云南高校图书馆联盟文献共享服务平台- DNASE

DNASE: 作品数：145被引量：194H指数：6; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：廖成水贺波冯伟兴王晓利刘明远更多>>; 相关机构：吉林大学哈尔滨工程大学河南科技大学武汉大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家重点实验室开放基金博士科研启动基金更多>>

miR-142-5p通过影响紧密连接蛋白CLDN1的表达介导旋毛虫Ts-DNaseⅡ-7的肠屏障损伤作用: 《中国兽医学报》2024年第7期1458-1465,1482,共9页鄂玉婷王静孙奕成刘晓雷吾拉木江·阿布来孜王存洲丁静; 吉林省自然科学基金资助项目(20220508052RC,20220101294JC)。; 旋毛虫进入宿主后,脱囊幼虫(肠道感染性第1期幼虫)进入宿主的小肠上皮细胞内继续发育,是旋毛虫感染并致病的关键步骤。本课题组前期研究结果显示,旋毛虫成虫期Ts-DNaseⅡ-7蛋白通过影响肠屏障,促进旋毛虫侵入肠上皮细胞,从而有利于其在...; 关键词：旋毛虫 miR-142-5p 肠道屏障通透性 CLDN1

应用DNase-SISPA方法检测环尾狐猴源未知病原的感染: 《当代畜牧》2024年第4期19-21,共3页蒋丽霞代军威单芬; 某动物园圈养的环尾狐猴发生了一种以高烧不退,精神沉郁,活动减少等症状为特征的急性疾病。笔者对发病死亡的动物进行剖检,采集肺、脑、肝等组织,接种vero细胞,72小时后细胞出现明显病变。在病原核酸背景未知的情况下,应用非序列依赖性...; 关键词：环尾狐猴 DNase—SISPA Waddlia chondrophila

Neuronal double-stranded DNA accumulation induced by DNase II deficiency drives tau phosphorylation and neurodegeneration: 《Translational Neurodegeneration》2024年第1期530-546,共17页Ling-Jie Li Xiao-Ying Sun Ya-Ru Huang Shuai Lu Yu-Ming Xu Jing Yang Xi-Xiu Xie Jie Zhu Xiao-Yun Niu Dan Wang Shi-Yu Liang Xiao-Yu Du Sheng-Jie Hou Xiao-Lin Yu Rui-Tian Liu; supported by funding from the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB39050600);the National Natural Science Foundation of China(82150107 and 81971073);the National Key Research and Development Program of China(2020YFA0712402).; Background Deoxyribonuclease 2(DNaseⅡ)plays a key role in clearing cytoplasmic double-stranded DNA(dsDNA).Deficiency of DNaseⅡleads to DNA accumulation in the cytoplasm.Persistent dsDNA in neurons is an early pathol...; 关键词：DNaseⅡ Alzheimer’s disease Double-stranded DNA Tau phosphorylation TAUOPATHY

DNase Ⅰ预处理和样本储存时间对血浆中性粒细胞胞外诱捕网相关指标检测结果的影响: 《检验医学》2024年第2期181-184,共4页彭瑞王芳丛祥凤苏建荣陈曦; 国家自然科学基金项目(82202594);中国医学科学院医学与健康科技创新工程(2017-I2M-3-003);首都医科大学附属北京友谊医院“友谊种子计划”人才项目(YYZZ202249)。; 目的分析DNase Ⅰ预处理和样本储存时间对血浆样本中性粒细胞胞外诱捕网(NET)检测结果的影响。方法随机筛选无基础疾病且无吸烟史的4名体检健康者,采集其外周血,提取血浆,检测NET的4个代表性指标[双链DNA(dsDNA)、瓜氨酸化组蛋白3(cit...; 关键词：中性粒细胞胞外诱捕网 DNaseⅠ预处理储存时间血浆

仿DNase酶的双金属分级多孔MOFs:制备与抗细菌生物膜应用被引量：1: 《Science China Materials》2024年第1期343-354,共12页夏凡李可杨健陈婧雯刘熙濛龚鸣顾金楼; financially supported by the National Natural Science Foundation of China (22275054,52103314,21975072,and 51902106);Chenguang Plan of Shanghai Education Development Foundation (21CGA38);the Program of Shanghai Academic/Technology Research Leader (23XD1401000)。; 本研究成功构建了具有切割DNA能力的双金属枝状大孔金属有机框架(MOFs;HMUiO-66(Zr/Ce)),并将其用于高效破坏生物膜并抑制细菌生长.通过改变Zr/Ce的投料比,可在0-69%的范围内精确调控Zr/Ce的引入量,并控制其粒径在1μm-150 nm之间.HMUiO...; 关键词：金属有机框架细菌生物膜双金属医疗器械水解速率细菌粘附 PVDF膜大孔结构

