This work was mainly supported by NIH grants R00AI106941 and R21AI120010;NSF CAREER Award 1653782,a Chicago Biomedical Consortium Catalyst Award(to J.H.);postdoctoral grant PDR-092(to D.K.S.),with additional support from the Searle Funds at The Chicago Community Trust;This work is also supported by NIH grant R01AI126756(to E.J.A.)and R01CA022677(to H.S.).
A major unanswered question is how a TCR discriminates between foreign and self-peptides presented on the APC surface.Here,we used in situ fluorescence resonance energy transfer(FRET)to measure the distances of single...