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NECAB family of neuronal calcium-binding proteins in health and disease
《Neural Regeneration Research》2025年第5期1236-1243,共8页Diones Bueno Michael K.E.Schafer Sudena Wang Michael J.Schmeisser Axel Methner 
supported by the Deutsche Forschungsgemeinschaft (ME1922/14-1) to AM。
The N-terminal EF-hand calcium-binding proteins 1–3(NECAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one EF-hand calcium-binding domain and a functionally le...
关键词：CALCIUM EF hand MITOCHONDRIA nervous system signal transduction 
Impacts of PI3K/protein kinase B pathway activation in reactive astrocytes: from detrimental effects to protective functions
《Neural Regeneration Research》2025年第4期1031-1041,共11页Ramón Pérez-Núñez María Fernanda González Ana María Avalos Lisette Leyton 
supported by Fondo Nacional de Desarrollo Científico y Tecnológico(FONDECYT)#1200836,#1210644,and#1240888,and Agencia Nacional de Investigación y Desarrollo(ANID)-FONDAP#15130011(to LL);FONDECYT#3230227(to MFG).
Astrocytes are the most abundant type of glial cell in the central nervous system.Upon injury and inflammation,astrocytes become reactive and undergo morphological and functional changes.Depending on their phenotypic ...
关键词：inflammation INTEGRINS NEUROPROTECTIVE NEUROTOXIC phosphatidylinositol 3-kinase reactive astrocytes signal transduction Thy-1(CD90) 
Pathways Related to ROS Production, Clearance, and Signal Transduction during Cold Response in Brassica napus L.with Strong Cold Resistance
《Phyton-International Journal of Experimental Botany》2025年第3期739-762,共24页Weiliang Qi Wancang Sun Li Ma Xiaolong Li Haiqing Liu Cairong Yang Ziyao Wei 
supported by the National Nature Science Foundation Regional Fund Project(32360455);QingyangCity Joint Research Fund Project—Major Project(QY-STK-2024A-046);Doctoral Foundation of Longdong University(XYBYZK2107);University Teachers Innovation Fund Project of Gansu Province(2025A-198).
Brassica napus L. (B. napus), recognized as a significant cash and oil crop, faces challenges in popularization and application in northern China due to its limited cold resistance. Clarifying the mechanism of cold st...
关键词：Brassica napus L. cold stress comparative transcriptome ROS 
Dysregulation of bile acid signal transduction causes neurological dysfunction in cirrhosis rats
《World Journal of Hepatology》2025年第3期140-151,共12页Chao Ren Li Cha Shu-Yue Huang Guo-Hui Bai Jin-Hui Li Xin Xiong Yu-Xing Feng Dui-Ping Feng Long Gao Jin-Yu Li 
Supported by the National Natural Science Foundation of China,No.82200650;the Key Research and Development Projects of Shanxi Province,No.202102130501014;the Natural Science Foundation of Shanxi Province,No.202203021211021,No.202203021212046,and No.20210302123258.
BACKGROUND The pathogenesis of hepatic encephalopathy(HE)remains unclear,and the classical theory of ammonia toxicity lacks sufficient justification.AIM To investigate the potential of bile acids as intervention targe...
关键词：Hepatic encephalopathy Total bile acid THIOACETAMIDE G protein-coupled bile acid receptor 1 Liver cirrhosis 
The Role of Glutathione S-Transferase in the Regulation of Plant Growth, and Responses to Environmental Stresses
《Phyton-International Journal of Experimental Botany》2025年第3期583-601,共19页Chen Lin Zidan Zhang Zhao Zhang Yuxiang Long Xuwen Shen Jinghao Zhang Youping Wang 
funded by National Natural Science Foundation of China(grant no.32301870 to Chen Lin);Natural Science Foundation of Jiangsu Province(grant no.BK20230568 to Chen Lin);the Jiangsu Provincial Agricultural Science and Technology Independent Innovation Fund(grant no.CX(24)3124 to Chen Lin);Outstanding Ph.D.Programin Yangzhou(grant no.YZLYJFJH2022YXBS147 to Chen Lin);the General Project of Basic Scientific Research to colleges and universities in Jiangsu Province(grant no.22KJB210019 toChen Lin);the Priority Academic Program Development of Jiangsu Higher Education Institutions is greatly acknowledged.
