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X40: 作品数：71被引量：6H指数：2; 导出分析报告; 相关领域：医药卫生自动化与计算机技术更多>>; 相关作者：张连山张宏恺王媛王军志杨雅岚更多>>; 相关机构：力帆实业(集团)股份有限公司信达生物制药(苏州)有限公司百济神州有限公司德克萨斯州立大学董事会更多>>; 相关期刊：更多>>; 相关基金：镇江市科技局社会发展基金福建省自然科学基金俄罗斯基础研究基金更多>>

The synergistic antitumor effect of Karanahan technology and in situ vaccination using anti-OX40 antibodies: 《Oncology Research》2025年第5期1229-1248,共20页VERA RUZANOVA ANASTASIA PROSKURINA GENRIKH RITTER EVGENIYA DOLGOVA SOFYA OSHIKHMINA SVETLANA KIRIKOVICH EVGENIY LEVITES YAROSLAV EFREMOV OLEG TARANOV ALEXANDR OSTANIN ELENA CHERNYKH NIKOLAY KOLCHANOV SERGEY BOGACHEV; supported by Inga N.Zaitseva;“Karanahan”LLC and the Ministry of Science and Higher Education of the Russian Federation via the Institute of Cytology and Genetics(State Budget Project No.FWNR-2022-0016).; Objectives:Currently,there exist two approaches to the treatment of malignant neoplasms:the Karanahan technology and in situ vaccination,which are based on chronometric delivery of therapeutic agents to the tumor depe...; 关键词：Karanahan technology OX40 Antitumor immunity Tumor-initiating stem cells Systemic inflammatory reaction

新型抗OX40抗体Ab18的Fc段改造与鉴定: 《国际生物制品学杂志》2024年第5期269-274,共6页王明辉梁红远张坤明瞿爱东陈哲文; 目的对抗肿瘤坏死因子受体超家族成员4(OX40)单克隆抗体Ab18进行结构优化和生物学活性初步鉴定。方法采用ELISA检测Ab18与不同物种OX40的种属交叉结合活性。用流式细胞术(flow cytometry, FCM)检测Ab18与HEK293-hOX40细胞的结合活性。...; 关键词：OX40 特应性皮炎抗体激动活性抗体依赖性细胞介导的细胞毒作用

工作辊锻件表面开裂分析: 《锻造与冲压》2024年第17期73-76,共4页张根红赵日红; 工作辊是轧机中的重要部件,在轧制过程中直接与坯料接触,工作时承受高温、高速、高载荷,工作环境恶劣,我公司生产的X40CrMoV51工作辊在调质热处理后发现表面有细小裂纹,为确定裂纹性质及产生原因对工作辊进行检验分析。; 关键词：工作辊调质热处理表面开裂细小裂纹高载荷 X40 轧制过程轧机

抗OX40/EGFR双特异性抗体的制备和活性鉴定: 《首都医科大学学报》2024年第2期296-301,共6页晋瑞娜边海波张晓敏杨帆王晚萍; 山西省自然科学基金面上项目(20210302124004);山西省卫健委项目(2022024)。; 目的构建同时靶向表皮生长因子受体(epidermal growth factor receptor,EGFR)和OX40的双特异性抗体,并在体外初步验证其对T细胞的特异性激活作用。方法构建抗OX40/EGFR双特异性抗体的真核表达载体,转染293F细胞进行表达和纯化。构建外...; 关键词：OX40 表皮生长因子受体双特异性抗体癌症 T细胞激活

Anti-OX40 Antibody Combined with HBc VLPs Delays Tumor Growth in a Mouse Colon Cancer Model: 《Biomedical and Environmental Sciences》2024年第2期187-195,共9页LIU Jia Jia SU Qiu Dong YI Yao SHEN Li Ping BI Sheng Li; supported by National Major Science and Technology Projects of China 2017ZX10105015-001-002。; Objective Combination immunotherapy strategies targeting OX40,a co-stimulatory molecule that can enhance antitumor immunity by modulating the proliferation,differentiation,and effector function of tumor-infiltrating T...; 关键词：Anti-OX40 antibody Hepatitis B core virus-like particles Tumor Combination therapy

