云南高校图书馆联盟文献共享服务平台- PTX

PTX: 作品数：130被引量：286H指数：8; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：张凌姚力赵望泓张烜陈璇更多>>; 相关机构：中日友好医院南方医科大学郑州大学北京大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划南方医科大学南方医院院长基金山西省青年科技研究基金更多>>

血液透析合并继发性甲状旁腺功能亢进患者PTX手术和西那卡塞药物治疗的成本效果分析--基于真实世界数据的研究被引量：8: 《中华内分泌外科杂志》2021年第6期661-665,共5页杨柳张凌杨莉; 国家自然科学基金(72174010,71673004,71911530221)。; 目的评价甲状旁腺切除术(parathyroidectomy,PTX)和拟钙剂西那卡塞治疗血液透析合并难治性继发性甲状旁腺功能亢进(secondary hyperparathyroidism,SHPT)的成本-效果。方法回顾性收集2016年1月到2019年1月中日友好医院收治的血液透析合...; 关键词：血液透析继发性甲状旁腺功能亢进西那卡塞甲状旁腺切除术成本-效果分析

Cathepsin B-responsive and gadolinium-labeled branched glycopolymer-PTX conjugate-derived nanotheranostics for cancer treatment被引量：4: 《Acta Pharmaceutica Sinica B》2021年第2期544-559,共16页Hao Cai Yufan Xiang Yujun Zeng Zhiqian Li Xiuli Zheng Qiang Luo Hongyan Zhu Qiyong Gong Zhongwei Gu Yanhui Liu Hu Zhang Kui Luo; financially supported by the National Natural Science Foundation of China(Nos.51873120,51673127,and 81621003);Department of Science and Technology of Sichuan Province(Nos.2018JY0574,2017SZ0006,18GJHZ0139,and 2018HH0006,China);1·3·5 Research Funds in West China Hospital of Sichuan University(ZYGD18028,China); Multi-modal therapeutics are emerging for simultaneous diagnosis and treatment of cancer.Polymeric carriers are often employed for loading multiple drugs due to their versatility and controlled release of these drugs ...; 关键词：STIMULI-RESPONSIVE Drug delivery Branched glycopolymers Biodegradability Nanomedicine THERANOSTICS

多硝基吡唑并[5,1-c][1,2,4]三嗪含能化合物合成与表征被引量：4: 《火炸药学报》2020年第6期614-619,共6页闫峥峰汪营磊陆婷婷赵宝东陈斌葛忠学; 国家自然科学基金(No.21875185,No.21805222,No.22005238)。; 为合成高能不敏感含能化合物,以3,4-二硝基吡唑为原料,经异常亲核取代氢(VNS)反应合成5-氨基-3,4-二硝基吡唑(ADNP),ADNP经重氮化后与硝基乙腈的钠盐偶合、分子内环化,合成多硝基氮杂芳香稠环含能化合物4-氨基-3,7,8-三硝基吡唑并[5,1-c...; 关键词：有机化学 5-氨基-3 4-二硝基吡唑 ADNP 4-氨基-3 7 8-三硝基吡唑并[5 1-c]1 2 4-三嗪 PTX 热分析撞击感度

Long non-coding RNA LINC-PINT attenuates paclitaxel resistance in triple-negative breast cancer cells via targeting the RNA-binding protein NONO被引量：6: 《Acta Biochimica et Biophysica Sinica》2020年第8期801-809,共9页Jinghua Chen Meiqin Zhu Liqiu Zou Junxian Xia Jiacheng Huang Quantong Deng Ruilian Xu; This work was supported by the grants from the Basic Research Project of Science and Technology Plan of Shenzhen(No.JCYJ20160422144516003);the National Natural Science Foundation of China(No.81771805).; The treatment of triple-negative breast cancer(TNBC)relies largely on chemotherapies.However,it is frequent that TNBC patients develop resistance to the chemotherapy drugs.Generation of drug-resistant cell lines facil...; 关键词：TNBC LINC-PINT paclitaxel(PTX) NONO lncRNA

Hyaluronic acid derivative-modified nano-structured lipid carrier for cancer targeting and therapy被引量：4: 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2020年第7期571-580,共10页Xiao LIU Hai LIU Su-lan WANG Jing-wen LIU; Project supported by the Zhejiang Provincial Natural Science Foundation of China(No.LY14H160016)。; To reduce the problems of poor solubility,high in vivo dosage requirement,and weak targeting ability of paclitaxel(PTX),a hyaluronic acid-octadecylamine(HA-ODA)-modified nano-structured lipid carrier(HA-NLC)was constr...; 关键词：Paclitaxel(PTX) Hyaluronic acid-octadecylamine(HA-ODA) Nano-structured lipid carrier(NLC) Tumor targeting In vivo distribution

