SIGNAL_TRANSDUCTION

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A new effect of IL-4 on human γδ T cells： promoting regulatory Vδ1 T cells via IL-10 production and inhibiting function of Vδ2 T cells被引量：8
《Cellular & Molecular Immunology》2016年第2期217-228,共12页Yujia Mao Shanshan Yin Jianmin Zhang Yu Hu Bo Huang Lianxian Cui Ning Kang Wei He 
We thank Dr Mingxiao He （Duke University for Immunology Research） for critical reading of this manuscript. This work was supported by the Research Special Fund for Public Welfare Industry of Health （Grant Nos. 201202004 and 201302018）, the National Program for Key Basic Research Projects, Ministry of Science and Technology, China （2013CB530503 and 2014CB542103）, the Beijing Natural Science Foundation （Grant No. 5122031）, the National Natural Science Foundation of China （Grant No. 30972776） and the National High Technology Research and Development Program （863 Program） （Grant No. 2007AA021109）. We thank Dr Austin Cape for careful reading and feedback.
Interleukin 4 （IL-4） has a variety of immune functions, including helper T-cell （Th-cell） differentiation and innate immune-response processes. However, the impact of IL-4 on gamma delta （γδ） T cells remains u...
关键词：CYTOKINES signal transduction T-cell receptors T cells tumor immunity 
p75NTR signal transduction suppressed by BFAR and p75NTR interactions被引量：1
《Science China(Life Sciences)》2012年第4期367-374,共8页LI HongMei SHI HuiLi HUO KeKe 
supported by the National High Technology Research and Development Program of China (Grant No. 2006AA02A310);National Science and Technology Key Program of China (Grant Nos. 2008ZX10003-006 and 2009ZX09301011);National Basic Research Program of China (Grant No. 2010CB912609) which were awarded to Huo KeKe
p75NTR is a low-affinity nerve growth factor receptor, which promotes cell proliferation as a positive modulator of high-affinity receptor TrkA, as well as binds with cell ligands to induce apoptosis and mediate death...
关键词：P75NTR BFAR membrane yeast two-hybrid protein-protein interaction APOPTOSIS 
Influence on Cellular Signal Transduction Pathway in Dairy Cow Mammary Gland Epithelial Cells by Galactopoietic Compound Isolated from Vaccariae segetalis被引量：11
《Agricultural Sciences in China》2011年第4期619-630,共12页WAN Zhong-ying TONG Hui-li LI Qing-zhang GAO Xue-jun 
supported by the National High Tech-nologies R&D Program (863 Program) of China(2006AA10Z1A4);the Innovation Team Project of Northeast Agricultural University, China (LXT005-1-2)
The galactopoietic mechanism of Vaccaria segetalis is still unknown. Understanding dibutyl phthalate （DBP） separated from Vaccaria segetalis on the expression of lactation signal transduction genes of mammary gland ...
关键词：Vaccaria segetalis DBP dairy cow mammary gland epithelial cells signal transduction MIRNAS 
Regulation of TGF-β signaling by Smad7被引量：49
《Acta Biochimica et Biophysica Sinica》2009年第4期263-272,共10页Xiaohua Yan Ziying Liu Yeguang Chen 
Acknowledgements The authors wish to apologize to the investigators whose outstanding work was not cited here because of space limitation. The authors would also like to thank Mr Martin Ting Ma for assisting in manuscript preparation.;Funding This work was supported by the grants from the National Natural Science Foundation of China （30430360, 30671033, and 30600096）, the Major State Basic Research Development Program of China （2004CB720002, 2006CB943401, and 2006CB910102）, and the National High Technology Research and Development Program of China （2006AA02Z 172）.
Transforming growth factor （TGF）-β is a pleiotropic cytokine regulating a variety of cellular processes such as cell growth, differentiation, apoptosis, migration, cell adhesion, and immune response. In the well-un...
关键词：TGF-Β signal transduction SMAD7 feedback loop CROSSTALK 
Role of Epstein-Barr Virus Encoded Latent Membrane Protein 1 in the Carcinogenesis of Nasopharyngeal Carcinoma被引量：34
《Cellular & Molecular Immunology》2007年第3期185-196,共12页Hui Zheng Lili Li Duosha Hu Xiyun Deng Ya Cao 
grants from State Key Basic Research and Development Plan （973） of the Ministry of Science and Technology of China （2004CB518703）; National High Technology Research and Development Program （863） of China （N0.2006AA02Z481）; National Science Fund for Distinguished Young Scholars 0verseas （30428008）; Hong Kong Cooperation Fund Project of National Natural Science Foundation of China （30418004）.
Epstein-Barr virus （EBV）-encoded latent membrane protein 1 （LMPI） has been known to have oncogenic properties during latent infection in nasopharyngeal carcinoma （NPC）. Our studies focused on the role of LMP1 in...
关键词：latent membrane protein 1 nasopharyngeal carcinoma signal transduction 
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