supported by the National Natural Science Foundation of China (11272014 and 11328201);the National Key Basic Research Program of China (2013CB531200)
In cardiac myocytes,the sarcoplasmic reticulum(SR)is the main storage organelle of free Ca^(2+).The concentration of free Ca^(2+)in the SR is 0.5–1.0 mmol/L and is 2–3 orders of magnitude greater than that in the cy...