CASPOFUNGIN

作品数:18被引量:71H指数:5
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相关领域:医药卫生更多>>
相关作者:钱秀萍陈代杰王栋海戈升荣安富荣更多>>
相关机构:上海来益生物药物研究开发中心上海师范大学上海第二医科大学附属仁济医院北京大学第三医院更多>>
相关期刊:《Chinese Medical Sciences Journal》《中国抗生素杂志》《中国制药信息》《中华传染病杂志》更多>>
相关基金:国家自然科学基金更多>>
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Efficacy and safety of trimethoprim/sulfamethoxazole combined with caspofungin for the treatment of acquired immunodeficiency syndrome patients with moderate to severe pneumocystis pneumonia
《China Medical Abstracts(Internal Medicine)》2023年第3期147-148,共2页何小庆 
Objective To assess the efficacy and safety of trimethoprim/sulfamethoxazole(TMP/SMZ)combined with caspofungin for the treatment of acquired immunodeficiency syndrome(AIDS)patients with moderate to severe pneumocystis...
关键词:IMMUNODEFICIENCY PNEUMONIA TREATMENT 
A SARS-CoV-2-specific CAR-T-cell model identifies felodipine,fasudil,imatinib,and caspofungin as potential treatments for lethal COVID-19
《Cellular & Molecular Immunology》2023年第4期351-364,共14页in Xia Lun-zhi Yuan Ya-hong Hu Jun-yi Liu Guo-sheng Hu Ruo-yao Qi Tian-ying Zhang Hua-long Xiong Zao-zao Zheng Hong-wei Lin Jia-mo Zhang Chao Yu Ming Zhou Jian Ma Tong Cheng Ri-rong Chen Yi Guan Ning-shao Xia Wen Liu 
Fundamental Research Funds for the Central Universities(20720200104)to LX;the Ministry of Science and Technology of China(2020YFA0112300 and 2020YFA0803600);the National Natural Science Foundation of China(82125028,U22A20320,91953114,31871319,81761128015,and 81861130370);the Natural Science Foundation of Fujian Province of China(2020J02004);the Fundamental Research Funds for the Central University(20720190145 and 20720220003)to WL;the China Postdoctoral Science Foundation(2022M720119)to ZZZ.Part of Fig.6 was drawnbyusingFigdraw.
Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)-induced cytokine storm is closely associated with coronavirus disease 2019(COVID-19)severity and lethality.However,drugs that are effective against inflammat...
关键词:COVID-19 SARS-CoV-2 CAR-T anti-inflammation NF-kB pathway 
Hepatic safety of caspofungin during treatment of fungal diseases in neonates被引量:1
《Journal of Chinese Pharmaceutical Sciences》2022年第11期877-882,共6页Gaole Yuan Yingqiu Tu Weiwei Yan Fang Wang 
The use of caspofungin in neonates is beyond the instructions. Therefore, a retrospective analysis was performed to investigate the hepatic safety of caspofungin during the treatment of fungal diseases in neonates. A ...
关键词:CASPOFUNGIN Candida infection NEONATE Liver function 
Treatment of Pneumocystis jirovecii pneumonia in non-human immunodeficiency virus-infected patients using a combination of trimethoprim-sulfamethoxazole and caspofungin被引量:10
《World Journal of Clinical Cases》2022年第9期2743-2750,共8页Huan-Huan Wu Shuang-Yan Fang Yan-Xiao Chen Lan-Fang Feng 
BACKGROUND Pneumocystis jirovecii pneumonia(PJP)is an infectious disease common in immunocompromised hosts.However,the currently,the clinical characteristics of non-HIV patients with PJP infection have not been fully ...
