This work was financially supported by the Ministry of Science and Technology of China(“973”Program 2013CB734003);the National Science Foundation of China(31670030).
Avermectins,a group of polyketide natural products,are widely used as anthelmintics in agriculture.Metabolic engineering and combinatorial biosynthesis were extensively employed to improve Avermectins production and c...
the National Program on Key Basic Research Project(973 program,2013CB734000 and 2012CB725203);the National Natural Science Foundation of China(31170095,31000057,and 31100075);the Ministry of Science and Technology of the People’s Republic of China(2011ZX11102-011-11 and 2013ZX10005004-005);China Ocean Mineral Resources R&D Association(DY125-15-T-07)。
The 2015 Nobel Prize in Physiology or Medicine has been awarded to avermectins and artemisinin,respectively.Avermectins produced by Streptomyces avermitilis are excellent anthelmintic and potential antibiotic agents.B...