supported by the National Cancer Institute(NCI)of the National Institutes of Health(NIH)(R03CA181893 and R01CA174926 to JLF,T32CA00923,P30CA023074);METAvivor(Translational Research Award,JLF);the Phoenix Chapter of ARCS Foundation(JNC);and the Louise Foucar Marshall Foundation Dissertation Fellowship(JNC).
Aim:Estrogen receptorα-positive(ER+)subtypes of breast cancer have the greatest predilection for forming osteolytic bone metastases(BMETs).Because tumor-derived factors mediate osteolysis,a possible role for tumoral...