Glutathione S-transferases (GSTs) represent a large and diverse enzyme family ubiquitously distributed across the plant kingdom. These proteins catalyze the conjugation of glutathione (GSH) with electrophilic substrat...
关键词：Glutathione S-transferase biotic and abiotic stress plant growth and development signal transduction biological functions 
Fine control of growth and thermotolerance in the plant response to heat stress被引量：1
《Journal of Integrative Agriculture》2025年第2期409-428,共20页Yulong Zhao Song Liu Kaifeng Yang Xiuli Hu Haifang Jiang 
supported by the National Natural Science Foundation of China(32171945,32301760);the Program for Innovative Research Team(in Science and Technology)in University of Henan Province,China(22IRTSTHN023);the Scientific and Technological Research Project of Henan Province,China(242102111116);the National Science Foundation for Postdoctoral Scientists of China(2023M731003);the Postdoctoral Research Subsidize Fund of Henan Province,China(HN2022139)。
Global warming impacts plant growth and development,which in turn threatens food security.Plants can clearly respond to warm-temperature(such as by thermomorphogenesis)and high-temperature stresses.At the molecular le...
关键词：heat stress signal transduction tolerance mechanisms trade-off 
Effects of acupuncture on SATB1/p21 signaling pathway and SASPs in MPTP-induced Parkinson disease model mice
《Journal of Acupuncture and Tuina Science》2025年第1期1-11,共11页LI Guona ZHAO Chen WANG Zhaoqin HUA Xuegui WU Luyi ZHANG Xiyin SHEN Lin CHEN Ziyi HU Wenqing CHEN Yiyi CHENG Ling QIAO Yu 
国家中医药管理局高水平中医药重点学科建设项目,No.zyyzdxk-2023068;国家自然科学基金项目,No.82205260;上海市浦东新区卫计委名中医培养计划,No.PWRzm2020-12;浦东新区卫计委学科建设中医针灸重点专科,No.PWZzk2022-25.
Objective:To observe the effects of acupuncture on the motor function of Parkinson disease(PD)model mice and to investigate the neuroprotective effects of acupuncture on PD from the perspective of cellular senescence....
关键词：Acupuncture Therapy Point Baihui(GV20) Point Yanglingquan(GB34) Parkinson Disease Signal Transduction Cell Aging Mice 
Network pharmacology-based study on the mechanism of Tangfukang formula(糖复康方) against type 2 diabetes mellitus
《Journal of Traditional Chinese Medicine》2025年第1期76-88,共13页YAN Kai WANG Wei WANG Yan GAO Huijuan FENG Xingzhong 
Tsinghua Precision Medicine Foundation:Tangfukang Plays the Therapeutic Role in Type 2 Diabetes Patients with Qi and Yin Deficiency Syndrome by Regulating the Intestinal Flora Mediated Branched-chain Amino Acids-Phosphatidylinositide 3-Kinases-Protein Kinase B Signaling Pathway(grant number 10001020105);National Natural Science Foundation of China:Tangfukang Plays the Therapeutic Role in Type 2 Diabetes Mellitus by Regulating the Intestinal Flora Mediated Adiponectin-adenosine 5-Monophosphate-activated Protein Kinase-branched-chain Amino Acids Signaling Pathway(grant number 82104812)。
OBJECTIVE:To explore the mechanism of Tangfukang formula(糖复康方,TFK)in treating type 2 diabetes mellitus(T2DM).METHODS:We employed network pharmacology combined with experimental validation to explore the potential ...
