funded by the National Natural Science Foundation of China(82201153);the Natural Science Foundation of Shandong Province(ZR2022QH_(2)76);the National Key Research and Development Program of China(2023YFE0206700);the Key Research and Development Program of Shandong Province(2021ZDSYS14);the Academic Promotion Program of Shandong First Medical University(2019ZL001 and 2019RC008);the Taishan Scholar Program(20161059).