supported by the Sci-Tech Innovation 2030 Agenda(2022ZD0401403);Natural Science Basic Research Plan in Shaanxi Provine of China(2023-JC-YB-157);supported by the National Natural Science Foundation of China(U21A20120);Shaanxi Livestock and Poultry Breeding Double-chain Fusion Key Project(2022GD-TSLD-46-0401).
Hemoglobin is responsible for transporting oxygen from the lungs to body tissues.Structurally,this protein is a tetramer composed of two a-globin chains and twoβ-globin chains.In sheep,the β-globin locus is of parti...
the National Basic Research Program of China (973 Program) (No 2004CB518806);the National High-tech R&D Program (863 Program) (No 2007AA021206);the National Natural Science Foundation of China (No 30571777);the Chinese National and Shanghai Leading Academic Disci-pline Project (No B204)
Large amounts of aberrantly spliced mRNA from the β^654 allele was present in erythroid cells, which might impair the erythropoiesis. A therapeutic strategy for β-thalassemia was explored by knocking down the aberra...