supported by the National Natural Science Foundation of China(Grant Nos.82372705 and 31870748);the Shanghai Oriental Elite Project(Grant No.2000152009);the National Key R&D Program of China(Grant No.2017YFE0196300);the Shanghai Natural Science Foundation(Grant No.22ZR1466100);the Fundamental Research Funds for the Central Universities(Grant No.22120230292);the China Postdoctoral Science Foundation(Grant Nos.2023M742651 and GZC20231946);the Shuguang Project of Shanghai Municipal Education Commission and Shanghai Education Development Foundation(Grant No.17SG19);the Outstanding Yong Medical Scholar of Shanghai Municipal Commission of Health and Family Planning(Grant No.2017YQ067);the Outstanding Yong Scholar Grant of Tongji University(Grant No.PA2019000239);the Startup Funding of Frontier Science Research Center for Stem Cells&Shanghai East Hospital of Tongji University(Grant No.DFRC2019003),China.
Topologically associating domain(TAD)reorganization commonly occurs in the cell nucleus and contributes to gene activation and inhibition through the separation or fusion of adjacent TADs.However,functional genes impa...
supported by the Beijing Nova Program of Science and Technology(No.20220484198 to HC);the National Natural Science Foundation of China(Nos.62173338,61873276 and 31900488 to HC,XB,and HL,respectively).
Background:The hierarchical three-dimensional(3D)architectures of chromatin play an important role in fundamental biological processes,such as cell differentiation,cellular senescence,and transcriptional regulation.Ab...