PUMA

作品数：646被引量：443H指数：9
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相关领域：医药卫生轻工技术与工程更多>>
相关作者：万福生张克君王玉明曾常茜余东升更多>>
相关机构：南昌大学中南大学昆明医科大学苏州大学更多>>
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相关基金：国家自然科学基金广东省自然科学基金江西省自然科学基金卫生部科学研究基金更多>>
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PUMA facilitates EMI 1-promoted cytoplasmic Rad51 ubiquitination and inhibits DNA repair in stem and progenitor cells
《Signal Transduction and Targeted Therapy》2021年第4期1377-1387,共11页Jin Wook Kang Zhiyan Zhan Guangzhen Ji Youzhou Sang Daohong Zhou Yanxin Li Haizhong Feng Tao Cheng 
This work was supported by the grants from the Ministry of Science and Technology of China(2016YFA0100600);the National Natural Science Foundation of China(81730006,81890990,81874078,82072896,81972341,and 81772663);CAMS Initiative for Innovative Medicine(2016-I2M-1-017,2019-I2M-1-006);Shanghai Municipal Science and Technology Commission(19JC1413500);Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant(No.20161310).
Maintenance of genetic stability via proper DNA repair in stem and progenitor cells is essential for the tissue repair and regeneration,while preventing cell transformation after damage.Loss of PUMA dramatically incre...
关键词：PROGENITOR PUMA repair 
PUMA PROMOTES BAX ACTIVATION IN A FOXO3a-DEPENDENT MANNER IN STS-INDUCED APOPTOSIS
《Journal of Innovative Optical Health Sciences》2010年第1期31-38,共8页YINGJIE ZHANG DA XING 
supported by the National Basic Research Program of China(2010CB732602);the Program for Changjiang Scholars and Innovative Research Team in University(IRT0829);the National Natural Science Foundation of China(30870676;30870658).
PUMA(p53 up-regulated modulator of apoptosis,also called Bbc3)was first identified as a BH3-only Bcl-2 family protein that is transcriptionally up-regulated by p53 and activated upon p53-dependent apoptotic stimuli,su...
关键词：PUMA Bax activation FOXO3A STS apoptosis 
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