CENTRIN

作品数:12被引量:14H指数:2
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相关作者:陈娴马静韩代书薛社普唐永政更多>>
相关机构:北京师范大学中国医学科学院北京协和医学院华东师范大学北京协和医学院更多>>
相关期刊:《Journal of Rare Earths》《Science China(Life Sciences)》《生理科学进展》《Developmental and Reproductive Biology》更多>>
相关基金:国家自然科学基金国家重点基础研究发展计划山西省自然科学基金国家攀登计划更多>>
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KIFC1 overexpression promotes prostate cancer cell survival and proliferation in vitro by clustering of amplified centrosomes via interaction with Centrin 2
《BIOCELL》2021年第5期1369-1391,共23页ANZANA PARVIN BANG-HONG WEI SHUANG-LI HAO WAN-XI YANG FU-QING TAN 
Natural Science Foundation of Zhejiang Province,China(No.LY20H040010).
Mitotic kinesin KIFC1 plays critical roles in mitosis by regulating the spindle length,pole formation,and known for clustering extra centrosomes in cancer cells.Centrosome clustering is associated with the survival of...
关键词:KIFC1 Centrosome clustering Centrosome amplification Prostate cancer 
Effect of Tb(Ⅲ) on the unfolding of ciliate Euplotes octocarinatus centrin induced by guanidine hydrochloride
《Journal of Rare Earths》2018年第2期203-208,共6页Enxian Shi Wenlong Zhang Binsheng Yang 
Project supported by the National Natural Science Foundation of China(21571117);the PhD Programs Foundation of the Ministry of Education of China(20131401110011)
To understand the unfolding of ciliate Euplotes octocarinatus centrin(EoCen), the glycine positioned at 115, the sixth residue of the loop of the protein's third EF-hand, was mutated into tryptophan(Trp).Intrinsi...
关键词:Euplotes octocarinatus centrin Tb(Ⅲ) Unfolding Structure element Stability Rare earths 
Metal ion-binding properties of wild-type and mutant D37K of ciliate Euplotes octocarinatus centrin
《Chinese Science Bulletin》2010年第27期3118-3122,共5页LIU Wen DUAN Lian ZHAO YaQin LIANG AiHua YANG BinSheng 
supported by the National Natural Science Foundation of China(20771068,20901048);the Ph.D Programs Foundation of Ministry of Education of the People’s Republic of China(20091401110007);the Natural Science Foundation of Shanxi Province(2007011024)
Ciliate Euplotes octocarinatus centrin (EoCen) is an EF-hand calcium-binding protein closely related to the prototypical calcium sensor protein calmodulin.The first amino acid of the Ca2+-binding loops found in the EF...
关键词:CENTRIN 金属离子 突变型 纤毛虫 结合特性 游仆虫 野生型 钙结合蛋白 
Role of Asp37 in metal-binding and conformational change of ciliate Euplotes octocarinatus centrin被引量:1
《Health》2010年第3期262-267,共6页Wen Liu Lian Duan Bing Zhao Ya-Qin Zhao Ai-Hua Liang Bin-Sheng Yang 
Centrin is a member of the EF-hand super family that plays critical role in the centrosome duplication and separation. To investigate the role of Asp37 in the process of metal-binding and conformational change of cili...
关键词:CENTRIN Aspartic ACID TB3+ TNS 
Binding of Euplotes octocarinatus centrin with target peptide melittin被引量:2
《Chinese Science Bulletin》2007年第23期3216-3220,共5页ZHAO YaQin FENG JiuYing LIANG AiHua YANG BinSheng 
Supported by the National Natural Science Foundation of China (Grant Nos. 20371031 and 20771068);the Natural Science Foundation of Shanxi Province (Grant No. 2007011024) ;Young Science Foundation of Shanxi University
Interactions between model target peptide melittin (ME) and Euplotes octocarinatus centrin (EoCen) were investigated by fluorescence spectra, circular dichroism (CD) spectra and native polyacrylamide gel electrophores...
关键词:蜂毒肽 光谱 缩氨酸 生物学 
中心体蛋白centrin研究进展被引量:3
《生理科学进展》2004年第3期240-242,共3页陈娴 唐永政 王永潮 
国家重点基础研究发展计划项目 (G19990 5 390 1)资助课题
Centrin是普遍存在于中心体上的蛋白成分 ,具有钙离子结合能力。Centrin家族包含多种同源蛋白 ,这些蛋白在结构上高度保守。研究表明centrin可能与细胞的分化 ,纤毛的生成定向和切断 ,精子尾部的生成 ,中心体复制及其结构维持有密切关...
关键词:中心体蛋白 CENTRIN 中心体 纤毛 细胞周期 癌变 
The cloning and expression characterization of the centrosome protein genes family (centrin genes) in rat testis被引量:1
《Science China(Life Sciences)》2002年第6期655-662,共8页孙晓冬 俞作仁 薛社普 葛晔华 李赛 韩代书 马静 王永潮 
This work was supported by the Special Funds for Major State Basic Research Project (Grant No. G1999055901)
Centrins are members of the centrosome protein family, which is highly conserved during revolution. The homologous genes of centrin in many organisms had been cloned, but the sequences of the rat centrin genes were no...
关键词:centrin  centrosome  spermatogenesis. 
Abnormal expression of cen-trosome protein (centrin) in spermatozoa of male human infertility被引量:1
《Chinese Science Bulletin》2002年第10期822-823,881,共3页SUN Xiaodong MA Jing GE Yehua LI Sai YU Zuoren XUE Shepu HAN Daishu 
This work was supported by the National "973" Program of China (Grant No. G19990559-01).
To study the relations between male infertility and centrosome protein (centrin) and the functions of centrin in spermatogenesis, the matured spermatozoa of 10 normal male people and 18 male infertility patients were ...
关键词:CENTRIN CENTROSOME MALE INFERTILITY spermatozoa. 
中心体蛋白Centrin在不育症病人精子中的异常表达被引量:1
《科学通报》2002年第2期139-140,共2页孙晓冬 马静 葛晔华 李赛 俞作仁 薛社普 韩代书 
本工作为国家重点基础研究发展规划资助项目(批准号:G19990559(01))
为研究中心体蛋白Centrin与男性不育的关系,从而深入理解Centrin在精子发生过程中的功能,用抗Centrin多克隆抗体对10例正常人及18例男性不育症病人的成熟精子进行了免疫荧光染色.结果发现,在正常男性成熟精子中有两个明显的点状荧光阳...
关键词:CENTRIN 男性不育症 精子 中心体蛋白 异常表达 
中心体蛋白Centrin家族在大鼠精子发生过程中的表达
《Developmental and Reproductive Biology》2001年第B10期25-25,共1页孙晓冬 俞作仁 李赛 马静 葛晔华 薛社普 韩代书 
关键词:中心体蛋白 CENTRIN 大鼠 精子发生 表达 
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