目的:探究干扰素在Huh7.5.1细胞中对RNA编辑酶(adenosine deaminases acting on RNA 1,ADAR1)表达的影响,以及ADAR1对丙型肝炎病毒(hepatitis C virus,HCV)复制的调控作用。方法:干扰素(IFN-α,30 IU/m L)刺激Huh7.5.1细胞后,利用real-t...
supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB13020600);the National Natural Science Foundation of China(31671325)
RNA editing was first discovered in mitochondrial RNA molecular. However, whether adenosine-toinosine(A-to-I) RNA editing has functions in nuclear genes involved in mitochondria remains elusive.Here, we retrieved 707,...
载脂蛋白B m RNA编辑酶催化多肽3G(apolipoprotein B m RNA editing enzyme catalytic polypeptide-like 3G,APOBEC3G)是一种天然抗病毒因子,目前研究证明其具有抗乙肝病毒的作用。它可能通过影响HBV DNA逆转录、诱导HBV DNA超突变、包...