SMAD2

作品数:357被引量:1456H指数:16
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相关领域:医药卫生更多>>
相关作者:杨晓牛忠英张瑶胡雯辉于力更多>>
相关机构:华中科技大学复旦大学军事医学科学院中国医科大学更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划江苏省自然科学基金更多>>
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miR-503-3p promotes epithelialemesenchymal transition in breast cancer by directly targeting SMAD2 and E-cadherin被引量:15
《Journal of Genetics and Genomics》2017年第2期75-84,共10页Zitong Zhao Xinyi Fan Lanfang Jiang Zhongqiu Xu Liyan Xue Qimin Zhan Yongmei Song 
supported by funding from the National Key Basic Research Program of China(973 Program,No.2012CB967003);the National Natural Science Foundation of China(Nos.81472661,21335007,and 81402463);the National High Technology Research and Development Program of China(863 Program,No.2015AA020104)
Although progress in clinical and basic research has significantly increased our understanding of breast cancer, little is known about the molecular mechanism underlying breast cancer metastasis. Identification of eff...
关键词:Breast cancer miR-503-3p Plasma miRNA SMAD2 E-cadherin 
Enhanced Expression of miR-425 Promotes Esophageal Squamous Cell Carcinoma Tumorigenesis by Targeting SMAD2被引量:11
《Journal of Genetics and Genomics》2015年第11期601-611,共11页Lingyan Liu Zitong Zhao Wei Zhou Xinyi Fan Qimin Zhan Yongmei Song 
supported by the funding from the National High Technology Research and Development Program of China (863 Program) (Nos. 2012AA02A206 and 2011AA02A110);the National Key Basic Research Program of China (973 Program) (Nos. 2011CB910801 and 2011CB911004);the National Key Special Program on Infection diseases (No. 2013ZX10002009)
Esophageal squamous cell carcinoma (ESCC) is one of the most common and deadly cancers in the world, Currently, clinical therapy of ESCC remains limited and the five-year survival rate is poor. The function of miR-4...
关键词:Esophageal squamous cell carcinoma miR-425 Plasma miRNA SMAD2 
HSP70 decreases receptor-dependent phosphorylation of Smad2 and blocks TGF-β-induced epithelial-mesenchymal transition被引量:5
《Journal of Genetics and Genomics》2011年第3期111-116,共6页Yihao Li Xianjiang Kang Qiang Wang 
supported by grants from the National Natural Science Foundation of China(No.90919058);the National Basic Research Program of China(Nos. 2011 CB943904 and 2011 CB943800)
Smad2 and Smad3, the intracellular mediators of transforming growth factor β (TGF-β) signaling, are directly phosphorylated by the activated type I receptor kinase, and then shuttle from the cytoplasm into the nuc...
关键词:TGF-Β HSP70 SMAD2 EMT 
shRNAs介导的Smad2基因在小鼠成纤维细胞NIH/3T3中表达的沉默
《解剖学报》2008年第5期661-665,共5页郑嵘 熊琪 蒋思文 左波 李凤娥 徐德全 任竹青 熊远著 
国家重点基础研究发展计划(973)资助项目(2006CB102102)
目的通过构建5个shRNA表达质粒,对转化生长因子β/Smads信号通路中受体调节性Smads蛋白中的Smad2的表达进行抑制。方法针对鼠Smad2基因的mRNA序列,设计合成了5条shRNA-Smad2 DNA序列,分别插入至shRNA表达载体中,获得了5个shRNA-Smad2表...
关键词:RNA干扰 基因沉默 短发夹状RNA 转化生长因子β SMAD2 免疫印迹法 小鼠 
子宫颈上皮内瘤样病变和子宫颈癌组织中Smad2/3和HPV16 E7的表达及意义被引量:4
《癌症》2007年第9期967-971,共5页田媛 吴鹏 罗爱月 奚玲 周剑锋 马丁 
国家自然科学基金(No.30500596);国家重大基础研究项目(No.2002CB513107)~~
背景与目的:Smads蛋白是转化生长因子-β(transforming growth factor-β,TGF-β)超家族信号转导的下游信号蛋白,与多种肿瘤的发生密切相关;人乳头状瘤病毒(human papilloma virus,HPV)感染是宫颈癌的重要致癌因素,但目前对两者在宫颈...
关键词:宫颈肿瘤 宫颈上皮内瘤样病变 SMAD2 SMAD3 HPV16 E7 
Expression of Smad2 and Smad4 in rhesus monkey endometrium during the menstrual cycle and early pregnancy被引量:1
《Progress in Natural Science:Materials International》2003年第8期584-589,共6页LINHaiyan WANGHongmei LIQinglei WANGJuan ZHANGXuan LIUDonglin LIUHuitu ZHUCheng 
Supported by the Special Funds for Major State Basic Research Project (Grant No.G1999055903) and CAS Innovation Program (Grant No.KSCX3-IOZ-07)
Expression of Smad.2 and Smad4 mRNAs in the endometrium of rhesus monkey on Days 8, 20 and 28 of the normal menstrual cycle and on Days 12, 18 and 26 of early pregnancy was detected using in situ hybridization. The re...
关键词:SMAD rhesus monkey PREGNANCY menstrual cycle endometrium. 
增生瘢痕中转化生长因子基因的表达被引量:24
《中华外科杂志》2002年第1期17-19,共3页陈伟 付小兵 孙同柱 孙晓庆 赵志力 盛志勇 
国家重大基础研究规划资助项目 (G19990 5 42 0 4) ;国家杰出青年科学基金 ( 395 2 5 0 2 4);全军九五医学科研基金重点课题( 98Z0 90 )资助项目
目的 探讨转化生长因子 (TGF) β1和转录因子Smad 2 ,Smad 3三种基因影响增生性瘢痕形成和皮肤伤口无瘢痕愈合的调节机制。方法  3 2份被检测标本中包括增生性瘢痕 8份 ,其自体正常皮肤组织 8份 ,胎儿和成人皮肤组织各 8份。用逆转...
关键词:转化生长因子Β 增生瘢痕 转录因子 伤口愈合 TGF-Β1 SMAD2 SMAD3 
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