云南高校图书馆联盟文献共享服务平台- PEPTIDE

PEPTIDE: 作品数：1062被引量：2043H指数：15; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：杨松成张学敏张滨魏开华王红霞更多>>; 相关机构：北京大学福建医科大学复旦大学军事医学科学院更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金国家高技术研究发展计划更多>>

Selective Enrichment of Low-Abundance DNA Variants Based on Programmable Peptide Nucleic Acid Probes: 《Chinese Journal of Chemistry》2024年第21期2572-2580,共9页Yi Zhang Zhi Weng Zixuan Huang Qian Li Chunhai Fan Shihua Luo Ping Song; support from the National Key R&D Program of China(2021YFF1200300);the National Natural Science Foundation of China(Nos.22174094,22274097);the Fundamental Research Funds for the Central Universities(YG2023QNA33);Young Leading Scientists Cultivation Plan supportedby ShanghaiMunicipal Education Commission(ZXWH1082101).; Single-nucleotide variants(SNVs)are crucial in disease development,but their accurate detection is challenging due to their low abundance and interference from wild-type targets.Although nucleic acid analogs like pept...; 关键词：Peptide nucleic acids THERMODYNAMICS Strand displacement reaction SNVs detection Biosensors Nucleic Acids KINETICS

Access to Enantioenriched Allylic Alcohols via Peptide-Mimic Phosphonium Salt-Catalyzed Asymmetric Aerobic Hydroxylation: 《Chinese Journal of Chemistry》2024年第17期2017-2022,共6页Jixing Che Siqiang Fang Zanjiao Liu Jiaja He Jia-Yan Zheng Fan Wang Tianli Wang; Financial support was provided by the National Natural Science Foundation of China(22222109,21921002,22101189 and 22371190);the National Key R&DProgramof China(2018YFA0903500);Beijing National Laboratory for Molecular Sciences(BNLMs202101);Sichuan Science Foundation for Distinguished Young Scholars(2023NSFSC1921);Sichuan Provincial Natural Science Foundation(2022NSFSC1181,24NSFSC6590);Fundamental Research Funds from Sichuan University(2020SCUNL108)and Fundamental Research Funds for the Central Universities.; The development of catalytic asymmetric methods that enable access to value-added functionalities or structures,exemplified by allylic alcohols,is a highly interesting yet challenging topic from both academic and indu...; 关键词：Asymmetric catalysis Peptide-mimic phosphonium salts Aerobic hydroxylation Enantioenrichedα-allylic alcohols lon pairs Oxygen Ketones

Mechanistic Investigations into the Catalytic Mode of a Dehydratase Complex Involved in the Biosynthesis of Lantibiotic Cacaoidin被引量：1: 《Chinese Journal of Chemistry》2023年第24期3579-3586,共8页Yanqing Xue Miao Li Ling Hu Jianing Liu Lifeng Pan Wen Liu; supported in part by grants from the National Key Research and Development Program of China(2022YFC2303100 for L.P and W.L);the National Natural Science Foundation of China(32030002 and 22193070 for W.L);the Science and Technology Commission of Shanghai Municipality(20XD1425200 for L.P);the CAS Youth Interdisciplinary Team(JCTD-2022-10 for L.P).; Dehydration of serine/threonine residues necessitates the activity of a dehydratase enzyme(domain)during the biosynthesis of RiPP.Recently,it was reported that dehydration in the thioviridamide pathway relies on a dis...; 关键词：Ribosomally synthesized and post-translationally modified peptide ANTIBIOTICS Enzyme models Natural products Dehydratase complex Cacaoidin Dehydration reaction

Unravelling the Structural Development of Peptide-Coordinated Iron-Sulfur Clusters:Prebiotic Evolution and Biosynthetic Strategies被引量：1: 《Chinese Journal of Chemistry》2022年第12期1478-1491,共14页Yijun Dong Siqi Zhang Liang Zhao; Iron-sulfur(Fe-S)proteins are among the most common type of natural metalloproteins that participate in a large range of key metabolic processes.To date,enormous research works on the exploration of protein structures...; 关键词：PEPTIDES Iron-sulfur clusters Prebiotic evolution BIOSYNTHESIS Biomimetic synthesis

Peptide or Protein-Protected Metal Nanoclusters for Therapeutic Application被引量：1: 《Chinese Journal of Chemistry》2022年第2期267-274,共8页Xiaolei Chen Xiaojun Ren Xueyun Gao; This work was supported by grants from the National Natural Science Foundation of China(21904009,21727817,11621505,21877029,U2067214,21727817);the Capital Science and Technology Leading Talent Training Project(Z191100006119023);Beijing Municipal Natural Science Foundation(2202003).; What is the most favorite and original chemistry developed in your research group?The most favorite and original work we have done is the development of gold nano clusters for diagnostic and therapeutic application.Ho...; 关键词：Metal nanoclusters BIOCOMPATIBILITY PEPTIDES Cell apoptosis Therapeutic mechanism

