Objective To assess the efficacy and safety of trimethoprim/sulfamethoxazole(TMP/SMZ)combined with caspofungin for the treatment of acquired immunodeficiency syndrome(AIDS)patients with moderate to severe pneumocystis...
Fundamental Research Funds for the Central Universities(20720200104)to LX;the Ministry of Science and Technology of China(2020YFA0112300 and 2020YFA0803600);the National Natural Science Foundation of China(82125028,U22A20320,91953114,31871319,81761128015,and 81861130370);the Natural Science Foundation of Fujian Province of China(2020J02004);the Fundamental Research Funds for the Central University(20720190145 and 20720220003)to WL;the China Postdoctoral Science Foundation(2022M720119)to ZZZ.Part of Fig.6 was drawnbyusingFigdraw.
Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)-induced cytokine storm is closely associated with coronavirus disease 2019(COVID-19)severity and lethality.However,drugs that are effective against inflammat...
The use of caspofungin in neonates is beyond the instructions. Therefore, a retrospective analysis was performed to investigate the hepatic safety of caspofungin during the treatment of fungal diseases in neonates. A ...
BACKGROUND Pneumocystis jirovecii pneumonia(PJP)is an infectious disease common in immunocompromised hosts.However,the currently,the clinical characteristics of non-HIV patients with PJP infection have not been fully ...
Caspofungin is an echinocandin antifungal agent licensed as a first-line therapy for invasive candidiasis in patients with moderate to severe illness or recent exposure to azoles. In this study we developed a whole-bo...
Background Nowadays,there are published trials in regards to the comparison of caspofungin with liposomal amphotericin B (L-AmB).However,these studies have a modest sample size and convey inconclusive results.The ai...
This work was supported by a grant from the National Natural Science Foundation of China (No. 30771939).
Trichosporon species now ranks as the second most common cause of disseminated yeast infections with a high mortality rate. Breakthrough trichosporonosis in patients receiving echinocandins therapy is being recognized...
To the Editor: Caspofungin is a new class of antifungal agents (echinocandins) for the treatment of fungal infections. Bynoncompetitive inhibition β-(1,3)-D-glucan synthase, it can destroy the glucan synthesis o...
PNEUMOCYSTIS pneumonia (PCP) is among the most common opportunistic infections in patients with acquired immune deficiency syndrome (AIDS).Although trimethoprim-sulfamethoxazole (TMP-SMX) is the first line therapy for...
Background During recent years, the incidence of serious infections caused by opportunistic fungi has increased dramatically due to alterations of the immune status of patients with hematological diseases, malignant t...