We would like to thank Prof.Richard J.Youle(US National Institute of Neurological Disorders and Stroke)and Prof.Myung-Shik Lee(Yonsei University College of Medicine)for providing TFEB knockout HeLa cells.We thank Martha Dahlen for the English editing.This study was supported by the Hong Kong General Research Fund(GRF/HKBU12101417,GRF/HKBU12100618);the National Natural Science Foundation of China(81703487,and 81773926);Shenzhen Science and Technology Innovation Commission(JCYJ20180302174028790,JCYJ20180507184656626);the Hong Kong Health and Medical Research Fund(HMRF17182541,HMRF17182551);research funds from Hong Kong Baptist University(HKBU/RC-IRCs/17-18/03).
Transcriptional factor EB(TFEB),a master regulator of autophagy and lysosomal biogenesis,is generally regarded as a pro-survival factor.Here,we identify that besides its effect on autophagy induction,TFEB exerts a pro...
supported by the"Double First-Class"University Project(CPU2018GY10);the University Innovation Research and Training Program of China Pharmaceutical University(201610316123).
Oral administration of curcumin has been shown to inhibit pulmonary fibrosis(PF)despite its extremely low bioavailability.In this study,we investigated the mechanisms underlying the anti-PF effect of curcumin in focus...
Hunan university students’innovation and entrepreneurship training program(No.[2019]191-2440);Zhejiang provincial natural fund(No.GF18H140006)。
Objective:To explore the main physiological mechanism of 15d-PGJ2 promoting periodontal tissue regeneration in patients with jaw defects caused by periodontal disease.Methods:From February 2016 to July 2019,a controll...
This work was financially supported by the National Natural Science Foundation of China(grant 81703691);the Program for Jiangsu Province Innovative Research Team.The authors would like to thank Zhe Wang for the discussion of the manuscript.
Renal fibrosis is an inevitable outcome of all kinds of progressive chronic kidney disease(CKD).Recently,asiatic acid(AA),a triterpenoid compound from Chinese medicine Centella asiatica,has been found to attenuate ren...