supported by the National Key Basic Research Program of China(973projects2009CB930200);the program of National Natural Science Foundation of China(30970784and81171455);the support of the Chinese Academy of Sciences(CAS)"Hundred Talents Program"and CAS Knowledge Innovation Program
Multidrug resistance(MDR),which significantly decreases the efficacy of anticancer drugs and causes tumor recurrence,has been a major challenge in clinical cancer treatment with chemotherapeutic drugs for decades.Seve...