A Peptide Binder of E3 Ligase Adaptor SPOP Disrupts Oncogenic SPOP-Protein Interactions in Kidney Cancer Cells: 《Chinese Journal of Chemistry》2021年第2期274-280,共7页Zhen Wang Hao Zhang Baoen Chen Sisheng Ouyang Tong Zheng Ran Zhou Ze Dong Yue Huang Tao Zhang Hualiang Jiang Jianhua Gan Cheng Luo Cai-Guang Yang; This work was supported by the National Natural Science Foundation of China(No.21725801 to C.-G.Y,Nos.81625022 and 81430084 to C,L,and No.21807103 to 2.D.);the National Key New Urug Lreation and Manufacturing Program,Ministry of Science and Technology(No.20182X09711002 to Z.D.);the Science and Technology Commis-sion of Shanghal munltlpallty(NB.18YF1428500 to Y.H.alu Nu..18431907100 to H.J.J;the China Postdoctoral Science Foun-dation(No.2018M640434 to Y.H.,No.2017M621570 to Z.D.,and Nu.2018M032187 lwT.L).; The E3 ligase adaptor SPOP,overexpressed in the nucleus but frequently dislocated into the cytoplasm in all clear cell Renal Cell Carcinomas(ccRCC),serves as a regulatory hub to promote kidney cancer through the ubiqu...; 关键词：SPOP Protein-protein interaction Clear cell Renal Cell Carcinomas Crystal structure Peptide inhibitor

Energy Transfer of Peptide Ions Colliding with a Self-Assembled Monolayer Surface. The Influence of Peptide Ion Size被引量：1: 《Chinese Journal of Chemistry》2019年第3期237-243,共7页Meng Gu Li Yang William L Hase Jianmin Sun Jiaxu Zhang; Summary of main observation and conclusion Atomistic dynamics of protonated polyglycine, glyn-H^+(n = 3, 5, and 7), colliding with a fluorinated octanethiol self-assembled monolayer (F-SAM) surface has been studied by...; 关键词：ENERGY TRANSFER PEPTIDE IONS Colliding

Bis‐Lactam Peptide [i, i + 4]‐Stapling被引量：1: 《Chinese Journal of Chemistry》2019年第3期244-248,共5页Xiao Hu Bo Wu Weiping Zheng; Summary of main observation and conclusion Even though the bis‐lactam peptide stapling with the [i, i + 7] and the [i, i + 11] systems has been known to be able to afford %α‐helicity values up to 100%(25°C), the p...; 关键词：BIS BIS HAS be our was can

Deformylated Gramicidin A and Its Derivatives Showing High Antimicrobial Activity and Low Hemolytic Toxicity被引量：1: 《Chinese Journal of Chemistry》2019年第1期25-29,共5页Wei-Wei Haoyang Min Zhang Jun-Li Hou; the National Natural Science Foundation of China (21725202,21572035);the National R&D Program of China (2017YFA0206901);STCSM (18XD1400800,18JC1411600)for financial support.; Summary of main observation and conclusion Gramicidin A is a natural peptide,which shows high antimicrobial activity to Gram-positive bacteria. However,the hemolytic toxicity prevents its therapeutic usage.We demonstr...; 关键词：PEPTIDE BUILD GROUP

Site-specific Analysis of Amyloid Assemblies by Using Scanning Tunneling Microscopy: 《Chinese Journal of Chemistry》2015年第1期24-34,共11页Yue Yu Yanlian Yang Chen Wang; supported by the National Natural Science Foundation of China (Nos.91127043,21273051,20911130229);the National Basic Research Program of China (Nos.2011CB932800,2009CB930100);the Chinese Academy of Sciences (No.KJCX2-YW-M15).; The assembly of amyloid peptides into highly organized fibrils is one of the major characteristics of many de-generative diseases such as Alzheimer’s disease and type II diabetes.Assembly structures of amyloid peptid...; 关键词：PEPTIDE AMYLOID ASSEMBLY scanning tunneling microscopy MUTATION

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

PEPTIDE

检索结果分析

下载全文

高级检索检索式检索

时间限定

期刊范围

学科限定全选

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

PEPTIDE

检索结果分析

下载全文

用户登录

高级检索检索式检索