关键词:Acquired immunodeficiency syndrome Non-human immunodeficiency virus-infected patients IMMUNOSUPPRESSION CASPOFUNGIN MORTALITY Pneumocystis jirovecii pneumonia 
Whole-body physiology-based pharmacokinetics of caspofungin for general patients, intensive care unit patients and hepatic insufficiency patients被引量:3
《Acta Pharmacologica Sinica》2018年第9期1533-1543,共11页Qian-ting YANG Ya-jing ZHAI Lu CHEN Tao ZHANG Yan YAN Ti MENG Lei-chao LIU Li-mei CHEN Xue WANG Ya- lin DONG 
Caspofungin is an echinocandin antifungal agent licensed as a first-line therapy for invasive candidiasis in patients with moderate to severe illness or recent exposure to azoles. In this study we developed a whole-bo...
关键词:CASPOFUNGIN antifungal agent whole-body physiology-based pharmacokinetics model intensive care unit hepaticinsuffciency cumulative fraction of response 
Caspofungin versus liposomal amphotericin B for treatment of invasive fungal infections or febrile neutropenia被引量:1
《Chinese Medical Journal》2014年第4期753-757,共5页Zhang Jinyu Gong Yizhen Wang Ke Kong Jinliang Chen Yiqiang 
Background Nowadays,there are published trials in regards to the comparison of caspofungin with liposomal amphotericin B (L-AmB).However,these studies have a modest sample size and convey inconclusive results.The ai...
关键词:CASPOFUNGIN liposomal amphotericin B META-ANALYSIS TREATMENT invasive fungal infections febrile neutropenia 
Breakthrough trichosporonosis in patients receiving echinocandins: case report and literature review被引量:1
《Chinese Medical Journal》2012年第14期2632-2635,共4页LIAO Yong Thomas Hartmann ZHENG Tao YANG Rong-ya AO Jun-hong WANG Wen-ling 
This work was supported by a grant from the National Natural Science Foundation of China (No. 30771939).
Trichosporon species now ranks as the second most common cause of disseminated yeast infections with a high mortality rate. Breakthrough trichosporonosis in patients receiving echinocandins therapy is being recognized...
关键词:trichosporonosis CASPOFUNGIN ECHINOCANDINS 
Hepatic safety of caspofungin during treatment of invasive fungal diseases in elderly patients被引量:6
《Chinese Medical Journal》2012年第12期2240-2240,共1页WANG Li-li ZHUGE Xin XIAO Guang-hui ZHANG Yun 
To the Editor: Caspofungin is a new class of antifungal agents (echinocandins) for the treatment of fungal infections. Bynoncompetitive inhibition β-(1,3)-D-glucan synthase, it can destroy the glucan synthesis o...
Lack of Response in Severe Pneumocystis Pneumonia to Combined Caspofungin and Clindamycin Treatment: a Case Report被引量:3
《Chinese Medical Sciences Journal》2011年第4期246-248,共3页Yao Zhang Hua Zhang Jun Xu Chan Wu Xiao-jun Ma 
PNEUMOCYSTIS pneumonia (PCP) is among the most common opportunistic infections in patients with acquired immune deficiency syndrome (AIDS).Although trimethoprim-sulfamethoxazole (TMP-SMX) is the first line therapy for...
关键词:pneumocystis pneumonia CASPOFUNGIN acquired immune deficiency syndrome TRIMETHOPRIM-SULFAMETHOXAZOLE 
In vitro susceptibility testing of Aspergillus spp. against voriconazole, itraconazole, posaconazole, amphotericin B and caspofungin被引量:11
《Chinese Medical Journal》2010年第19期2706-2709,共4页SHI Jun-yan XU Ying-chun SHI Yi LU Huo-xiang LIU Yong ZHAO Wang-sheng CHEN Dong-mei XI Li-yan ZHOU Xin WANG He GUO Li-na 
Background During recent years, the incidence of serious infections caused by opportunistic fungi has increased dramatically due to alterations of the immune status of patients with hematological diseases, malignant t...
关键词:aspergiUus antifungal agents drug resistance antifungal activity 
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