Science Foundation of China (No. 30270507 and No. 30371581), Beijing Natural Science Foundation of China (No. 7022025), Fund of the National Ministry of Science and Technology of China (No. 2003ccc01300) to XU Rong-kun, and China Postdoctoral Science Foundation to YANG Quan-hui.
Background Our earlier studies indicate that melatonin inhibits the proliferation of prolactinoma and induces apoptosis of pituitary prolactin-secreting tumor in rats. Melatonin has also been shown to induce apoptosis...
Rats were implanted subcutaneously with silastic capsules containing 10 mg 17-β-estradiol. After 30, 60 and 120 days, their pituitary weights and plasma PRL levels were found to increase significantly. The administra...