supported by the National Natural Science Foundation of China(No.82160842);Project of Science and Technology Bureau of Chengguan District,Lanzhou City(No.2021SHFZ0017);Ministry of Education Key Laboratory Open Project(No.DHYX23-07);Gansu Province Chinese Medicine Research Program in 2023(No.GZKP-2022-40);Joint Research Fund General Program(No.23JRRA1521);Double First-Class Scientific Research Key Project Topics in 2023(No.GSSYLXM-05).