5期473-476,共4页黄巍 李凌波 韩玲 杨渝珍 
ThisworkwassupportedbygrantsfromTheNationalNaturalSciencesFoundationofChina(No.30070722)andPublicHealthBureauFoundationofHubeiProvince(No.JX1B098).
Summary： To obtain the recombinant tumor necrosis factor-α converting enzyme （TACE） ectodomain and use it as a selective molecule for the screening of TACE peptide inhibitors, the cDNA coding catalytic domain （T...
关键词：tumor necrosis factor-α converting enzyme ECTODOMAIN prokaryote expression phage display peptide inhibitor 
Expression of Hepatitis C Virus E2 Ectodomain in E.coli and Its Application in the Detection of Anti-E2 Antibodies in Human Sera被引量：2
《Acta Biochimica et Biophysica Sinica》2004年第1期57-63,共7页JingLIU Xin-XinZHANG Shen-YingZHANG MinLU Yu-YingKONG YuanWANG Guang-DiLI 
This work was supported by a grant from the National High Technology Research and Development Program of China (863 Program) (No. 2001AA215171)
The second envelope glycoprotein (E2) of hepatitis C virus has been shown to bind human target cells and has become a major target for the development of anti-HCV vaccines. Anti-E2 antibodies have been suggested to be...
关键词：hepatitis C virus envelope protein E2 expression and purification Escherichia coll 
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