This work was supported by CAMS Innovation Fund for Medical Sciences (CIFMS) (2016-12M-1-001), the National Natural Science Foundation of China (31171299, 31271485, and 31301138), the National Basic Research Program of China (2012CB910703), and Tianjin Research Program of Application Foundation and Advanced Technology (12JC2DJC21400). C.Z. is supported by Program for New Century Excellent Talents in University in China (NCET-11-1066).
The chromokinesin Kif4A controls proper chromosome condensation, congression/alignment, and cytokinesis to ensure faithful genetic inheritance. Here, we report that Cdk phosphorylation of human Kif4A at T1161 licenses...