Background: L-selectin (CD62L) is a cell surface adhesion molecule recently shown to play a critical role in determining endometrial receptivity and implantation in humans. By contrast, the L-selectin ligand is missin...
Supported by Grants from the National Institutes of Health,No.AG029859; the National Center of the American Heart Association,No.0330335N;the New Jersey Commission on Cancer Research(NJCCR703010)to Fan H
AIM:To determine if the cytotail of the principal sheddase tumor necrosis factor-α converting enzyme (TACE;ADAM17) controls protein ectodomain shedding.METHODS:Site-directed mutagenesis was performed to derive TACE v...