PCN-Fe(Ⅲ)-PTX nanoparticles for MRI guided high efficiency chemo-photodynamic therapy in pancreatic cancer through alleviating tumor hypoxia被引量：8: 《Nano Research》2020年第1期273-281,共9页Tao Zhang Zhenqi Jiang Libin Chen Chunshu Pan Shan Sun Chuang Liu Zihou Li Wenzhi Ren Aiguo Wu Pintong Huang; supported by the National Natural Science Foundation of China(Nos.81527803,81420108018,U1432114,81550110258,8161101589,81650410654 and 31971292);National Key R&D Program of China(Nos.2018YFC0115900 and 2018YFC0910601);Key Breakthrough Program of Chinese Academy of Sciences(No.KGZD-EW-T06);Zhejiang Science and Technology Project(No.2019C03077);the Hundred Talents Program of Chinese Academy of Sciences(No.2010-735);Youth Natural Science Fund Project of Zhejiang Province(No.LQ19H180004);Natural Science Fund Project of Ningbo City(No.2018A610380);Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province(No.2019E10020)。; As nanomedicine-based clinical strategies have continued to develop,the possibility of combining chemotherapy and singlet oxygen-dependent photodynamic therapy(PDT)to treat pancreatic cancer(PaC)has emerged as a viabl...; 关键词：HYPOXIA porous-coordination polymers MRI imaging photodynamic therapy chemocherapy

Integration of phospholipid-drug complex into self-nanoemulsifying drug delivery system to facilitate oral delivery of paclitaxel被引量：1: 《Asian Journal of Pharmaceutical Sciences》2019年第5期552-558,共7页Dawei Ding Bingjun Sun Weiping Cui Qin Chen Xuanbo Zhang Haotian Zhang Zhonggui He Jin Sun Cong Luo; financially supported by the National Nature Science Foundation of China (No. 81703451);the China Postdoctoral Science Foundation (No. 2017M611269 and 2018T110233); Self-nanoemulsifying drug delivery system(SNEDDS) has emerged as a promising platform to improve oral absorption of drugs with poor solubility and low permeability. However,large polarity molecules with insufficient l...; 关键词：PTX PLDC SNEDDS PLDC-SNEDDS ORAL delivery

紫杉醇纳米复合物体内体外抗宫颈癌活性评价被引量：1: 《复旦学报（医学版）》2019年第4期485-493,共9页朱彩英陈武炼杜明徐丛剑; 上海市科委引导类项目(124119a2400);国家自然科学基金(81372796);上海卫计委科研项目(20124097)~~; 目的利用二硫键共价链接紫杉醇(paclitaxel,PTX)与荧光介孔二氧化硅纳米粒(fluorescent mesoporous silica nanoparticles,FMSN),形成一种可控药物投递系统(controlled drug delivery system,CDDS),并用体内体外实验评价其抗宫颈癌活性...; 关键词：介孔二氧化硅纳米粒(MSN) 紫杉醇(PTX) 可控药物投递系统(CDDS) 二硫键宫颈癌

Histology and antitumor activity study of PTX-loaded micelle,a fluorescent drug delivery system prepared by PEG-TPP被引量：2: 《Chinese Chemical Letters》2019年第5期1083-1088,共6页Huilan Li Jieming Li Xinyi He Bo Zhang Chunxia Liu Qifei Li Ying Zhu Wenlong Huang Wei Zhang Hai Qian Liang Ge; supported by grants from the National Natural Science Foundation of China(No.81872733);the Natural Science Foundation of Jiangsu Province of China(No.15KJB310004); We synthesized PEG-TPP as carrier to encapsulate paclitaxel (PTX) in the form of micelles to overcome its water-solubility problem. PTX-loaded micelles possess a-week stability and appropriate particle size (152.1 ±1...; 关键词：PEG-TPP ANTICANCER Micelles EPR Mitochondria

mTOR通路增强宫颈癌紫杉醇耐药细胞株HeLa/PTX对紫杉醇的敏感性被引量：6: 《沈阳药科大学学报》2019年第3期254-260,共7页张艳刘耀基侯桂琴陈楠; 国家自然科学基金资助项目(30901778);河南省基础与前沿技术研究计划项目(162300410122); 目的探讨mTOR在宫颈癌紫杉醇耐药中的作用及mTORC1/2双重抑制剂OSI-027联用紫杉醇后HeLa/PTX细胞对紫杉醇(paclitaxel,PTX)敏感性的变化并对相关机制进行研究。方法用sh-RNA-Raptor及sh-RNA-Rictor质粒转染HeLa/PTX细胞以下调Rictor及Ra...; 关键词：宫颈癌紫杉醇耐药 PI3K/AKT/mTOR信号通路 OSI-027

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