Β-GLOBIN

作品数:20被引量:4H指数:1
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相关领域:医药卫生生物学更多>>
相关机构:西北农林科技大学更多>>
相关期刊:《Chinese Medical Journal》《中国实验血液学杂志》《Progress in Natural Science:Materials International》《Science China Chemistry》更多>>
相关基金:国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划更多>>
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  • 期刊=Journal of Genetics and Genomicsx
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The origin of two divergent ovine β-globin haplotypes and their potential association with environmental adaptation
《Journal of Genetics and Genomics》2024年第8期877-879,共3页Yuxin Kang Yilin Liang Fengting Fan Hojjat Asadollahpour Nanaei Chunna Cao Yu Jiang Xianyong Lan Chuanying Pan Ran Li 
supported by the Sci-Tech Innovation 2030 Agenda(2022ZD0401403);Natural Science Basic Research Plan in Shaanxi Provine of China(2023-JC-YB-157);supported by the National Natural Science Foundation of China(U21A20120);Shaanxi Livestock and Poultry Breeding Double-chain Fusion Key Project(2022GD-TSLD-46-0401).
Hemoglobin is responsible for transporting oxygen from the lungs to body tissues.Structurally,this protein is a tetramer composed of two a-globin chains and twoβ-globin chains.In sheep,the β-globin locus is of parti...
关键词:CHAINS ALTITUDE SIMILARITY 
Amelioration of β^(654)-thalassemia in mouse model with the knockdown of aberrantly spliced β-globin mRNA被引量:1
《Journal of Genetics and Genomics》2008年第10期595-601,共7页Shuyang Xie Wei Li Zhaorui Ren Jingzhi Zhang Xinbin Guo Shu Wang Shuzhen Huang Fanyi Zeng Yi-Tao Zeng 
the National Basic Research Program of China (973 Program) (No 2004CB518806);the National High-tech R&D Program (863 Program) (No 2007AA021206);the National Natural Science Foundation of China (No 30571777);the Chinese National and Shanghai Leading Academic Disci-pline Project (No B204)
Large amounts of aberrantly spliced mRNA from the β^654 allele was present in erythroid cells, which might impair the erythropoiesis. A therapeutic strategy for β-thalassemia was explored by knocking down the aberra...
关键词:Β-THALASSEMIA small interfering RNA (siRNA) HEMOGLOBIN 
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