关键词：network pharmacology diabetes mellitus type 2 AMP-activated protein kinase kinases signal transduction MECHANICS Tangfukang formula 
Blocking the PD-1 signal transduction by occupying the phosphorylated ITSM recognition site of SHP-2
《Science China(Life Sciences)》2025年第1期189-203,共15页Wenjie Li Wenyi Mei Hewei Jiang Jie Wang Xiaoli Li Lina Quan Yanyan Diao Yanni Ma Sisi Fan Zhuwei Xie Mengdie Gong Huan Zhu Dewen Bi Feng Zhang Lei Ma Jian Zhang Yufeng Gao Aris Paschalidis Honghuang Lin Fangfang Liu Kangdong Liu Mingliang Ye Zhenjiang Zhao Yajun Duan Zhuo Chen Yufang Xu Weilie Xiao Shengce Tao Lili Zhu Honglin Li 
supported in part by the National Natural Science Foundation of China (81825020, 82150208, 82260682);the National Key R&D Program of China (2022YFC3400501, 2022YFC3400504);the Shanghai Science and Technology Commission Biomedical Science and Technology Support Special Project (21S11907900, 20S11901000);Project of Yunnan Characteristic Plant Screening and R&D Service CXO Platform (2022YKZY001);sponsored by the National Program for Special Supports of Eminent Professionals;National Program for Support of Top-notch Young Professionals
Targeting the PD-1/PD-L1 axis with small-molecular inhibitors is a promising approach for immunotherapy.Here,we identify a natural pentacyclic triterpenoid,Pygenic Acid A(PA),as a PD-1 signaling inhibitor.PA exerts an...
关键词：pygenic acid A programmed death-1 immunoreceptor tyrosine-based switch motif SH2 domain-containing protein-tyrosine phosphatase-2 target identification site recognition 
Moxibustion inhibits the macrophage M1 polarization toll-like receptor 4/myeloid differentiation factor 88/nuclear factor kappa B signaling pathway by regulating T-cell immunoglobulin and mucin-containing protein-3 in rheumatoid arthritis
《Journal of Traditional Chinese Medicine》2024年第6期1227-1235,共9页LUO Kun ZHONG Yumei GUO Yanding ZHANG Linlin HU Danhui MA Wenbin YANG Xin ZHOU Haiyan 
the National Natural Science Foundation of China:Study on Immunoregulatory Mechanism of Moxibustion"Regulating Weiqi"to Regulate the Intrasynovial Environment Steady State in Rheumatoid Arthritis Model Rats based on the Skin-resident Memory T cells-Growth Arrest-specific 6/Mer Tyrosine Kinase (No. 82374587);the National Natural Science Foundation of China:Study on the Immune Mechanisms of Macrophage M1/M2 Polarization in the Treatment of Rheumatoid Arthritis by Moxibustion"Strengthening Body Resistance and Eliminating Evil"(No. 81973959);the National Key R&D Program of China:Research on the Functional Characteristics of"Special Effects"and"Common Effects"of Acupoints (No. 2019YFC1709001);Science and Technology Innovation Seedling Project of Sichuan Province:based on Macrophage M1 Polarization Signaling Pathway Toll-like receptor 4/Myeloid differentiation factor 88/Nuclear factor kappa B and its Regulatory Molecule T-cell Immunoglobulin and Mucin-containing Protein-3 Exploring the Effect Mechanism of Moxibustion on Experimental Rheumatoid Arthritis Model (No. 2022037)。
OBJECTIVE: To explore whether moxibustion exerts therapeutic effects on rheumatoid arthritis(RA) by regulating the expression of T-cell immunoglobulin and mucin-containing protein-3(TIM-3) and subsequently modulating ...
关键词：MOXIBUSTION ARTHRITIS RHEUMATOID TIM-3 macrophage polarization toll-like receptor 4 myeloid differentiation factor 88 nuclear factor kappa B signal transduction 
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