BGB-A445,a novel non-ligand-blocking agonistic anti-OX40 antibody,exhibits superior immune activation and antitumor effects in preclinical models: 《Frontiers of Medicine》2023年第6期1170-1185,共16页Beibei Jiang Tong Zhang Minjuan Deng Wei Jin Yuan Hong Xiaotong Chen Xin Chen Jing Wang Hongjia Hou Yajuan Gao Wenfeng Gong Xing Wang Haiying Li Xiaosui Zhou Yingcai Feng Bo Zhang Bin Jiang Xueping Lu Lijie Zhang Yang Li Weiwei Song Hanzi Sun Zuobai Wang Xiaomin Song Zhirong Shen Xuesong Liu Kang Li Lai Wang Ye Liu; t OX40 is a costimulatory receptor that is expressed primarily on activated CD4+,CD8+,and regulatory T cells.The ligation of OX40 to its sole ligand OX40L potentiates T cell expansion,differentiation,and activation an...; 关键词：BGB-A445 OX40 agonistic antibody OX40L noncompetitive

Antitumor efficacy of multi-target in situ vaccinations with CpG oligodeoxynucleotides,anti-OX40,anti-PD1 antibodies,and aptamers: 《The Journal of Biomedical Research》2023年第3期194-212,共19页Anastasia S.Proskurina Vera S.Ruzanova Genrikh S.Ritter Yaroslav R.Efremov Zakhar S.Mustafin Sergey A.Lashin Ekaterina A.Burakova Alesya A.Fokina Timofei S.Zatsepin Dmitry A.Stetsenko Olga Y.Leplina Alexandr A.Ostanin Elena R.Chernykh Sergey S.Bogachev; supported by the Russian Ministry of Science and High Education via the Institute of Cytology and Genetics (State Budget Project No.FWNR-2022-0016);the Russian Foundation for Basic Research (Grant No.18-29-09045).; To overcome immune tolerance to cancer,the immune system needs to be exposed to a multi-target action intervention.Here,we investigated the activating effect of CpG oligodeoxynucleotides(ODNs),mesyl phosphoramidate Cp...; 关键词：IMMUNOGENICITY Krebs-2 carcinoma Lewis carcinoma Ehrlich carcinoma A20 B cell lymphoma mesyl phosphoramidate

硬核新旗舰手机中的SUV moto X40新机首发评测体验: 《微型计算机》2023年第1期52-57,共6页田东(文/图); 有人说它是最大黑马,也有人说它不负“王者归来”,过去一年,再焕活力的摩托罗拉成为了智能手机圈里无可争议的“卷王”。比如远有一年前moto X30首次将顶级旗舰的首发价打破3000元价位,近有不到6000元的moto razr 2022摘得折叠屏手机品...; 关键词：智能手机摩托罗拉移动平台新旗舰

实力霸屏,满帧战神荣耀X40 GT正式发布: 《数字家庭》2022年第11期14-15,共2页; 10月13日,荣耀举行新品发布会,正式推出了荣耀X40系列全新成员——荣耀X40 GT.荣耀X40 GT延续荣耀X40系列的“跃级”理念,不仅配备竞速战衣,还通过旗舰级骁龙888芯片、13层立体散热神装及GT级系统调优打造出战神性能铁三角,为消费者带...; 关键词：铁三角战神新品发布会旗舰级消费者

配齐阵线的“满帧”新作荣耀X40 GT: 《新潮电子》2022年第11期55-55,共1页; 作为荣耀X40系列新成员,荣耀X40 GT可以说是补齐了荣耀主攻游戏电竞市场的产品拼图。通过骁龙888旗舰芯片、13层立体散热系统等配置,该机型主打性能体验,针对重度游戏娱乐用户。这两年,荣耀进行了密集的产品矩阵调整。除了延续原先就已...; 关键词：高端市场游戏娱乐散热系统高性价比矩阵调整

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