Supported by the“Climbing Program”Construction Project“High Peak Project”Department of Major Infectious Disease Prevention and Control.
BACKGROUND Hepatitis B-associated cirrhosis is an important disease burden in China.However,there is a lack of effective predictors in clinical practice to drive delivery and enable early treatment to delay disease pr...
BACKGROUND Splenectomy is an effective yet invasive intervention for alleviating portal pressure in patients with hepatitis cirrhosis.However,the current prognostic indicators for predicting long-term overall survival...
The treatment of hepatitis C has undergone a significant boom since the advent of direct acting antivirals (DAA). Indeed, the interferon-ribavirin combination that has been used to treat hepatitis C has a virological ...
This work was funded by the Health Commission of Nanjing City(ZKX20021);Science and Technology Department of Jiangsu Province(BK20221169);Jiangsu Province Center for Innovation in Obstetrics and Gynecology(CXZX202229),China.
Chronic hepatitis B virus(HBV)infection,referred to the presence of hepatitis B surface antigen(HBsAg)over 6 months,is a serious health issue because of its severe sequelae such as cirrhosis and hepatocellular carcino...
T.G.C.is supported by the American Association for the Study of Liver Diseases(AASLD)Clinical,Translational and Outcomes Research Award(CTORA)and National Institute on Alcohol Abuse and Alcoholism(NIAAA)K23AA031310 grant;Research reported in this publication was supported by the NIAAA of the National Institutes of Health(NIH)under Award Number K23AA031310;The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.M.C.M.is supported by a grant from the National Institute on Alcohol Abuse and Alcoholism U01 AA026975;consults for GlaxoSmithKline,Amygdala NeProdigy,HepaTX,and Parvus;T.A.K.is supported by U01 AA026975 and has a research relationship with GSK and consults for Alexion.
Alcohol-associated liver disease(ALD)is a significant global health challenge,encompassing a spectrum from steatotic liver disease to cirrhosis and alcohol-associated hepatitis,and contributed to 25%of global cirrhosi...
Alcohol-related liver disease(ALD)encompasses a spectrum of diseases caused by excessive alcohol consumption.ALD includes hepatic steatosis,steatohepatitis,variable degrees of fibrosis,cirrhosis,and alcohol-associated...
BACKGROUND Liver disease incidence and hence demand on hepatology services is increasing.AIM To describe trends in incidence and natural history of liver diseases in Wales to inform effective provision of hepatology s...
Fibrolamellar carcinoma(FLC)is a rare variant of hepatocellular carcinoma(HCC),comprising 1%–9%of all HCCs.FLC is a poorly understood malignancy,which seems to be more prevalent in young patients with no underlying l...
Supported by the Nurturing Clinician Scientist Scheme(NCCS)award by SingHealth Duke-NUS Academic Medical Centre and National Medical Research Council Singapore.
BACKGROUND Hepatitis C virus(HCV)is a leading cause of liver cirrhosis and hepatocellular carcinoma globally.Sofosbuvir/velpatasvir(SOF/VEL)is an effective pangenotypic direct-acting antiviral combination for treatmen...
supported by the Scholarly Projects Program at Columbia University Vagelos College of Physicians and Surgeons,which had no role in the design or execution of this study.
Background and Aims:Vibration-controlled transient elastography(VCTE)is a noninvasive tool that uses liver stiffness measurement(LSM)to assess fibrosis.Since real-life data during everyday clinical practice in the USA...