THERAPEUTICS

作品数：507被引量：1768H指数：18
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相关作者：陆世锋赫军王剑王琳蒋天安更多>>
相关机构：沈阳大陆激光技术有限公司中国科学院上海生命科学研究院北京工业大学广西中医药大学第一附属医院更多>>
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In vivo self-assembled small RNAs as a new generation of RNAi therapeutics被引量：14
《Cell Research》2021年第6期631-648,共18页Zheng Fu Xiang Zhang Xinyan Zhou Uzair Ur-Rehman Mengchao Yu Hongwei Liang Hongyuan Guo Xu Guo Yan Kong Yuanyuan Su Yangyang Ye Xiuting Hu Wei Cheng Jinrong Wu Yanbo Wang Yayun Gu Sheng-feng Lu Dianqing Wu Ke Zen Jing Li Chao Yan Chen-Yu Zhang Xi Chen 
supported by grants from the National Basic Research Program of China(973 Program)(2014CB542300);the National Natural Science Foundation of China(32022015,32001077,31871295 and 21877060);the Natural Science Foundation of Jiangsu Province(BE2016737);the Fundamental Research Funds for the Central Universities(020814380125,020814380130,020814380133 and 020814380146);supported by a research grant from the State Key Laboratory of Reproductive Medicine(SKLRM-K201801).
RNAi therapy has undergone two stages of development,direct injection of synthetic siRNAs and delivery with artificial vehicles or conjugated ligands;both have not solved the problem of efficient in vivo siRNA deliver...
关键词：VIVO LUNG gramme 
ICG@ZIF-8:One-step encapsulation of indocyanine green in ZIF-8 and use as a therapeutic nanoplatform被引量：6
《Chinese Chemical Letters》2018年第9期1421-1424,共4页Chao Yang Jing Xu Dandan Yang Xiaoxiao Wang Bin Liu Nongyue He Zhifei Wang 
financially supported by the State Key Basic Research Program of the PRC(No.2014CB744501);the NSF of China(No.81771976);Fundamental Research Funds for the Central Universities;the joint fund of Southeast University and Nanjing Medical University
How to fabricate zeolitic imidazole framework-8 （ZIF-8） based therapeutic nanoplatform will be of significance in biomedicine considering its good biocompatibility. Herein, we report a one-step encapsulation of indo...
关键词：ZIF Therapeutics nanoplatform Chemo-photothermal treatment Indocyanine Green ONE-STEP 
Effect of Ningmitai capsule plus sertraline on patients with premature ejaculation and enlarged seminal vesicles:A randomized clinical trial被引量：3
《Journal of Traditional Chinese Medicine》2018年第2期266-271,共6页Peng Longping Hong Zhiwei Shen Jiaming Hu Xuechun Shao Yong Jing Jun Lu Jinchun Yao Bing 
Supported by a Grant from the National Key Basic Research Program of China(No.2013CB945204);a Research and Development Project for Young Doctors in Reproductive Medicine from the Chinese Medical Association Specialized Fund for Clinical Medical Research(No.16020380654)
OBJECTIVE: To investigate the effects of Ningmitai capsule combined with sertraline on patients with premature ejaculation(PE) and an increased anterior-posterior diameter(APD) of the seminal vesicles(SVs).METHODS: Si...
关键词：Premature ejaculation Seminal vesi-cles THERAPEUTICS Ningmitai capsule Randomizedclinical trials 
Strategies for Antiviral Screening Targeting Early Steps of Virus Infection被引量：1
《Virologica Sinica》2010年第4期281-293,共13页Tao PENG 
National Basic Research Program (973) (2009CB522300,2010CB530100);Chinese Academy of Sciences (KSCX1-YW-10);Science and Technology Program of Guangzhou,China (2007Z1-E0111)
Viral infection begins with the entry of the virus into the host target cell and initiates replication. For this reason, the virus entry machinery is an excellent target for antiviral therapeutics. In general, a virus...
关键词：Virus Infection Antiviral therapeutics Virus life cycle Inhibitor screening 
Early metabolism evaluation making traditional Chinese medicine effective and safe therapeutics被引量：6
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2006年第2期99-106,共8页刘勇 杨凌 
ProjectsupportedbytheNationalBasicResearchProgram(973)ofChina(Nos.2003CCA03400and2003CB716005),andtheLeadingProgramoftheChineseAcademyofSciences(No.KGCXZ-SW-213-04),China
Increasing attention is being paid to the scientific evaluation of traditional Chinese medicine （TCM）. As many TCMs are capable of biotransformation in the gastrointestinal tract, attention to biotransforrnation of ...
关键词：Traditional Chinese medicine （TCM） METABOLISM Gastrointestinal biotransformation 
ANTITUMOR EFFECTS OF MONOCLONAL ANTIBODY FAB’FRAGMENT—CONTAINING IMMUNOCONJUGATES被引量：8
《Chinese Medical Sciences Journal》2002年第1期1-6,共6页LiuXiaoyun ZhenYongsu 
This work was supported by the grants from the National Key Research Project Funds，国家重点基础研究发展计划(973计划)
Objective.Using monoclonal antibody (mAb) Fab′ fragment to develop mAb immunoconjugates for cancer. Methods.Fab′ fragment of mAb 3A5 was prepared by digestion of the antibody with pepsin and then reduced by dithioth...
关键词：monoclonal antibody therapeutics Fab′ fragment IMMUNOCONJUGATES antineopla  stic agent 
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