Β-GLOBIN

作品数：20被引量：4H指数：1
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相关领域：医药卫生生物学更多>>
相关机构：西北农林科技大学更多>>
相关期刊：《Chinese Medical Journal》《中国实验血液学杂志》《Progress in Natural Science:Materials International》《Science China Chemistry》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划更多>>
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The origin of two divergent ovine β-globin haplotypes and their potential association with environmental adaptation
《Journal of Genetics and Genomics》2024年第8期877-879,共3页Yuxin Kang Yilin Liang Fengting Fan Hojjat Asadollahpour Nanaei Chunna Cao Yu Jiang Xianyong Lan Chuanying Pan Ran Li 
supported by the Sci-Tech Innovation 2030 Agenda(2022ZD0401403);Natural Science Basic Research Plan in Shaanxi Provine of China(2023-JC-YB-157);supported by the National Natural Science Foundation of China(U21A20120);Shaanxi Livestock and Poultry Breeding Double-chain Fusion Key Project(2022GD-TSLD-46-0401).
Hemoglobin is responsible for transporting oxygen from the lungs to body tissues.Structurally,this protein is a tetramer composed of two a-globin chains and twoβ-globin chains.In sheep,the β-globin locus is of parti...
关键词：CHAINS ALTITUDE SIMILARITY 
β-Globin Gene Cluster Haplotypes and Clinical Severity in Sickle Cell Anemia Patients in Southern Brazil
《Open Journal of Blood Diseases》2014年第2期16-23,共8页Maria ALda Silva Joao RFriedrisch Christina MBittar Meide Urnau Joice Merzoni Vanessa SValim Bruna Amorin Annelise Pezzi Jose Artur BChies Lucia Mda Rocha Silla 
Research and Event Incentive Fund of Hospital de Clinicas de Porto Alegre (FIPEHCPA)
Hematopoietic stem cell transplantation(HSCT)has emerged as a curative strategy for sickle cell anemia(SCA);it is necessary to find markers of SCA clinical severity to spare those SCA patients whose clinical course is...
关键词：Sickle Cell Anemia Β-GLOBIN Fetal Hemoglobin and Clinical Severity 
Analysis of Distribution of Thalassemic Genotype and Clinical Phenotype被引量：1
《Journal of Reproduction and Contraception》2013年第3期143-150,共8页Li-hua LU Jing YU Yin-han ZHANG Xia-feng WU Xiao-yi LIU 
Objective To determine the incidence of Thalassemia, the distribution of Thalassemic genotype and clinical phenotype. Methods Reverse dot blot （RDB） hybridization was used to detect the common three a-globin gene de...
关键词：THALASSEMIA a-globin gene deletion β-globin gene mutation GENOTYPE 
Co-Inheritance of Beta &Delta-Globin Gene (HbYialousa) Mutations in an Iranian <i>β</i>-Thalassemia Carrier
《International Journal of Clinical Medicine》2012年第7期633-636,共4页Atefeh Valaei Farnaz Eghbalpour Zahra Kainimoghaddam Fatemeh Bayat Maryam Taghavi Basmanj Morteza Karimipoor Sirous Zeinali 
Introduction: Beta-thalassemia is characterized by absence or reduced synthesis of the β-globin. Carriers of β-thalas- semia, typically have microcytic hypochromic anemia and elevated hemoglobin HbA2 and normal HbF ...
关键词：δ-Globin GENE Β-THALASSEMIA HbYialousa Β-GLOBIN GENE CD39 
Amelioration of β^(654)-thalassemia in mouse model with the knockdown of aberrantly spliced β-globin mRNA被引量：1
《Journal of Genetics and Genomics》2008年第10期595-601,共7页Shuyang Xie Wei Li Zhaorui Ren Jingzhi Zhang Xinbin Guo Shu Wang Shuzhen Huang Fanyi Zeng Yi-Tao Zeng 
the National Basic Research Program of China (973 Program) (No 2004CB518806);the National High-tech R&D Program (863 Program) (No 2007AA021206);the National Natural Science Foundation of China (No 30571777);the Chinese National and Shanghai Leading Academic Disci-pline Project (No B204)
Large amounts of aberrantly spliced mRNA from the β^654 allele was present in erythroid cells, which might impair the erythropoiesis. A therapeutic strategy for β-thalassemia was explored by knocking down the aberra...
关键词：Β-THALASSEMIA small interfering RNA （siRNA） HEMOGLOBIN 
The interaction between the human β-globin locus control region and nuclear matrix
《Cell Research》2002年第5期411-416,共6页SHU BING ZHANG, Ruo LAN QIANState Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China 
supported by the National Natural Science Foundation of China(Grant No.39893320 and 39870378);the Foundation of the Chinese Academy of Sciences (Grant No. KJ982-J1-618).
Our previous study showed that hydroxyurea (Hu) could induce HEL cells to express humanβ-globin gene. However the molecular mechanisms by which the expression of β-globin gene is activated and regulated are poorly u...
关键词：human β-globin LCR nuclear matrix proteins nuclear matrix HEL cells. 
Adeno-associated virus-mediated integration and expression of humanβ-globin gene with the core fragment of locus control region in erythroid cells
《Progress in Natural Science:Materials International》2000年第6期76-80,共5页李斌 刘德培 王晶 董文吉 郭志晨 夏薇 梁植权 
Project supported by Chinese National High Technology Development Program (BH-03-02-02).
To improve the integration stability and expression of the transferred human β- globin gene, the two recombinant adeno-associated virus (AAV) vectors containing the human β-globin gene with a single or multiple DNas...
关键词：HUMAN Β-GLOBIN gene LOCUS control region CORE FRAGMENT ADENO-ASSOCIATED virus vector. 
DNA-protein interaction at erythroid important regulatory elements of MEL cells bv in vivo footprinting
《Chinese Science Bulletin》2000年第12期1101-1108,共8页Jl Xinjun, LIU Depei, XU Dongdong, LI Lei, WANG Jing & LIANG ZhiquanNational Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Faculty of Basic Medical Sciences, Peking Union Medical College, Beijing 100005, China 
Using ligation-mediated PCR method to study the status of DNA-protein interaction at hypersensitive site 2 of locus control Region and βmaj promoter of MEL cell line before and after induction, MEL cell has been cult...
关键词：Β-GLOBIN GENE HS LM-PCR in VIVO FOOTPRINTING MEL cell line. 
HS3 of the mouse β-LCR被引量：2
《Chinese Science Bulletin》1997年第24期2090-2093,共4页TANG Yi QIAN RuolanShanghai Institute of Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China 
THE β-like globin gene cluster in human is very homologous to that in mouse. The locuscontrol region (LCR) which is contained in 20 kb upstream of the E-globin gene consists offour erythrold-specif1c DNaseⅠhypersens...
关键词：MOUSE Β-GLOBIN gene cluster locus control region DNASE Ⅰ HYPERSENSITIVE site 3. 
Retroviral mediated human β-globin gene transfer and expression in vitro
《中国实验血液学杂志》1997年第3期286-286,共1页Depei Liu, Chih-Chuan Liang National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005 
Retroviral mediated gene transfer of humanglobin gene into hematopoietic stem cells is apromising approach for thalassemia gene therapy.Major problem of the transferred globin gene was lowlevel expression of the gene ...
关键词：GLOBIN HEMATOPOIETIC proximal HYPERSENSITIVE locus enhancer packaging Major transferred induction 
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