The influence of the copy number of invader on the fate of bacterial host cells in the antiviral defense by CRISPR-Cas10 DNases: 《Engineering Microbiology》2023年第4期38-47,共10页Zhenxiao Yu Jianan Xu Yan Zhang Qunxin She; supported by grants from the National Key R&D Pro-gram of China(2021YFA0717000);the National Natural Science Foun-dation of China(31771380)to QS;from the China Postdoctoral Sci-ence Foundation(2020M672050);the Qingdao Applied Research Fund For Postdoctoral Researchers(62450079311107)to ZY;an Open Project from the State Key Laboratory of Microbial Technology at Shan-dong University.; Type Ⅲ CRISPR-Cas10 systems employ multiple immune activities to defend their hosts against invasion from mobile genetic elements(MGEs),including DNase and cyclic oligoadenylates(cOA)synthesis both of which are hoste...; 关键词：TypeⅢCRISPR systems Target RNA-activated Cas10 DNase Invader copy number Plasmid interference assay Abortive infection Invader clearance

C-176 loaded Ce DNase nanoparticles synergistically inhibit the cGAS-STING pathway for ischemic stroke treatment被引量：6: 《Bioactive Materials》2023年第11期230-240,共11页Zhixin Zhu Haipeng Lu Lulu Jin Yong Gao Zhefeng Qian Pan Lu Weijun Tong Pik Kwan Lo Zhengwei Mao Haifei Shi; the National Natural Science Foundation of China(No.22161132027,82272465,and 52273152);Zhejiang Provincial Natural Science Foundation of China(LY20H060008);the Starry Night Science Fund of Zhejiang University Shanghai Institute for Advanced Study(SN-ZJU-SIAS-006);‘Open Competition to Select the Best Candidates’Key Technology Program for Nucleic Acid Drugs of NCTIB(Grant No.NCTIB2022HS02006);Zhejiang High-Level Young Talent Special Support Plan for Dr.Zhengwei Mao.; The neuroinflammatory responses following ischemic stroke cause irreversible nerve cell death.Cell free-double strand DNA(dsDNA)segments from ischemic tissue debris are engulfed by microglia and sensed by their cyclic...; 关键词：Ischemic stroke Ce-based nano-nuclease The cGAS-STING signaling pathway Anti-inflammation

Aggregation-induced emission artificial enzyme(AIEzyme)with DNase-like activity:Imaging and matrix cleavage for combating bacterial biofilm: 《Aggregate》2023年第5期161-173,共13页Lei Han Yucui Zhang Baojian Huang Xuhui Bian Ben Zhong Tang; Youth Innovation Team Project for Talent Introduction and Cultivation in Universities of Shandong Province,Grant/Award Number:096-1622002;Research Foundation for Distinguished Scholars of Qingdao Agricultural University,Grant/Award Number:663-1117015。; DNase-catalyzed hydrolysis of extracellular DNA(eDNA)has been widely employed to eradicate intractable biofilms.Although aggregation-induced emission(AIE)has become the ideal tool for killing planktonic bacteria,AIE l...; 关键词：aggregation-induced emission artificial enzyme BIOFILM DNASE extracellular DNA

DNaseⅠ对痤疮丙酸杆菌生物膜的抑制效应研究: 《中华皮肤科杂志》2023年第10期920-924,共5页周蒙郑娜娜曾荣徐浩翔段志敏刘宇甄李岷; 国家自然科学基金(82173432、82103749);江苏省“双创博士”项目(JSSCBS20211610)。; 目的探讨DNaseⅠ对痤疮丙酸杆菌生物膜的抑制效应。方法构建痤疮丙酸杆菌生物膜并给予DNaseⅠ处理,分为不同DNaseⅠ浓度组(0、5、10、20 U/ml)。采用四甲基氮盐法检测生物膜活力,结晶紫半定量法检测生物膜含量,激光共聚焦显微镜观察生...; 关键词：痤疮丙酸杆菌生物膜脱氧核糖核酸酶Ⅰ

Synergistic effect of schizandrin A and DNaseⅠknockdown on high glucose induced beta cell apoptosis by decreasing intracellular calcium concentration: 《Journal of Traditional Chinese Medicine》2023年第4期661-666,共6页ZHU Bin YU Ning WANG Lei TIAN Yue WU Mingfen ZHAO Zhigang; the Natural Science Foundation of China:the Protective Effect of Schizandrin A toβCell Apoptosis by DNaseⅠin Type 2 Diabetes(No.81803909)。; OBJECTIVE:To explore the synergistic effect of deoxyribonucleaseⅠ(DNaseⅠ)knockdown combined with Schizandrin A(Sch A)in protecting islet beta-cells(β-cells)from apoptosis under high-glucose(HG)conditions.METHODS:Th...; 关键词：high glucose DIABETES β-cell apoptosis synergistic effect Schizandrin A

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

DNASE

检索结果分析

下载全文

高级检索检索式检索

时间限定

期刊范围

学科限定全选

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

DNASE

检索结果分析

下载全文

用户登录

高级检索检索式检索